MLP3B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLP3B_RAT
• UniProt AC: Q62625
• Protein Name: Microtubule-associated proteins 1A/1B light chain 3B
• Gene Name: Map1lc3b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 142
• Subcellular Localization: Cytoplasm, cytoskeleton . Endomembrane system ; Lipid-anchor . Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Cytoplasmic vesicle, autophagosome . LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ci
• Protein Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway..
• Protein Sequence: MPSEKTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESERDEDGFLYMVYASQETFGTALAVTYMSALKATATGREPCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KTFKQRRSFEQRVED HHHHHHHCHHHHHHH	35.01	-
51	Acetylation	LPVLDKTKFLVPDHV CCCCCCCCCCCCCCC	42.30	22902405
120	Phosphatidylethanolamine amidation	YASQETFGTALAVTY EECCCCHHHHHHHHH	19.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
12	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
12	S	Phosphorylation	Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLP3B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA1A_RAT	Tuba1a	physical	7908909
SQSTM_MOUSE	Sqstm1	physical	27442348

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.