TCPD_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPD_RAT
• UniProt AC: Q7TPB1
• Protein Name: T-complex protein 1 subunit delta
• Gene Name: Cct4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 539
• Subcellular Localization: Cytoplasm . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body .
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
• Protein Sequence: MPENVASRSGPPAAGPGNRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Methylation	PAAGPGNRGKGAYQD CCCCCCCCCCCCCCC	54.86	-
21	Acetylation	AGPGNRGKGAYQDRD CCCCCCCCCCCCCCC	36.81	-
36	Phosphorylation	KPAQIRFSNISAAKA CCCCEEECCHHHHHH	24.33	-
95	Phosphorylation	ARMLVELSKAQDIEA HHHHHHHHHHCCCCC	16.67	26022182
106	Phosphorylation	DIEAGDGTTSVVIIA CCCCCCCCEEEEEEE	22.19	26022182
119	Phosphorylation	IAGSLLDSCTKLLQK EEHHHHHHHHHHHHC	24.53	26022182
121	Phosphorylation	GSLLDSCTKLLQKGI HHHHHHHHHHHHCCC	28.78	26022182
184	Phosphorylation	SQYSSLLSPMSVNAV HHHHHHHCCCCHHHH	24.69	-
202	Phosphorylation	IDPATATSVDLRDIK CCHHHCCCCCHHHHH	15.92	-
236	Phosphorylation	LTQKVANSGITRVEK HCHHHHHCCCCCCHH	23.10	29779826
288	Acetylation	AYILNLVKQIKKTGC HHHHHHHHHHHHHCC	49.85	22902405
302	Acetylation	CNVLLIQKSILRDAL CCEEEEEHHHHHHHH	32.25	-
319	Acetylation	LALHFLNKMKIMVVK HHHHHHHHCCEEEEE	43.66	-
321	Acetylation	LHFLNKMKIMVVKDI HHHHHHCCEEEEECC	29.29	22902405
326	Acetylation	KMKIMVVKDIEREDI HCCEEEEECCCHHHH	41.39	-
377	Phosphorylation	SGKLFKITGCTSPGK CCCEEEEEECCCCCC	27.13	28432305
380	Phosphorylation	LFKITGCTSPGKTVT EEEEEECCCCCCEEE	39.02	28432305
381	Phosphorylation	FKITGCTSPGKTVTI EEEEECCCCCCEEEE	35.41	28432305
395	Acetylation	IVVRGSNKLVIEEAE EEECCCCCEEECHHH	45.92	22902405
444	Phosphorylation	TEYSRTLSGMESYCV HHHHHHHCCHHHHHH	35.17	22817900
448	Phosphorylation	RTLSGMESYCVRAFA HHHCCHHHHHHHHHH	18.23	22817900
449	Phosphorylation	TLSGMESYCVRAFAD HHCCHHHHHHHHHHH	5.01	-
538	Phosphorylation	KIDDVVNTR------ CHHHHCCCC------	26.58	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPD_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPD_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPD_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TCPD_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.