H15_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H15_RAT
• UniProt AC: D3ZBN0
• Protein Name: Histone H1.5
• Gene Name: Hist1h1b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 222
• Subcellular Localization: Nucleus. Chromosome. Mainly localizes in heterochromatin..
• Protein Description: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)..
• Protein Sequence: MSETAPAETTAPAPVEKSPAKKKTKKAGAAKRKATGPPVSELITKAVSASKERGGVSLPALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKVASGEAKPKAKKTGAAKAKKPTGATPKKPKKTAGAKKTVKKTPKKAKKPAAAGVKKVTKSPKKAKAAAKPKKATKSPARPKAVKSKASKPKVTKPKAAKPKAAKVKKAVSKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSETAPAET ------CCCCCCCCC		27097102
2	Acetylation	------MSETAPAET ------CCCCCCCCC		-
4	Phosphorylation	----MSETAPAETTA ----CCCCCCCCCCC		27097102
9	Phosphorylation	SETAPAETTAPAPVE CCCCCCCCCCCCCCC		27097102
10	Phosphorylation	ETAPAETTAPAPVEK CCCCCCCCCCCCCCC		27097102
17	Acetylation	TAPAPVEKSPAKKKT CCCCCCCCCCCCHHC		22902405
18	Phosphorylation	APAPVEKSPAKKKTK CCCCCCCCCCCHHCC		27097102
26	Acetylation	PAKKKTKKAGAAKRK CCCHHCCHHHHHHHH		-
26	Methylation	PAKKKTKKAGAAKRK CCCHHCCHHHHHHHH		-
33	Succinylation	KAGAAKRKATGPPVS HHHHHHHHCCCCCHH		-
33	Succinylation	KAGAAKRKATGPPVS HHHHHHHHCCCCCHH		-
33	Other	KAGAAKRKATGPPVS HHHHHHHHCCCCCHH		-
33	Methylation	KAGAAKRKATGPPVS HHHHHHHHCCCCCHH		-
35	Phosphorylation	GAAKRKATGPPVSEL HHHHHHCCCCCHHHH		-
40	Phosphorylation	KATGPPVSELITKAV HCCCCCHHHHHHHHH		-
45	Acetylation	PVSELITKAVSASKE CHHHHHHHHHHHHHH		25786129
51	Other	TKAVSASKERGGVSL HHHHHHHHHHCCCCH		-
53	Citrullination	AVSASKERGGVSLPA HHHHHHHHCCCCHHH		-
53	Citrullination	AVSASKERGGVSLPA HHHHHHHHCCCCHHH		-
63	Other	VSLPALKKALAAGGY CCHHHHHHHHHCCCC		-
74	Acetylation	AGGYDVEKNNSRIKL CCCCCCCCCCCCEEE		22902405
80	Acetylation	EKNNSRIKLGLKSLV CCCCCCEEEHHHHHH		-
84	Other	SRIKLGLKSLVSKGT CCEEEHHHHHHHCCC		-
84	Acetylation	SRIKLGLKSLVSKGT CCEEEHHHHHHHCCC		72630441
85	Phosphorylation	RIKLGLKSLVSKGTL CEEEHHHHHHHCCCE		28432305
88	Phosphorylation	LGLKSLVSKGTLVQT EHHHHHHHCCCEEEE		28432305
89	Other	GLKSLVSKGTLVQTK HHHHHHHCCCEEEEC		-
89	Acetylation	GLKSLVSKGTLVQTK HHHHHHHCCCEEEEC		56052961
91	Phosphorylation	KSLVSKGTLVQTKGT HHHHHCCCEEEECCC		25575281
96	Succinylation	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
98	Phosphorylation	TLVQTKGTGASGSFK CEEEECCCCCCCCEE		23984901
101	Phosphorylation	QTKGTGASGSFKLNK EECCCCCCCCEEECC		27097102
103	Phosphorylation	KGTGASGSFKLNKKV CCCCCCCCEEECCCC		27097102
105	Acetylation	TGASGSFKLNKKVAS CCCCCCEEECCCCCC		22902405
105	Other	TGASGSFKLNKKVAS CCCCCCEEECCCCCC		-
116	Acetylation	KVASGEAKPKAKKTG CCCCCCCCCCHHHCC		22902405
131	Phosphorylation	AAKAKKPTGATPKKP CCCCCCCCCCCCCCC		22673903
134	Phosphorylation	AKKPTGATPKKPKKT CCCCCCCCCCCCCCC		22673903
140	Acetylation	ATPKKPKKTAGAKKT CCCCCCCCCCCCCCC		22902405
145	Acetylation	PKKTAGAKKTVKKTP CCCCCCCCCCCCCCC		22902405
151	Phosphorylation	AKKTVKKTPKKAKKP CCCCCCCCCHHCCCC		-
164	Acetylation	KPAAAGVKKVTKSPK CCCHHCCCCCCCCHH		25786129
169	Phosphorylation	GVKKVTKSPKKAKAA CCCCCCCCHHHHHHH		-
184	Methylation	AKPKKATKSPARPKA HCCCCCCCCCCCCHH		-
184	Acetylation	AKPKKATKSPARPKA HCCCCCCCCCCCCHH		25786129
185	Phosphorylation	KPKKATKSPARPKAV CCCCCCCCCCCCHHH		22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H15_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
53	R	Citrullination	Citrullination at Arg-53 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H15_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of H15_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.