LRP1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRP1A_ARATH
• UniProt AC: Q940X9
• Protein Name: La-related protein 1A
• Gene Name: LARP1A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 826
• Subcellular Localization: Cytoplasm, P-body . Cytoplasm, cytosol . Translocates from cytosol to P-bodies upon heat stress.
• Protein Description: Required for acclimation and survival during thermal stress. Heat-specific cofactor of XRN4 required for its targeting to polysomes and subsequent rapid degradation of seedling transcriptome during the early steps of the heat stress response..
• Protein Sequence: MMAETEGSVADDRELITREGGIGTKSPWKTTTSPVETIDAPVMGAHSWPALADAAQQPRPKNPPAPAPAPPSKNIPTSIPIPTPAVTGQAKSKGGGKANPGHKNPSGRHSKPGPRSNQNGPPPPPYLVHAVPYHPPPFPPMVPLPHAAGPDFPYAPYPPYPVPVPPVTESGNEKQVQASPLPPVLPAPQGDPGKPWPHQRGFDPRNMPQGAGPRNFGRPPFMGPAPGFLVGPGPGFPGPVYYLPGPPPGAIRGPYPPRFAPYPVNQGPPILSPEKLDLRDRVLKQVEYYFSDENLENDHYLISLMDEEGWVPTKIIAGFKRVKAMTMDVDFIVYALGFSNSVEVQGDQIRKRDKWSDWIPASKKSTSAETIGDGDKDSPKSITSGDNFGNPSKGSSKPTVSDFSSEGAQSSRTNNYKSGNLKSSADEKRNVEDLSNDFSNTFLLDEELDLEHRSPRKSGLSMSKSIEYEDDDMAVDDQDIQKLVIVTQNSGKSDGAGIGGTEAKNIPKELASTINDGLYYFEQELKKKRSGRRKNNSHLDTKDGKIKSGEGLNTKLGENSAANDGGEEHGIITSRRKQNKGTHKHHTAHARRFFSSNIRNNGNISESPPSSSIGFFFGSTPPDSHGPRLSKLSSSPQCTLSGSSPPVGSLPKSFPPFQHPSHQLLEENGFKQEKYLKYRKRCLNERKKLGSGCSEEMNHLYRFWSYFLRDTFVLSMYDDFQKFALEDAAGNYDYGLECLFRFYSYGLEKHFDEDLYKDFEKLSLDFYHKGNLYGLEKYWAFHHYRGKEEPITKHPELEKLLKEEFRSIDDFRAKETITNQKENKSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMAETEGS -------CCCCCCCC		22223895
5	Phosphorylation	---MMAETEGSVADD ---CCCCCCCCCCCH		25561503
8	Phosphorylation	MMAETEGSVADDREL CCCCCCCCCCCHHHH		25561503
365	Phosphorylation	WIPASKKSTSAETIG CCCCCCCCCCCEECC		23776212
366	Phosphorylation	IPASKKSTSAETIGD CCCCCCCCCCEECCC		23776212
367	Phosphorylation	PASKKSTSAETIGDG CCCCCCCCCEECCCC		23776212
370	Phosphorylation	KKSTSAETIGDGDKD CCCCCCEECCCCCCC		23776212
378	Phosphorylation	IGDGDKDSPKSITSG CCCCCCCCCCCCCCC		30291188
381	Phosphorylation	GDKDSPKSITSGDNF CCCCCCCCCCCCCCC		19880383
383	Phosphorylation	KDSPKSITSGDNFGN CCCCCCCCCCCCCCC		23776212
384	Phosphorylation	DSPKSITSGDNFGNP CCCCCCCCCCCCCCC		23776212
392	Phosphorylation	GDNFGNPSKGSSKPT CCCCCCCCCCCCCCC		23776212
395	Phosphorylation	FGNPSKGSSKPTVSD CCCCCCCCCCCCHHH		25561503
396	Phosphorylation	GNPSKGSSKPTVSDF CCCCCCCCCCCHHHC		25561503
404	Phosphorylation	KPTVSDFSSEGAQSS CCCHHHCCCCCCCCC		25561503
405	Phosphorylation	PTVSDFSSEGAQSSR CCHHHCCCCCCCCCC		25561503
410	Phosphorylation	FSSEGAQSSRTNNYK CCCCCCCCCCCCCCC		25561503
411	Phosphorylation	SSEGAQSSRTNNYKS CCCCCCCCCCCCCCC		25561503
435	Phosphorylation	KRNVEDLSNDFSNTF HCCHHHHHHHCCCCC		23776212
439	Phosphorylation	EDLSNDFSNTFLLDE HHHHHHCCCCCCCCC		23776212
441	Phosphorylation	LSNDFSNTFLLDEEL HHHHCCCCCCCCCHH		23776212
454	Phosphorylation	ELDLEHRSPRKSGLS HHCCCCCCCCCCCCC		30291188
458	Phosphorylation	EHRSPRKSGLSMSKS CCCCCCCCCCCCCCC		25561503
461	Phosphorylation	SPRKSGLSMSKSIEY CCCCCCCCCCCCEEE		25561503
463	Phosphorylation	RKSGLSMSKSIEYED CCCCCCCCCCEEECC		25561503
465	Phosphorylation	SGLSMSKSIEYEDDD CCCCCCCCEEECCCC		19880383
468	Phosphorylation	SMSKSIEYEDDDMAV CCCCCEEECCCCCCC		23776212
487	Phosphorylation	IQKLVIVTQNSGKSD HCEEEEEECCCCCCC		19880383
490	Phosphorylation	LVIVTQNSGKSDGAG EEEEECCCCCCCCCC		19880383
493	Phosphorylation	VTQNSGKSDGAGIGG EECCCCCCCCCCCCH		19880383
548	Phosphorylation	TKDGKIKSGEGLNTK CCCCCEECCCCCCCC		25561503
560	Phosphorylation	NTKLGENSAANDGGE CCCCCCCCCCCCCCC		30407730
605	Phosphorylation	IRNNGNISESPPSSS CCCCCCCCCCCCCCC		23776212
607	Phosphorylation	NNGNISESPPSSSIG CCCCCCCCCCCCCEE		23776212
610	Phosphorylation	NISESPPSSSIGFFF CCCCCCCCCCEEEEC		23776212
611	Phosphorylation	ISESPPSSSIGFFFG CCCCCCCCCEEEECC		23776212
612	Phosphorylation	SESPPSSSIGFFFGS CCCCCCCCEEEECCC		23776212
619	Phosphorylation	SIGFFFGSTPPDSHG CEEEECCCCCCCCCC		23776212
620	Phosphorylation	IGFFFGSTPPDSHGP EEEECCCCCCCCCCC		23776212
624	Phosphorylation	FGSTPPDSHGPRLSK CCCCCCCCCCCCHHH		23776212
633	Phosphorylation	GPRLSKLSSSPQCTL CCCHHHCCCCCCCCC		23776212
634	Phosphorylation	PRLSKLSSSPQCTLS CCHHHCCCCCCCCCC		23776212
635	Phosphorylation	RLSKLSSSPQCTLSG CHHHCCCCCCCCCCC		23776212
639	Phosphorylation	LSSSPQCTLSGSSPP CCCCCCCCCCCCCCC		23776212
641	Phosphorylation	SSPQCTLSGSSPPVG CCCCCCCCCCCCCCC		23776212
643	Phosphorylation	PQCTLSGSSPPVGSL CCCCCCCCCCCCCCC		23776212
644	Phosphorylation	QCTLSGSSPPVGSLP CCCCCCCCCCCCCCC		30291188
649	Phosphorylation	GSSPPVGSLPKSFPP CCCCCCCCCCCCCCC		30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRP1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRP1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRP1A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of LRP1A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.