ROA3_RAT - dbPTM
ROA3_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ROA3_RAT
UniProt AC Q6URK4
Protein Name Heterogeneous nuclear ribonucleoprotein A3
Gene Name Hnrnpa3
Organism Rattus norvegicus (Rat).
Sequence Length 379
Subcellular Localization Nucleus. Component of ribonucleosomes..
Protein Description Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing..
Protein Sequence MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEVKPPPG
-------CCCCCCCC		13.91-
4Acetylation----MEVKPPPGRPQ
----CCCCCCCCCCC		38.2022902405
7 (in isoform 2)Acetylation-61.01-
14PhosphorylationPGRPQPDSGRRRRRR
CCCCCCCCCHHHHHC		40.6627097102
43PhosphorylationKLFIGGLSFETTDDS
HHHHCCCCCCCCCHH		25.0627097102
46PhosphorylationIGGLSFETTDDSLRE
HCCCCCCCCCHHHHH		33.2523984901
47PhosphorylationGGLSFETTDDSLREH
CCCCCCCCCHHHHHH		30.5223984901
52MethylationETTDDSLREHFEKWG
CCCCHHHHHHHHHHC		39.02-
76MethylationDPQTKRSRGFGFVTY
CCCCCCCCCCEEEEE		48.79-
112PhosphorylationVEPKRAVSREDSVKP
CCCCCCCCCHHCCCC		29.0327097102
116PhosphorylationRAVSREDSVKPGAHL
CCCCCHHCCCCCCEE		27.5629779826
124PhosphorylationVKPGAHLTVKKIFVG
CCCCCEEEEEEEEEC		22.0325575281
126AcetylationPGAHLTVKKIFVGGI
CCCEEEEEEEEECCC		34.6125786129
134AcetylationKIFVGGIKEDTEEYN
EEEECCCCCCCCCCC		53.46-
165AcetylationMEDRQSGKKRGFAFV
EEHHHCCCCCEEEEE		44.5422902405
179PhosphorylationVTFDDHDTVDKIVVQ
EECCCCCCCEEEEEE		27.4723984901
190PhosphorylationIVVQKYHTINGHNCE
EEEEEECCCCCCCHH		17.0423984901
214Asymmetric dimethylarginineMQSAGSQRGRGGGSG
HHHHCCCCCCCCCCC		38.17-
214MethylationMQSAGSQRGRGGGSG
HHHHCCCCCCCCCCC		38.1724098712
216Asymmetric dimethylarginineSAGSQRGRGGGSGNF
HHCCCCCCCCCCCCC		42.65-
216MethylationSAGSQRGRGGGSGNF
HHCCCCCCCCCCCCC		42.6524098712
226Asymmetric dimethylarginineGSGNFMGRGGNFGGG
CCCCCCCCCCCCCCC		37.75-
226MethylationGSGNFMGRGGNFGGG
CCCCCCCCCCCCCCC		37.7524098712
239Asymmetric dimethylarginineGGGGNFGRGGNFGGR
CCCCCCCCCCCCCCC		45.79-
239MethylationGGGGNFGRGGNFGGR
CCCCCCCCCCCCCCC		45.7924098712
246Asymmetric dimethylarginineRGGNFGGRGGYGGGG
CCCCCCCCCCCCCCC		35.42-
246MethylationRGGNFGGRGGYGGGG
CCCCCCCCCCCCCCC		35.4224098712
257MethylationGGGGGGSRGSYGGGD
CCCCCCCCCCCCCCC		41.15-
286MethylationGGPGYSSRGGYGGGG
CCCCCCCCCCCCCCC		36.2924098712
286Asymmetric dimethylarginineGGPGYSSRGGYGGGG
CCCCCCCCCCCCCCC		36.29-
351PhosphorylationYGPMKGGSFGGRSSG
CCCCCCCCCCCCCCC		29.4128689409
355MethylationKGGSFGGRSSGSPYG
CCCCCCCCCCCCCCC		28.20-
356PhosphorylationGGSFGGRSSGSPYGG
CCCCCCCCCCCCCCC		42.1828689409
357PhosphorylationGSFGGRSSGSPYGGG
CCCCCCCCCCCCCCC		41.7623712012
359PhosphorylationFGGRSSGSPYGGGYG
CCCCCCCCCCCCCCC		19.5223712012
361PhosphorylationGRSSGSPYGGGYGSG
CCCCCCCCCCCCCCC		30.0527097102
365PhosphorylationGSPYGGGYGSGGGSG
CCCCCCCCCCCCCCC		16.0527097102
367PhosphorylationPYGGGYGSGGGSGGY
CCCCCCCCCCCCCCC		26.2727097102
371PhosphorylationGYGSGGGSGGYGSRR
CCCCCCCCCCCCCCC		32.1127097102
374PhosphorylationSGGGSGGYGSRRF--
CCCCCCCCCCCCC--		18.5628689409
376PhosphorylationGGSGGYGSRRF----
CCCCCCCCCCC----		16.2927097102
377MethylationGSGGYGSRRF-----
CCCCCCCCCC-----		39.3918966659
378MethylationSGGYGSRRF------
CCCCCCCCC------		43.24-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ROA3_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ROA3_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ROA3_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ROA3_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ROA3_RAT

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-376, ANDMASS SPECTROMETRY.

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