CALR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALR_RAT
• UniProt AC: P18418
• Protein Name: Calreticulin
• Gene Name: Calr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 416
• Subcellular Localization: Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen .
• Protein Description: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis..
• Protein Sequence: MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPGGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDEDDRDEDEDEEDEKEEDEEDATGQAKDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Acetylation	TNRWVESKHKSDFGK HHHHHHHCCHHHCCC	41.36	22902405
48	Acetylation	KHKSDFGKFVLSSGK CCHHHCCCEEECCCC	32.09	22902405
55	Acetylation	KFVLSSGKFYGDQEK CEEECCCCCCCCCCC	37.04	22902405
62	Acetylation	KFYGDQEKDKGLQTS CCCCCCCCCCCCCCC	60.14	22902405
62	Succinylation	KFYGDQEKDKGLQTS CCCCCCCCCCCCCCC	60.14	26843850
64	Succinylation	YGDQEKDKGLQTSQD CCCCCCCCCCCCCHH	73.00	26843850
151	Acetylation	VHVIFNYKGKNVLIN EEEEEEECCCEEEEC	65.59	22902405
159	Acetylation	GKNVLINKDIRCKDD CCEEEECCCCCCCCC	47.76	22902405
206	Acetylation	DWDFLPPKKIKDPDA CCCCCCCCCCCCCCC	66.25	22902405
209	Acetylation	FLPPKKIKDPDAAKP CCCCCCCCCCCCCCC	72.58	22902405
209	Succinylation	FLPPKKIKDPDAAKP CCCCCCCCCCCCCCC	72.58	26843850
215	Acetylation	IKDPDAAKPEDWDER CCCCCCCCCCCCCHH	51.14	22902405
229	Phosphorylation	RAKIDDPTDSKPEDW HHCCCCCCCCCCCCC	60.96	22673903
231	Phosphorylation	KIDDPTDSKPEDWDK CCCCCCCCCCCCCCC	53.22	22673903
232	Acetylation	IDDPTDSKPEDWDKP CCCCCCCCCCCCCCC	56.06	22902405
238	Succinylation	SKPEDWDKPEHIPDP CCCCCCCCCCCCCCC	48.31	26843850
238	Acetylation	SKPEDWDKPEHIPDP CCCCCCCCCCCCCCC	48.31	22902405
368	Acetylation	QDEEQRLKEEEEDKK HHHHHHHHHHHHHHH	66.33	22902405
374	Acetylation	LKEEEEDKKRKEEEE HHHHHHHHHHHHHHH	58.73	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALR_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALR_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBRAP_RAT	Gabarap	physical	17916189

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.