FGF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF8_HUMAN
• UniProt AC: P55075
• Protein Name: Fibroblast growth factor 8
• Gene Name: FGF8
• Organism: Homo sapiens (Human).
• Sequence Length: 233
• Subcellular Localization: Secreted.
• Protein Description: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. [PubMed: 16384934]
• Protein Sequence: MGSPRSALSCLLLHLLVLCLQAQEGPGRGPALGRELASLFRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	IRTYQLYSRTSGKHV HHHHHHHCCCCCCCE	37.36	24719451
78	Phosphorylation	TYQLYSRTSGKHVQV HHHHHCCCCCCCEEE	35.57	22964224
79	Phosphorylation	YQLYSRTSGKHVQVL HHHHCCCCCCCEEEE	44.74	22964224
155	N-linked_Glycosylation	TEIVLENNYTALQNA EEEEEECCEEEHHCC	26.59	UniProtKB CARBOHYD
172	Phosphorylation	EGWYMAFTRKGRPRK CEEEEEEEECCCCCC	23.18	24719451
183	Phosphorylation	RPRKGSKTRQHQREV CCCCCCCCHHHHHHH	36.94	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGF8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TT30A_HUMAN	TTC30A	physical	28514442
IFT80_HUMAN	IFT80	physical	28514442
IFT88_HUMAN	IFT88	physical	28514442
F91A1_HUMAN	FAM91A1	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
IFT52_HUMAN	IFT52	physical	28514442
IFT57_HUMAN	IFT57	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
H1T_HUMAN	HIST1H1T	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
WDR3_HUMAN	WDR3	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
IFT74_HUMAN	IFT74	physical	28514442
XRN1_HUMAN	XRN1	physical	28514442
NOA1_HUMAN	NOA1	physical	28514442
DDX55_HUMAN	DDX55	physical	28514442
RRP5_HUMAN	PDCD11	physical	28514442
IF172_HUMAN	IFT172	physical	28514442
WDR11_HUMAN	WDR11	physical	28514442
H2AX_HUMAN	H2AFX	physical	28514442
WDR36_HUMAN	WDR36	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
DDX18_HUMAN	DDX18	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
PWP2_HUMAN	PWP2	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
DAXX_HUMAN	DAXX	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
CDK12_HUMAN	CDK12	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
ZFR_HUMAN	ZFR	physical	28514442
CK057_HUMAN	C11orf57	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
NPA1P_HUMAN	URB1	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
CD11B_HUMAN	CDK11B	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
DHX36_HUMAN	DHX36	physical	28514442
PRR3_HUMAN	PRR3	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
BMS1_HUMAN	BMS1	physical	28514442
STRBP_HUMAN	STRBP	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
ZC3H8_HUMAN	ZC3H8	physical	28514442
NJMU_HUMAN	C17orf75	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
RBMS1_HUMAN	RBMS1	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
NOL8_HUMAN	NOL8	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
SRPK1_HUMAN	SRPK1	physical	28514442
NVL_HUMAN	NVL	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
TRM1L_HUMAN	TRMT1L	physical	28514442
AATF_HUMAN	AATF	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
MPP10_HUMAN	MPHOSPH10	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
RT30_HUMAN	MRPS30	physical	28514442
CHERP_HUMAN	CHERP	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
NAT10_HUMAN	NAT10	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
RS16_HUMAN	RPS16	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
SDA1_HUMAN	SDAD1	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
VANG1_HUMAN	VANGL1	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
NSUN4_HUMAN	NSUN4	physical	28514442
KRR1_HUMAN	KRR1	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.