dbPTM

SYUA_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYUA_RAT
UniProt AC	P37377
Protein Name	Alpha-synuclein
Gene Name	Snca
Organism	Rattus norvegicus (Rat).
Sequence Length	140
Subcellular Localization	Cytoplasm, cytosol . Membrane . Nucleus . Cell junction, synapse . Secreted .
Protein Description	May be involved in the regulation of dopamine release and transport..
Protein Sequence	MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPSSEAYEMPSEEGYQDYEPEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVFMKGL -------CCCCHHHH	10.01	-
6	Acetylation	--MDVFMKGLSKAKE --CCCCHHHHHHHHH	45.28	22902405
34	Acetylation	AEAAGKTKEGVLYVG HHHCCCCCCEEEEEC	56.83	22902405
34	Ubiquitination	AEAAGKTKEGVLYVG HHHCCCCCCEEEEEC	56.83	-
39	Phosphorylation	KTKEGVLYVGSKTKE CCCCEEEEECCCCCC	10.60	28432305
42	Phosphorylation	EGVLYVGSKTKEGVV CEEEEECCCCCCCEE	27.40	28432305
43	Ubiquitination	GVLYVGSKTKEGVVH EEEEECCCCCCCEEE	58.65	-
45	Acetylation	LYVGSKTKEGVVHGV EEECCCCCCCEEEEE	57.09	22902405
72	O-linked_Glycosylation	NVGGAVVTGVTAVAQ CCCCEEEECCEEEEE	21.24	20676199
96	Ubiquitination	AAATGFVKKDQMGKG HHHCCCEEHHHCCCC	48.66	-
96	Acetylation	AAATGFVKKDQMGKG HHHCCCEEHHHCCCC	48.66	22902405
121	Phosphorylation	EDMPVDPSSEAYEMP CCCCCCCCCCCCCCC	36.03	22673903
122	Phosphorylation	DMPVDPSSEAYEMPS CCCCCCCCCCCCCCC	31.47	22673903
125	Phosphorylation	VDPSSEAYEMPSEEG CCCCCCCCCCCCCCC	14.54	22673903
129	Phosphorylation	SEAYEMPSEEGYQDY CCCCCCCCCCCCCCC	47.14	22673903
133	Phosphorylation	EMPSEEGYQDYEPEA CCCCCCCCCCCCCCC	11.07	22673903
136	Phosphorylation	SEEGYQDYEPEA--- CCCCCCCCCCCC---	20.18	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
125	Y	Phosphorylation	Kinase	FYN	Q62844	Uniprot
129	S	Phosphorylation	Kinase	PLK2	Q9R012	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Siah2	Q8R4T2	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1	M	Acetylation		-
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYUA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433B_RAT	Ywhab	physical	10407019
KPCE_RAT	Prkce	physical	10407019
KPCG_RAT	Prkcg	physical	10407019
RAF1_RAT	Raf1	physical	10407019
MP2K1_RAT	Map2k1	physical	10407019
TY3H_RAT	Th	physical	11943812
SIAH1_RAT	Siah1	physical	18065497
SC6A3_RAT	Slc6a3	physical	17873367
PP2AA_RAT	Ppp2ca	physical	16030137
VGLU1_RAT	Slc17a7	physical	16306404
PARK7_RAT	Park7	physical	16854843
ENPL_RAT	Hsp90b1	physical	16854843
CALX_RAT	Canx	physical	16854843
CLH1_RAT	Cltc	physical	16854843
KLC1_RAT	Klc1	physical	16176937
DYL1_RAT	Dynll1	physical	16176937
MCTS1_RAT	Mcts1	physical	16854843
HAP28_RAT	Pdap1	physical	16854843
CPSF5_RAT	Nudt21	physical	16854843
RS11_RAT	Rps11	physical	16854843
OSCP1_RAT	Oscp1	physical	16854843
RS14_RAT	Rps14	physical	16854843
RS3_RAT	Rps3	physical	16854843
CH60_RAT	Hspd1	physical	16854843
RL17_RAT	Rpl17	physical	16854843
ACTS_RAT	Acta1	physical	16854843
ACTC_RAT	Actc1	physical	16854843
ARP2_RAT	Actr2	physical	16854843
ABCD2_RAT	Abcd2	physical	16854843
ALDOC_RAT	Aldoc	physical	16854843
ATPA_RAT	Atp5a1	physical	16854843
ACLY_RAT	Acly	physical	16854843
BASP1_RAT	Basp1	physical	16854843
CALR_RAT	Calr	physical	16854843
SEPT7_RAT	Sept7	physical	16854843
TCPG_RAT	Cct3	physical	16854843
TCPD_RAT	Cct4	physical	16854843
DYHC1_RAT	Dync1h1	physical	16854843
EF1A1_RAT	Eef1a1	physical	16854843
SRSF2_RAT	Srsf2	physical	16854843
HMGB1_RAT	Hmgb1	physical	16854843
RS23_RAT	Rps23	physical	16854843
ROA3_RAT	Hnrnpa3	physical	16854843
RS2_RAT	Rps2	physical	16854843
H15_RAT	Hist1h1b	physical	16854843
RS7_RAT	Rps7	physical	16854843
RS8_RAT	Rps8	physical	16854843
RL11_RAT	Rpl11	physical	16854843
RS6_RAT	Rps6	physical	16854843
DNJA1_RAT	Dnaja1	physical	16854843
RS18_RAT	Rps18	physical	16854843
MLP3B_RAT	Map1lc3b	physical	16854843
HSP7C_RAT	Hspa8	physical	16854843
PPIB_RAT	Ppib	physical	16854843
RL21_RAT	Rpl21	physical	16854843
RL19_RAT	Rpl19	physical	16854843
RL30_RAT	Rpl30	physical	16854843
IF2A_RAT	Eif2s1	physical	16854843
IF5A1_RAT	Eif5a	physical	16854843
GSK3B_RAT	Gsk3b	physical	16854843
GBB1_RAT	Gnb1	physical	16854843
H14_RAT	Hist1h1d	physical	16854843
HS90B_RAT	Hsp90ab1	physical	16854843
HS90A_RAT	Hsp90aa1	physical	16854843
HSP74_RAT	Hspa4	physical	16854843
HNRH1_RAT	Hnrnph1	physical	16854843
ARP3_RAT	Actr3	physical	16854843
DC1L1_RAT	Dync1li1	physical	16854843
RTCB_RAT	Rtcb	physical	16854843
IMB1_RAT	Kpnb1	physical	16854843

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYUA_RAT

Related Literatures of Post-Translational Modification

show