PSD8A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD8A_ARATH
• UniProt AC: Q9SGW3
• Protein Name: 26S proteasome non-ATPase regulatory subunit 8 homolog A
• Gene Name: RPN12A {ECO:0000303|PubMed:14623884}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 267
• Protein Description: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. May help to control the degradation of one or more factors that repress cytokinin signaling. Plays an important role for balancing cell expansion with cell proliferation rates during shoot development..
• Protein Sequence: MDPQLTEVSQQFERFKAAFARKDYNTCSDLLSQLKVLLTKFTSLPPLFENSPNAAKELTIARDIYEHAVVLSVKTEDQDAFERDFFQLKPYYVDARNRIPQSPQENLILGLNLLRLLVQNRIAEFHTELELLSSATLEDPCIKHAVELEQSFMEGAYNRVLSARQTAPDATYVYFMDLLAKTIRDEIAGCSEKAYDYVSISDARQMLLFSSDQELLTYVTDEHPEWEVKEGFVVFQKAKETAPCKEIPSLQLINQTLSYARELERIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPQLTEV -------CCHHHHHH		20516081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PUB22	Q9SVC6	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	PUB23	Q84TG3	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD8A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD8A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUB23_ARATH	PUB23	physical	18664614
PUB22_ARATH	PUB22	physical	18664614

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.