| UniProt ID | PTPRO_HUMAN | |
|---|---|---|
| UniProt AC | Q16827 | |
| Protein Name | Receptor-type tyrosine-protein phosphatase O | |
| Gene Name | PTPRO | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1216 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).. | |
| Protein Sequence | MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | N-linked_Glycosylation | WLFVLFKNATAFHVT HHHHHHCCCEEEEEE | 34.88 | UniProtKB CARBOHYD | |
| 66 (in isoform 4) | Phosphorylation | - | 48.39 | 27251275 | |
| 75 | N-linked_Glycosylation | FFEFEEFNSTLPPPV EEEEEECCCCCCCCE | 37.05 | UniProtKB CARBOHYD | |
| 154 | N-linked_Glycosylation | YNVFTRVNISYWEGK CCEEEEEEEEEECCC | 17.75 | UniProtKB CARBOHYD | |
| 156 | O-linked_Glycosylation | VFTRVNISYWEGKDF EEEEEEEEEECCCCH | 20.99 | 29351928 | |
| 165 | Phosphorylation | WEGKDFRTMLYKDFF ECCCCHHHHHHHHHH | 16.12 | 28270605 | |
| 168 | Phosphorylation | KDFRTMLYKDFFKGK CCHHHHHHHHHHCCC | 9.55 | 28270605 | |
| 189 | N-linked_Glycosylation | LPGMCYSNITFQLVS CCCCCCCCCEEEEEE | 15.73 | UniProtKB CARBOHYD | |
| 201 | N-linked_Glycosylation | LVSEATFNKSTLVEY EEEEEECCCCCEEEE | 32.77 | UniProtKB CARBOHYD | |
| 227 | N-linked_Glycosylation | TAPYPPQNISVRIVN CCCCCCCCEEEEEEE | 33.99 | UniProtKB CARBOHYD | |
| 278 | N-linked_Glycosylation | TPEIPSGNISSGWPD CCCCCCCCCCCCCCC | 34.99 | UniProtKB CARBOHYD | |
| 287 | N-linked_Glycosylation | SSGWPDFNSSDYETT CCCCCCCCCCCCCCC | 48.24 | UniProtKB CARBOHYD | |
| 323 | N-linked_Glycosylation | VLPMEYENNSTLSET EEEEEEECCCCCCCC | 47.02 | UniProtKB CARBOHYD | |
| 324 | N-linked_Glycosylation | LPMEYENNSTLSETE EEEEEECCCCCCCCC | 25.16 | UniProtKB CARBOHYD | |
| 370 | N-linked_Glycosylation | IHIEREENFTEYLMV EEEECCCCCEEEEEE | 44.37 | UniProtKB CARBOHYD | |
| 397 | Phosphorylation | EPGKYKLSVTTFSSS CCCCEEEEEEEECCC | 17.17 | 30576142 | |
| 404 | Phosphorylation | SVTTFSSSGSCETRK EEEEECCCCCEEECC | 33.26 | 30576142 | |
| 461 | N-linked_Glycosylation | TSSQENYNSTIVSVV CCCCCCCCCEEEEEE | 44.23 | UniProtKB CARBOHYD | |
| 485 | Phosphorylation | SQRLEKQYCTQVNSS HHHHHHHHHHHCCCC | 14.45 | 29888752 | |
| 487 | Phosphorylation | RLEKQYCTQVNSSKP HHHHHHHHHCCCCCC | 30.53 | 29888752 | |
| 490 | N-linked_Glycosylation | KQYCTQVNSSKPIIE HHHHHHCCCCCCHHH | 30.65 | UniProtKB CARBOHYD | |
| 491 | Phosphorylation | QYCTQVNSSKPIIEN HHHHHCCCCCCHHHH | 40.66 | 29888752 | |
| 492 | Phosphorylation | YCTQVNSSKPIIENL HHHHCCCCCCHHHHC | 36.93 | 29888752 | |
| 688 | Phosphorylation | SVTRNVMTAILSLPP HHHHCHHHHHHCCCC | 13.28 | 28985074 | |
| 692 | Phosphorylation | NVMTAILSLPPGDIY CHHHHHHCCCCCCEE | 32.49 | 28985074 | |
| 699 | Phosphorylation | SLPPGDIYNLSVTAC CCCCCCEEEEEEEEE | 18.13 | 29759185 | |
| 700 | N-linked_Glycosylation | LPPGDIYNLSVTACT CCCCCEEEEEEEEEE | 26.61 | UniProtKB CARBOHYD | |
| 702 | Phosphorylation | PGDIYNLSVTACTER CCCEEEEEEEEEECC | 17.49 | 29759185 | |
| 711 | Phosphorylation | TACTERGSNTSMLRL EEEECCCCCCCEEEE | 43.06 | 22210691 | |
| 712 | N-linked_Glycosylation | ACTERGSNTSMLRLV EEECCCCCCCEEEEE | 38.71 | UniProtKB CARBOHYD | |
| 733 | N-linked_Glycosylation | PKSLFAVNKTQTSVT CCCEEEEECCCCEEE | 37.92 | UniProtKB CARBOHYD | |
| 840 | Phosphorylation | LIGLLLVTLIILRKK HHHHHHHHHHHHHHH | 16.53 | - | |
| 859 | Phosphorylation | ARECGAGTFVNFASL HHHCCCCCEEEHHHC | 24.71 | 27486199 | |
| 865 | Phosphorylation | GTFVNFASLERDGKL CCEEEHHHCCCCCCC | 26.99 | 29759185 | |
| 877 | Phosphorylation | GKLPYNWRRSIFAFL CCCCCCHHHHHHHHH | 20.87 | 27251275 | |
| 877 (in isoform 2) | Phosphorylation | - | 20.87 | 27251275 | |
| 928 | Ubiquitination | DDFDAYIKDMAKDSD HHHHHHHHHHHHCCC | 28.86 | - | |
| 1181 | Phosphorylation | YRMSMVQTEEQYIFI HCCCCCCCHHHHHHH | 30.03 | - | |
| 1185 | Phosphorylation | MVQTEEQYIFIHQCV CCCCHHHHHHHHHHH | 10.90 | - | |
| 1206 | Phosphorylation | KKQQFCISDVIYENV HCCCEEEHHHHHHCC | 27.32 | 24719451 | |
| 1210 | Phosphorylation | FCISDVIYENVSKS- EEEHHHHHHCCCCC- | 10.99 | 25884760 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTPRO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTPRO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTPRO_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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