HNRH1_RAT - dbPTM
HNRH1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRH1_RAT
UniProt AC Q8VHV7
Protein Name Heterogeneous nuclear ribonucleoprotein H
Gene Name Hnrnph1
Organism Rattus norvegicus (Rat).
Sequence Length 449
Subcellular Localization Nucleus, nucleoplasm .
Protein Description This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity)..
Protein Sequence MMLGAEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSEEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIETGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MMLGAEGG
-------CCCCCCCC		4.52-
2Acetylation------MMLGAEGGE
------CCCCCCCCC		4.80-
21PhosphorylationKVRGLPWSCSADEVQ
EEECCCCCCCHHHHH		9.0323984901
23PhosphorylationRGLPWSCSADEVQRF
ECCCCCCCHHHHHHH		32.9927097102
54PhosphorylationYTREGRPSGEAFVEL
EEECCCCCCCEEEEE		48.1522817900
63PhosphorylationEAFVELESEDEVKLA
CEEEEECCHHHHEEE		64.0727097102
100PhosphorylationMDWVLKHTGPNSPDT
EEEEEEECCCCCCCC		53.3923712012
104PhosphorylationLKHTGPNSPDTANDG
EEECCCCCCCCCCCC		27.5623712012
107PhosphorylationTGPNSPDTANDGFVR
CCCCCCCCCCCCEEE		30.6423712012
151PhosphorylationPVDFQGRSTGEAFVQ
CCCCCCCCHHHHHHH		47.8123984901
152PhosphorylationVDFQGRSTGEAFVQF
CCCCCCCHHHHHHHH		37.3723984901
161PhosphorylationEAFVQFASQEIAEKA
HHHHHHHHHHHHHHH		29.6323984901
167AcetylationASQEIAEKALKKHKE
HHHHHHHHHHHHHHH		50.422641255
219PhosphorylationRPGAGRGYNSIGRGA
CCCCCCCCCCCCCCC		12.3621630457
221PhosphorylationGAGRGYNSIGRGAGF
CCCCCCCCCCCCCCH		20.2421630457
224MethylationRGYNSIGRGAGFERM
CCCCCCCCCCCHHHH		30.0725056663
232MethylationGAGFERMRRGAYGGG
CCCHHHHHCCCCCCC		39.8526494629
233MethylationAGFERMRRGAYGGGY
CCHHHHHCCCCCCCC		25.4212018761
246PhosphorylationGYGGYDDYNGYNDGY
CCCCCCCCCCCCCCC		13.95-
266PhosphorylationRFGRDLNYCFSGMSD
CCCCCCCCCCCCCCC		11.36-
269PhosphorylationRDLNYCFSGMSDHRY
CCCCCCCCCCCCCCC		29.9928432305
272PhosphorylationNYCFSGMSDHRYGDG
CCCCCCCCCCCCCCC		33.5228432305
306PhosphorylationRATENDIYNFFSPLN
CCCCCCCHHCCCCCC		14.5825575281
310PhosphorylationNDIYNFFSPLNPVRV
CCCHHCCCCCCCEEE		25.0827097102
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRH1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRH1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRH1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HNRH1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRH1_RAT

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Related Literatures of Post-Translational Modification

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