VATA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATA_ARATH
• UniProt AC: O23654
• Protein Name: V-type proton ATPase catalytic subunit A
• Gene Name: VHA-A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 623
• Subcellular Localization: Vacuole membrane ; Peripheral membrane protein .
• Protein Description: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MPAFYGGKLTTFEDDEKESEYGYVRKVSGPVVVADGMAGAAMYELVRVGHDNLIGEIIRLEGDSATIQVYEETAGLTVNDPVLRTHKPLSVELGPGILGNIFDGIQRPLKTIARISGDVYIPRGVSVPALDKDCLWEFQPNKFVEGDTITGGDLYATVFENTLMNHLVALPPDAMGKITYIAPAGQYSLKDTVIELEFQGIKKSYTMLQSWPVRTPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKYSNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREESVMKRTTLVANTSNMPVAAREASIYTGITIAEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGPERNGSVTIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSTALESFYEKFDPDFINIRTKAREVLQREDDLNEIVQLVGKDALAEGDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFYNLANQAVERAAGMDGQKITYTLIKHRLGDLFYRLVSQKFEDPAEGEDTLVEKFKKLYDDLNAGFRALEDETR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPAFYGGKLTTF ---CCCCCCCEECEE	27.37	19880383
10	Phosphorylation	AFYGGKLTTFEDDEK CCCCCEECEECCCCH	32.69	19880383
116	Phosphorylation	LKTIARISGDVYIPR HHHHHHHCCCEEECC	24.32	25561503
120	Phosphorylation	ARISGDVYIPRGVSV HHHCCCEEECCCCCC	15.22	19880383
126	Phosphorylation	VYIPRGVSVPALDKD EEECCCCCCCCCCCC	25.80	19880383
188	Phosphorylation	IAPAGQYSLKDTVIE EEECCCCCCCCEEEE	22.51	19880383
343	Sulfoxidation	IAEYFRDMGYNVSMM HHHHHHHCCCCHHHC	5.52	23289948
349	Sulfoxidation	DMGYNVSMMADSTSR HCCCCHHHCCCCHHH	1.92	23289948
350	Sulfoxidation	MGYNVSMMADSTSRW CCCCHHHCCCCHHHH	2.67	23289948
380	Phosphorylation	ADSGYPAYLAARLAS CCCCCHHHHHHHHHH	7.74	19880383
387	Phosphorylation	YLAARLASFYERAGK HHHHHHHHHHHHCCC	32.71	30291188
599	Phosphorylation	DPAEGEDTLVEKFKK CCCCCCCHHHHHHHH	28.53	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATA_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of VATA_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.