PSD2A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD2A_ARATH
• UniProt AC: Q9SIV2
• Protein Name: 26S proteasome non-ATPase regulatory subunit 2 homolog A
• Gene Name: RPN1A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 891
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). Required during embryogenesis. [PubMed: 16169895 Required for optimal plant growth and stress responses]
• Protein Sequence: MAPTQDPNSVGGGAKKDEATLKVPSKDPKKKDEKKDEDLSEEDLELKQNLELYVERVQDPNPELQKAALESMRQEIRASTSSMTSVPKPLKFLRPHYGTLKAFHETMADSDLKKYLSDILSVLALTMSADGERESLRFRLIGTEGDIGSWGHEYVRNLAGEIAQEYTKRQSEEASIDDLMELVQQIVAFHMKHNAETEAVDLLMDVEDLDLLLEHVDKTNFKRTCNYLTSAARYLPGPDDMLVLDISYMIYMKFEEYPNALQIALFLDNTQYVKQVFTSCTDLLKKKQFCYMIARHGITFELDDEMVADDDDREALQDIVNNTKLSEGYLTLARDIEVMEAKTPEDIYKAHLLDGRASSGASVDSARQNLAATFVNAFVNAGFGQDKLMTVPSDSTTGSSGNWLFKNKEHGKTSAAASLGMIQLWDVDSGLSQLDKYFHSNDNPIIAGALLGVGIVNCGIKNDCDPALALLGDYIDKEDSSVRIGAIMGLGISYAGSQNDQIRNKLSPILNDAKAPLDVIAFASLSLGMIYVGSCNEEVAQSIIFALMDRSEAELGDALTRFLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKYCDMTLLSCAYAGTGNVLKVQDLLAQCGEHLEKGDIHQGPAVLGLAMVAMSEELGVDMEIRSLERMLQYGEQNIRRAVPLALGLLCISNPKVTVMDTLSRLSHDTDSEVAMSAIISLGLIGAGTNNARIAGMLRNLSSYYYKDMSLLFCVRIAQGLVHMGKGLLTLSPFHSERFLLSPTALAGIVTLLHACLDMKPIILGKYHYVLYFLVLAMQPRMMLTVDENLKPLSVPVRVGQAVDVVGQAGRPKTITGFQTHSTPVLLAAGERAELATDKYIPLSPILEGFIILKENPDYREE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	EKKDEDLSEEDLELK CCCCCCCCHHHHHHH		19880383
107	Sulfoxidation	LKAFHETMADSDLKK HHHHHHHHCCHHHHH		25693801
218	Ubiquitination	LLLEHVDKTNFKRTC HHHHHHCCCCHHHHH		20516081
219	Acetylation	LLEHVDKTNFKRTCN HHHHHCCCCHHHHHH		20516081
339	Sulfoxidation	LARDIEVMEAKTPED HHHCCEEEECCCHHH		23289948
358	Phosphorylation	HLLDGRASSGASVDS HCCCCCCCCCCCHHH		25561503
359	Phosphorylation	LLDGRASSGASVDSA CCCCCCCCCCCHHHH		25561503
691	Phosphorylation	PKVTVMDTLSRLSHD CCEEHHHHHHHHCCC		19880383
693	Phosphorylation	VTVMDTLSRLSHDTD EEHHHHHHHHCCCCC		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD2A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD2A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD2A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS4B_ARATH	AT2G20140	physical	20706207
PS10B_ARATH	AT1G45000	physical	20706207
PSD3A_ARATH	EMB2719	physical	20706207
PSDE_ARATH	AT5G23540	physical	20706207
PS12A_ARATH	EMB2107	physical	20706207
PSD11_ARATH	ATS9	physical	20706207
PSMD6_ARATH	AT4G24820	physical	20706207
PRS7A_ARATH	RPT1A	physical	20706207
PRS6B_ARATH	RPT3	physical	20706207
PSD7B_ARATH	MEE34	physical	20706207
PSD1B_ARATH	AT1G04810	physical	20706207
PS13B_ARATH	AT4G19006	physical	20706207
PS6AA_ARATH	RPT5A	physical	20706207
PRS8A_ARATH	RPT6A	physical	20706207
PSD7A_ARATH	RPN8A	physical	20706207
PSD1A_ARATH	AT2G32730	physical	20706207
PS13A_ARATH	AT5G45620	physical	20706207
CDKA1_ARATH	CDC2	physical	20706207
PSD8A_ARATH	RPN12a	physical	20706207
ATP5E_ARATH	AT1G51650	physical	20706207
PP314_ARATH	AT4G16390	physical	20706207
RD23C_ARATH	RAD23C	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.