dbPTM

PS12A_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PS12A_ARATH
UniProt AC	Q9FIB6
Protein Name	26S proteasome non-ATPase regulatory subunit 12 homolog A
Gene Name	RPN5A
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	442
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for gametogenesis and sporophyte development. Acts redundantly with RPN5B..
Protein Sequence	MGDSGKLEATIDRLLNEEKQMRLAENVAGTRKAATEILQLCFDAKDWKLLNEQILNLSKKRGQLKQAVQSMVQQAMQYIDQTPDIETRIELIKTLNNVSAGKIYVEIERARLTKKLAKIKEEQGQIAEAADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDRQDFVRAQILSRKINPRVFDADTKKDKKKPKEGDNMVEEAPADIPTLLELKRIYYELMIRYYSHNNEYIEICRSYKAIYDIPSVKETPEQWIPVLRKICWFLVLAPHDPMQSSLLNATLEDKNLSEIPDFKMLLKQVVTMEVIQWTSLWNKYKDEFEKEKSMIGGSLGDKAGEDLKLRIIEHNILVVSKYYARITLKRLAELLCLSMEEAEKHLSEMVVSKALIAKIDRPSGIVCFQIAKDSNEILNSWAGNLEKLLDLVEKSCHQIHKETMVHKAALRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
4	Phosphorylation	----MGDSGKLEATI ----CCCCHHHHHHH	25561503
393	Phosphorylation	IAKIDRPSGIVCFQI HHHCCCCCCEEEEEE	28011693
404	Phosphorylation	CFQIAKDSNEILNSW EEEEECCCHHHHHHH	30407730
410	Phosphorylation	DSNEILNSWAGNLEK CCHHHHHHHCCCHHH	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PS12A_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PS12A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PS12A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PS12A_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PS12A_ARATH

Related Literatures of Post-Translational Modification