SAP61_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAP61_SCHPO
• UniProt AC: O59706
• Protein Name: Pre-mRNA-splicing factor sap61
• Gene Name: sap61
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 492
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome..
• Protein Sequence: MSESVLETERYAHEELERLQQAIVDRQVANPKAPRERLRLEHQSAQFLNQFRETSKKLLVSHESSDRLKDQEVARINADDDLTEFYKSLGEIQEFHKKYPDHKVEDLSQLYSIKPSQPGIDEIDTLFRGEEMYGRFMDLNECYEEYINLSNVQHISYLEYLKNLEDFDQIPKPEKNQTYINYITHLYEYLVSFYRRTHPLSNLDKIIAVFDTEFDAAWEAGLPGWYSHNAEAEKDGKDSTEAFYCEVCQKFFGKITVFEAHKKSKAHNKAVKRMQSSSPSTTSNTNEKQKGPKAIARIEFLIKKLTSLLDDVRKDTRENVVRRQTLTAAERLAEVEAAEREAFEQSTPSVSVEGNQDEESDQDDEEKIYNPLKLPLGWDGKPIPFWLWKLHGLGKEFPCEICGNYVYMGRKAFDKHFTEQRHIYGLKCLGISPSPLFNQITSIDEALQLWQKYKVDSKKRETTMASLNEMEDDEGNVMSEKVYNDLKAQGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	KLLVSHESSDRLKDQ HHHHCCCCCCHHCHH	31.92	21712547
277	Phosphorylation	AVKRMQSSSPSTTSN HHHHHHHCCCCCCCC	29.40	21712547
278	Phosphorylation	VKRMQSSSPSTTSNT HHHHHHCCCCCCCCC	28.28	24763107
360	Phosphorylation	EGNQDEESDQDDEEK CCCCCCCCCCCCHHH	38.23	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAP61_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAP61_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAP61_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YOI5_SCHPO	SPBC1778.05c	genetic	22681890
POF3_SCHPO	pof3	genetic	22681890

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY.
PubMed: 18257517