PSD1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD1A_ARATH
• UniProt AC: O48844
• Protein Name: 26S proteasome non-ATPase regulatory subunit 1 homolog A
• Gene Name: RPN2A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1004
• Protein Description: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins..
• Protein Sequence: MATPMVSSAGGLLAMLNEPHPVLKLHALSNLNNLVDQFWPEISTSVPIIESLYEDEEFDLHQRQLAALLVSKVFYYLGELNDSLSYALGAGPLFDVSEDSDYVHTLLAKAIDEYASLRSKAVESNEMVDIDPRLEAIVERMLGKCISDGKYQQAMGIAIECRRLDKLEEAIIKSDNVQGTLSYCINVSHSFVNRREYRHEVLSLLVKVYQKLPSPDYLSICQCLMFLDEPQGVASILEKLLRSENKDDALLALQIAFDLVENEHQAFLLSVRDRLPAPKTRAVEATQAVETTIAPNENPSGDVQMADETPAQTIVHETDPVDATYAERLTKIKGILSGETSIQLTLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYANAIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQGGAGGGGSPYSEGGALYALGLIHANHGEGIKQFLRDSLRSTNVEVIQHGACLGLGLSALGTADEEIYDDVKSVLYTDSAVAGEAAGISMGLLLVGTATEKASEMLAYAHETQHEKIIRGLALGIALTVYGREEGADTLIEQMTRDQDPIIRYGGMYALALAYSGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSDPEQTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTSDVVDFVRQGALIAMAMVMVQISEASDSRVGVFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIRLLSKTKHDKVTAVIGLAVFSQFWYWYPLIYFISLAFSPTAFIGLNYDLKVPKFEFMSHAKPSLFEYPKPTTVPTANTAVKLPTAVLSTSVKAKARAKKEAEQKAIAEKTSGPEKPVNESGSGKGKASTEKEGDSMQVDSPAAVEKKAPEPEPAFEILVNPARVVPAQEKYIKLLDDSRYVPVKLAPSGFVLLKDLREHEPEVLSLTDAPTSTASPATGTAAAAQGTPASAMAVDDEPQPPQAFEYAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATPMVSSA ------CCCCCCCCH		22223895
127	Sulfoxidation	KAVESNEMVDIDPRL HCCCCCCCCCCCHHH		23289948
166	Ubiquitination	IECRRLDKLEEAIIK EEEECHHHHHHHHHH		20516081
430	Phosphorylation	GHLQQGRSLMAPYLP CCHHCCCCCCCCCCC		23776212
435	Phosphorylation	GRSLMAPYLPQGGAG CCCCCCCCCCCCCCC		23776212
446	Phosphorylation	GGAGGGGSPYSEGGA CCCCCCCCCCCHHHH		23776212
448	Phosphorylation	AGGGGSPYSEGGALY CCCCCCCCCHHHHCH		23776212
449	Phosphorylation	GGGGSPYSEGGALYA CCCCCCCCHHHHCHH		23776212
455	Phosphorylation	YSEGGALYALGLIHA CCHHHHCHHEEEEEC		23776212
844	Phosphorylation	KLPTAVLSTSVKAKA CCCHHHHCHHHHHHH		22631563
845	Phosphorylation	LPTAVLSTSVKAKAR CCHHHHCHHHHHHHH		22631563
846	Phosphorylation	PTAVLSTSVKAKARA CHHHHCHHHHHHHHH		22631563
866	Phosphorylation	QKAIAEKTSGPEKPV HHHHHHHCCCCCCCC		23776212
867	Phosphorylation	KAIAEKTSGPEKPVN HHHHHHCCCCCCCCC		23776212
876	Phosphorylation	PEKPVNESGSGKGKA CCCCCCCCCCCCCCC		23776212
878	Phosphorylation	KPVNESGSGKGKAST CCCCCCCCCCCCCCC		23776212
884	Phosphorylation	GSGKGKASTEKEGDS CCCCCCCCCCCCCCC		19880383
885	Phosphorylation	SGKGKASTEKEGDSM CCCCCCCCCCCCCCC		23776212
891	Phosphorylation	STEKEGDSMQVDSPA CCCCCCCCCCCCCHH		23776212
896	Phosphorylation	GDSMQVDSPAAVEKK CCCCCCCCHHHHHCC		30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD1A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PSD1A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.