SRSF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRSF2_RAT
• UniProt AC: Q6PDU1
• Protein Name: Serine/arginine-rich splicing factor 2
• Gene Name: Srsf2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 221
• Subcellular Localization: Nucleus.
• Protein Description: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity)..
• Protein Sequence: MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYGRPPPD ------CCCCCCCCC	35.97	-
2	Phosphorylation	------MSYGRPPPD ------CCCCCCCCC	35.97	27097102
3	Phosphorylation	-----MSYGRPPPDV -----CCCCCCCCCC	18.82	25575281
22	Phosphorylation	SLKVDNLTYRTSPDT EEEECCEEEECCHHH	19.74	28689409
23	Phosphorylation	LKVDNLTYRTSPDTL EEECCEEEECCHHHH	18.30	21738781
25	Phosphorylation	VDNLTYRTSPDTLRR ECCEEEECCHHHHHH	33.91	21738781
26	Phosphorylation	DNLTYRTSPDTLRRV CCEEEECCHHHHHHH	16.27	23712012
29	Phosphorylation	TYRTSPDTLRRVFEK EEECCHHHHHHHHHH	26.08	25403869
36	Acetylation	TLRRVFEKYGRVGDV HHHHHHHHHCCCCCE	41.35	22902405
52	Acetylation	IPRDRYTKESRGFAF ECCHHCCCCCCCEEE	44.77	22902405
65	Acetylation	AFVRFHDKRDAEDAM EEEEECCCCCHHHHH	43.54	22902405
101	Phosphorylation	RPPDSHHSRRGPPPR CCCCCCCCCCCCCCC	20.46	27097102
140	Phosphorylation	RSRSRSRSRSRYSRS HHHHHHHHHHHHHHH	35.54	24972320
142	Phosphorylation	RSRSRSRSRYSRSKS HHHHHHHHHHHHHHH	36.50	22673903
144	Phosphorylation	RSRSRSRYSRSKSRS HHHHHHHHHHHHHHH	15.07	22673903
145	Phosphorylation	SRSRSRYSRSKSRSR HHHHHHHHHHHHHHH	29.03	22673903
147	Phosphorylation	SRSRYSRSKSRSRTR HHHHHHHHHHHHHHH	29.10	22673903
187	Phosphorylation	RSRSRSRSRSRSPPP HHHHHHCCCCCCCCC	35.54	27097102
189	Phosphorylation	RSRSRSRSRSPPPVS HHHHCCCCCCCCCCC	38.05	23712012
191	Phosphorylation	RSRSRSRSPPPVSKR HHCCCCCCCCCCCHH	42.90	23712012
196	Phosphorylation	SRSPPPVSKRESKSR CCCCCCCCHHHHCCC	31.59	27097102
204	Phosphorylation	KRESKSRSRSKSPPK HHHHCCCCCCCCCCC	48.25	-
206	Phosphorylation	ESKSRSRSKSPPKSP HHCCCCCCCCCCCCH	38.44	23712012
208	Phosphorylation	KSRSRSKSPPKSPEE CCCCCCCCCCCCHHH	47.91	23712012
212	Phosphorylation	RSKSPPKSPEEEGAV CCCCCCCCHHHCCCC	43.23	21738781
220	Phosphorylation	PEEEGAVSS------ HHHCCCCCC------	29.78	27097102
221	Phosphorylation	EEEGAVSS------- HHCCCCCC-------	37.33	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRSF2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
52	K	Acetylation	Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRSF2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SRSF2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.