PRP1_SCHPO - dbPTM
PRP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP1_SCHPO
UniProt AC Q12381
Protein Name Pre-mRNA-splicing factor prp1
Gene Name prp1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 906
Subcellular Localization Nucleus .
Protein Description Involved in pre-mRNA splicing. Interacts with prp6 and prp13. May also be involved in the regulation of the G0-G1/G2 transition. Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region..
Protein Sequence MANFYPDFLNMQPPPNYVAGLGRGATGFTTRSDLGPAQELPSQESIKAAIEQRKSEIEEEEDIDPRYQDPDNEVALFATAPYDHEDEEADKIYQSVEEHLSKRRKSQREKQEQLQKEKYEKENPKVSSQFADLKRGLSTLTDEDWNNIPEPGDLTRKKRTKQPRRERFYATSDFVLASARNENQAISNFAVDTQAGTETPDMNGTKTNFVEIGAARDKVLGIKLAQASSNLTSPSTIDPKGYLTSLNSMVPKNANDLGDIRKARKLLQSVIETNPKHASGWVAAARLEEVANKLSQAQSLILKGCENCSRSEDVWLEAIRLHPAAEAKVIIANAVKKLPKSVTLWLEAEKLENQAQHKKRIIKKALEFNPTSVSLWKEAVNLEEEVDNARILLARAVELIPMSIDLWLALARLETYENAKKVLNKARQTIRTSHEVWIAAARLEEQQGNVSRVEKIMARGVSELQATGGMLQRDQWLSEAEKCETEGAVITAQAIINTCLGVGLDEEDQFDTWLDDAQSFIARKCIDCARAVFAFSLRVYPKSEKLWLRAVELEKLYGTTESVCSILEKAVESCPKAEILWLLYAKERKNVNDIAGARNILGRAFEYNSNSEEIWLAAVRIEFVNNENERARKLLARARIESGTERIWTKSISLERILDEKDRALQLLENALKIYPHYDKLYMMKGQIFEDKEQIELARDAYLAGTKVCPYSIPLWLLLAKLEEKQSVIRARVVFDRAKVKNPKNEFLWLELIKMELRAGNISQVRAALAKALQECPSSGLLWTEAIWLEPRAQRKTRATDALRKCEGNAHLLCTIARMLWLEKKADKARSWFLKAVKADQDNGDVWCWFYKYSLEAGNEDQQKEVLTSFETADPHHGYFWPSITKDIKNSRKTPQELLHLAINVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
207PhosphorylationPDMNGTKTNFVEIGA
CCCCCCCCCCEEECC		33.4524763107
232PhosphorylationAQASSNLTSPSTIDP
EHHCCCCCCCCCCCC		42.7324763107
235PhosphorylationSSNLTSPSTIDPKGY
CCCCCCCCCCCCCCH		37.4528889911
236PhosphorylationSNLTSPSTIDPKGYL
CCCCCCCCCCCCCHH		32.5529996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRP4_SCHPOprp4genetic
9286671
SPP42_SCHPOspp42genetic
16133344
BRR2_SCHPObrr2genetic
16133344
PRP4_SCHPOprp4physical
11252721
RSMB_SCHPOsmb1physical
15755920
SMD1_SCHPOsmd1physical
15755920
SMD2_SCHPOsmd2physical
15755920
SMD3_SCHPOsmd3physical
15755920
RUXE_SCHPOsme1physical
15755920
RUXF_SCHPOsmf1physical
15755920
RUXG_SCHPOsmg1physical
15755920
RU2B_SCHPOmsl1physical
15755920
SAP61_SCHPOsap61physical
15755920
SAP62_SCHPOsap62physical
15755920
SA114_SCHPOsap114physical
15755920
SAP49_SCHPOsap49physical
15755920
SA145_SCHPOsap145physical
15755920
RSE1_SCHPOprp12physical
15755920
SF3B1_SCHPOprp10physical
15755920
SPP42_SCHPOspp42physical
15755920
BRR2_SCHPObrr2physical
15755920
SN114_SCHPOcwf10physical
15755920
CWF17_SCHPOspf38physical
15755920
PRP1_SCHPOprp1physical
15755920
PRP3_SCHPOprp3physical
15755920
YIDC_SCHPOrna4physical
15755920
SNU66_SCHPOsnu66physical
15755920
PRP31_SCHPOprp31physical
15755920
SPF30_SCHPOspf30physical
15755920
DED1_SCHPOsum3physical
15755920
DIMI_SCHPOdim1physical
15755920
BRR2_SCHPObrr2physical
16133344
PRP31_SCHPOprp31physical
16133344
MOK14_SCHPOmok14genetic
22681890
YE7A_SCHPOSPAC4A8.10genetic
22681890
MDE5_SCHPOmde5genetic
22681890
NSE6_SCHPOnse6genetic
22681890
RNP24_SCHPOrnp24genetic
22681890
YNVB_SCHPOSPBC3H7.11genetic
22681890
YE88_SCHPOSPAC9G1.08cgenetic
22681890
TR852_SCHPOtrs8502genetic
22681890
YC93_SCHPOSPCC584.03cgenetic
22681890
ALG12_SCHPOalg12genetic
22681890
VTS1_SCHPOSPBC13E7.03cgenetic
22681890
SWI6_SCHPOswi6genetic
22681890
UPP2_SCHPOSPAC1399.04cgenetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
ALP16_SCHPOalp16genetic
22681890
STR3_SCHPOstr3genetic
22681890
UTP16_SCHPOutp16genetic
22681890
EIF2A_SCHPOSPBC4B4.04genetic
22681890
RS12B_SCHPOrps1202genetic
22681890
PFD2_SCHPOSPAC227.10genetic
22681890
VPS1_SCHPOvps1genetic
22681890
YAKB_SCHPOSPAC1F7.11cgenetic
22681890
YH5B_SCHPOSPBC215.11cgenetic
22681890
APT_SCHPOapt1genetic
22681890
GYP7_SCHPOgyp7genetic
22681890
TIM21_SCHPOtim21genetic
22681890
EXO5_SCHPOexo5genetic
22681890
EIF3J_SCHPOSPAC3A12.13cgenetic
22681890
MTNA_SCHPOSPBC23E6.10cgenetic
22681890
VIP1_SCHPOasp1genetic
22681890
HSP33_SCHPOhsp3103genetic
22681890
MTO1_SCHPOSPBC30B4.06cgenetic
22681890
PPK8_SCHPOppk8genetic
22681890
YC58_SCHPOSPCC1259.08genetic
22681890
CLR4_SCHPOclr4genetic
22681890
YGV4_SCHPOSPBC354.04genetic
22681890
YBN2_SCHPOSPBC8E4.02cgenetic
22681890
SPP1_SCHPOspf1genetic
22681890
PPA1_SCHPOpho1genetic
22681890
MBO1_SCHPOmto1genetic
22681890
SWD1_SCHPOswd1genetic
22681890
OBP1_SCHPOSPBC646.08cgenetic
22681890
SHY1_SCHPOshy1genetic
22681890
GIT3_SCHPOgit3genetic
22681890
PPK4_SCHPOire1genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
OYEA_SCHPOSPAC5H10.04genetic
22681890
YBD4_SCHPOdbl6genetic
22681890
YETB_SCHPOfra2genetic
22681890
POM1_SCHPOpom1genetic
22681890
ELY5_SCHPOely5genetic
22681890
GCN1_SCHPOSPAC18G6.05cgenetic
22681890
TEA2_SCHPOtea2genetic
22681890
PPK35_SCHPOmug27genetic
22681890
YET4_SCHPOSPAC8C9.04genetic
22681890
MUG37_SCHPOmug37genetic
22681890
PUT2_SCHPOSPBC24C6.04genetic
22681890
ATP14_SCHPOatp14genetic
22681890
TGCE1_SCHPOSPCC1672.09genetic
22681890
YIV1_SCHPOSPAC144.01genetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
PYRD_SCHPOura3genetic
22681890
VPS3_SCHPOvps3genetic
22681890
YD49_SCHPOSPAC22H10.09genetic
22681890
PTF2_SCHPOptf2genetic
22681890
YA7D_SCHPOSPAC24H6.13genetic
22681890
CASP_SCHPOcoy1genetic
22681890
CUE5_SCHPOSPBC16E9.02cgenetic
22681890
EME1_SCHPOeme1genetic
22681890
YCY3_SCHPOcue2genetic
22681890
TRM82_SCHPOSPCC18.13genetic
22681890
PFL7_SCHPOpfl7genetic
22681890
CIF1_SCHPOcif1genetic
22681890
RGA6_SCHPOrga6genetic
22681890
YD22_SCHPOSPAC56F8.02genetic
22681890
DAD2_SCHPOdad2genetic
22681890
YBE3_SCHPOSPBC17D11.03cgenetic
22681890
SPF31_SCHPOspf31genetic
22681890
TLG3_SCHPOptl1genetic
22681890
YA99_SCHPOSPAC13G6.09genetic
22681890
GAL1_SCHPOgal1genetic
22681890
PPK25_SCHPOppk25genetic
22681890
TREA_SCHPOntp1genetic
22681890
IMA2_SCHPOimp1genetic
22681890
PPK6_SCHPOppk6genetic
22681890
YG0C_SCHPOSPBC1604.12genetic
22681890
YC0H_SCHPOSPCC4G3.17genetic
22681890
RL9A_SCHPOrpl901genetic
22681890
CUF2_SCHPOcuf2genetic
22681890
YAD3_SCHPOSPAC4G8.03cgenetic
22681890
AREH2_SCHPOare2genetic
22681890
YKJ7_SCHPOSPAC513.07genetic
22681890
YFFE_SCHPOSPAC1687.14cgenetic
22681890
YHM3_SCHPOSPBC1271.03cgenetic
22681890
YOX1_SCHPOyox1genetic
22681890
YIY3_SCHPOSPAC22F8.03cgenetic
22681890
LIN1_SCHPOlin1physical
26771498
DIMI_SCHPOdim1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235, AND MASSSPECTROMETRY.

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