dbPTM

CPNA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CPNA1_ARATH
UniProt AC	P21238
Protein Name	Chaperonin 60 subunit alpha 1, chloroplastic
Gene Name	CPN60A1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	586
Subcellular Localization	Plastid, chloroplast.
Protein Description	Binds RuBisCO small and large subunits and is implicated in the assembly of the enzyme oligomer. Involved in protein assisted folding. Required for proper chloroplast development..
Protein Sequence	MASANALSSASVLCSSRQSKLGGGNQQQGQRVSYNKRTIRRFSVRANVKEIAFDQHSRAALQAGIDKLADCVGLTLGPRGRNVVLDEFGSPKVVNDGVTIARAIELPNAMENAGAALIREVASKTNDSAGDGTTTASILAREIIKHGLLSVTSGANPVSLKRGIDKTVQGLIEELQKKARPVKGRDDIRAVASISAGNDDLIGSMIADAIDKVGPDGVLSIESSSSFETTVEVEEGMEIDRGYISPQFVTNPEKLLAEFENARVLITDQKITAIKDIIPILEKTTQLRAPLLIIAEDVTGEALATLVVNKLRGVLNVVAVKAPGFGERRKAMLQDIAILTGAEYLAMDMSLLVENATIDQLGIARKVTISKDSTTLIADAASKDELQARIAQLKKELFETDSVYDSEKLAERIAKLSGGVAVIKVGAATETELEDRKLRIEDAKNATFAAIEEGIVPGGGAALVHLSTVIPAIKETFEDADERLGADIVQKALLSPAALIAQNAGVEGEVVVEKIMFSDWENGYNAMTDTYENLFEAGVIDPAKVTRCALQNAASVAGMVLTTQAIVVDKPKPKAPAAAAPEGLMV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	ANALSSASVLCSSRQ CHHHHHHHHHHCCCC	19.98	29797451
75	Phosphorylation	LADCVGLTLGPRGRN HHHHHCCCCCCCCCC	24.60	19880383
90	Phosphorylation	VVLDEFGSPKVVNDG EEECCCCCCCEECCC	27.20	30291188
123	Phosphorylation	ALIREVASKTNDSAG HHHHHHHHHCCCCCC	45.23	19880383
125	Phosphorylation	IREVASKTNDSAGDG HHHHHHHCCCCCCCC	41.59	19880383
128	Phosphorylation	VASKTNDSAGDGTTT HHHHCCCCCCCCHHH	35.90	29797451
150	Phosphorylation	IIKHGLLSVTSGANP HHHCCCCEECCCCCC	28.52	22092075
447	Phosphorylation	IEDAKNATFAAIEEG HHHHHHCCEEEECCC	24.17	29654922
468	Phosphorylation	AALVHLSTVIPAIKE CHHHCHHHHHHHHHH	28.90	29654922
528	Phosphorylation	ENGYNAMTDTYENLF CCCCCCCHHHHHHHH	23.84	29797451
585	Sulfoxidation	AAAPEGLMV------ CCCCCCCCC------	5.03	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CPNA1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CPNA1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CPNA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CPNB1_ARATH	CPN60B	physical	25775508

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CPNA1_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	19376835 [Abstract]
"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana."; Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.; J. Proteomics 72:439-451(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	19245862 [Abstract]