CKB12_ARATH - dbPTM
CKB12_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CKB12_ARATH
UniProt AC Q2V419
Protein Name Cyclin-dependent kinase B1-2
Gene Name CDKB1-2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 311
Subcellular Localization
Protein Description Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. [PubMed: 20675570 In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage]
Protein Sequence MEKYEKLEKVGEGTYGKVYKAMEKTTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSQSIYIVRLLCVEHVIQSKDSTVSHSPKSNLYLVFEYLDTDLKKFIDSHRKGSNPRPLEASLVQRFMFQLFKGVAHCHSHGVLHRDLKPQNLLLDKDKGILKIADLGLSRAFTVPLKAYTHEIVTLWYRAPEVLLGSTHYSTAVDIWSVGCIFAEMIRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVMALRDWHVYPKWEPQDLSRAVPSLSPEGIDLLTQMLKYNPAERISAKAALDHPYFDSLDKSQF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationEKVGEGTYGKVYKAM
HCCCCCCHHHHHHHH
26.30-
53PhosphorylationPTALREISLLQMLSQ
HHHHHHHHHHHHHHC
20.4824894044
63PhosphorylationQMLSQSIYIVRLLCV
HHHHCHHHHHHHHHH
9.9024894044
178PhosphorylationTVPLKAYTHEIVTLW
CCCCHHHCCCEEEHE
20.21-
241PhosphorylationFRLLGTPTEQQWPGV
HHHHCCCCHHCCCCE
46.3824243849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CKB12_ARATH !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CKB12_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CKB12_ARATH !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CKS1_ARATHCKS1physical
20407024
CKB12_ARATHCDKB1;2physical
20407024
CKB21_ARATHCDKB2;1physical
20407024
CDKD2_ARATHCAK4physical
20407024
CDKD3_ARATHCDKD1;3physical
20407024
CDKE1_ARATHCDKE;1physical
20407024
CDKF1_ARATHCAK1ATphysical
20407024
CKS2_ARATHCKS2physical
20407024
CCA21_ARATHCYCA2;1physical
20407024
CCA22_ARATHCYC3Bphysical
20407024
CCA23_ARATHCYCA2;3physical
20407024
CCA24_ARATHCYCA2;4physical
20407024
CCA31_ARATHCYCA3;1physical
20407024
CCA34_ARATHCYCA3;4physical
20407024
CCB11_ARATHCYCB1;1physical
20407024
CCB12_ARATHCYC1BATphysical
20407024
CCB23_ARATHCYCB2;3physical
20407024
CCB31_ARATHCYCB3;1physical
20407024
CCD41_ARATHCYCD4;1physical
20407024
CCD42_ARATHCYCD4;2physical
20407024
CCD51_ARATHCYCD5;1physical
20407024
CCD61_ARATHCYCD6;1physical
20407024
CCH11_ARATHCYCH;1physical
20407024
E2FA_ARATHE2F3physical
20407024
KRP1_ARATHICK1physical
20407024
KRP2_ARATHKRP2physical
20407024
KRP3_ARATHICK6physical
20407024
KRP4_ARATHKRP4physical
20407024
KRP5_ARATHICK3physical
20407024
KRP6_ARATHKRP6physical
20407024
KRP7_ARATHICK5physical
20407024
CKS2_ARATHCKS2physical
20706207
EF115_ARATHAT5G07310physical
20706207
AB2E_ARATHRLI2physical
20706207
CKS1_ARATHCKS1physical
20706207
RH9_ARATHPMH1physical
20706207
LRP1A_ARATHAT5G21160physical
20706207

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CKB12_ARATH

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Related Literatures of Post-Translational Modification

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