| UniProt ID | VPS5_SCHPO | |
|---|---|---|
| UniProt AC | Q9C0U7 | |
| Protein Name | Vacuolar protein sorting-associated protein vps5 | |
| Gene Name | vps5 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 576 | |
| Subcellular Localization |
Cytoplasm . Golgi apparatus . Membrane Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Required for efficient sporulation target of PtdIns(3)P in vesicle transport required for onset of the forespore membrane formation.; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.. | |
| Protein Sequence | MLGHNIYEEDDAFNPFADSVSPLNPPKTDQEPSAEGVEEESPNVQASPPKTHIYTSPRKRSVNLKSLPFETLTLDSAPLGPLQFSDAPSMAPENNRLEVGLNTKINPLKGSSPALNADFSANKPWISEVNSFSPSPIGATENPTIPNSEQTVDTLDAASSSAPNFTHTVSSASSQKQGSTSLTDTENQKAHPAAAPQSLTPFYIQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLSNNHPGCIIPPIPEKQVVGRFDDEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETFDPRMTHRTTLIESSSSPLRSGPSTSGLLDSFTSAFHTSGSSKFSEQDPILIEAKDTLDSLETQLKSVYHALLLSIDQRIQFASAIHDFGEAVGNLSLVDLEPTLSSKFDGLSQLQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAKNAFTTRQKLWQTWQSSVQAVSRAKTQLEKCKKQAKSQQKSLPYLEEQYEKYRAKAADLEKEFSESTTLLKRDLSSLTTSRVDDLKASVETWLESAIESQKEIIERWESFLDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | AEGVEEESPNVQASP CCCCCCCCCCCCCCC | 25.67 | 29996109 | |
| 47 | Phosphorylation | ESPNVQASPPKTHIY CCCCCCCCCCCCEEE | 25.33 | 28889911 | |
| 54 | Phosphorylation | SPPKTHIYTSPRKRS CCCCCEEECCCCCCC | 8.12 | 25720772 | |
| 55 | Phosphorylation | PPKTHIYTSPRKRSV CCCCEEECCCCCCCC | 31.48 | 28889911 | |
| 56 | Phosphorylation | PKTHIYTSPRKRSVN CCCEEECCCCCCCCC | 13.02 | 24763107 | |
| 61 | Phosphorylation | YTSPRKRSVNLKSLP ECCCCCCCCCCCCCC | 20.56 | 21712547 | |
| 111 | Phosphorylation | KINPLKGSSPALNAD CCCCCCCCCCCCCCC | 31.40 | 24763107 | |
| 151 | Phosphorylation | TIPNSEQTVDTLDAA CCCCCCCCHHHHHHH | 19.12 | 27738172 | |
| 179 | Phosphorylation | ASSQKQGSTSLTDTE CCCCCCCCCCCCCCC | 16.60 | 21712547 | |
| 330 | Phosphorylation | RTTLIESSSSPLRSG EEEEEECCCCCCCCC | 23.26 | 29996109 | |
| 331 | Phosphorylation | TTLIESSSSPLRSGP EEEEECCCCCCCCCC | 45.30 | 29996109 | |
| 332 | Phosphorylation | TLIESSSSPLRSGPS EEEECCCCCCCCCCC | 29.87 | 28889911 | |
| 339 | Phosphorylation | SPLRSGPSTSGLLDS CCCCCCCCCCCHHHH | 38.44 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS5_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS5_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS5_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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