EDE1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDE1_ARATH
• UniProt AC: O80588
• Protein Name: Protein ENDOSPERM DEFECTIVE 1
• Gene Name: EDE1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 474
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
• Protein Description: Microtubule-associated protein required for seed development and for microtubule function in the endosperm. Associates with nuclear microtubules during mitosis. Binds to microtubules of the spindle and spindle-poles and to midzone microtubules out of which the phragmoplast emerges. Not associated with cortical microtubules. Required for endosperm cellularization. May be bound and sequestered by GRF5 in an inactive soluble form during the early stages of mitosis..
• Protein Sequence: MEARIGRSMEHPSTPAINAPAPVPPPSTRRPRVREVSSRFMSPISSSSSSSSSSSAGDLHQLTSNSPRHHHQHQNQRSTSAQRMRRQLKMQEGDENRPSETARSLDSPFPLQQVDGGKNPKQHIRSKPLKENGHRLDTPTTAMLPPPSRSRLNQQRLLTASAATRLLRSSGISLSSSTDGEEDNNNREIFKSNGPDLLPTIRTQAKAFNTPTASPLSRSLSSDDASMFRDVRASLSLKNGVGLSLPPVAPNSKIQADTKKQKKALGQQADVHSLKLLHNRYLQWRFANANAEVKTQSQKAQAERMFYSLGLKMSELSDSVQRKRIELQHLQRVKAVTEIVESQTPSLEQWAVLEDEFSTSLLETTEALLNASLRLPLDSKIKVETKELAEALVVASKSMEGIVQNIGNLVPKTQEMETLMSELARVSGIEKASVEDCRVALLKTHSSQMEECYLRSQLIQHQKKCHQQECTTSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEARIGRSMEHPSTP CCCCCCCCCCCCCCC		19880383
13	Phosphorylation	GRSMEHPSTPAINAP CCCCCCCCCCCCCCC		19880383
27	Phosphorylation	PAPVPPPSTRRPRVR CCCCCCCCCCCCCHH		19880383
28	Phosphorylation	APVPPPSTRRPRVRE CCCCCCCCCCCCHHH		19880383
66	Phosphorylation	LHQLTSNSPRHHHQH HHHHHCCCCCCCCCC		-
104	Phosphorylation	RPSETARSLDSPFPL CCCHHHHCCCCCCCH		22074104
236	Phosphorylation	RDVRASLSLKNGVGL HHHHHHHHCCCCCCC		28011693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	CDC2	P24100	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDE1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDE1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
14335_ARATH	GRF5	physical	21558460

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.