MCTS1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCTS1_RAT
• UniProt AC: Q4G009
• Protein Name: Malignant T-cell-amplified sequence 1
• Gene Name: Mcts1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 182
• Subcellular Localization: Cytoplasm.
• Protein Description: Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity)..
• Protein Sequence: MGKGRFDEKENVSNCIQLKTSVIKGIKNQLLEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Acetylation	QLKTSVIKGIKNQLL HHHHHHHHHHHHHHH	53.05	22902405
52	Acetylation	MPKKDPVKIVRCHEH CCCCCCCEEEECCCC	40.65	22902405
82	Phosphorylation	REGPFYPTLRLLHKY CCCCCHHHHHHHHCC	17.09	-
88	Acetylation	PTLRLLHKYPFILPH HHHHHHHCCCCCCCC	55.37	22902405
108	Phosphorylation	GAIKFVLSGANIMCP CHHHHHHCCCCEECC	30.47	23800682
119	Phosphorylation	IMCPGLTSPGAKLYP EECCCCCCCCCCCCH	26.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCTS1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCTS1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCTS1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MCTS1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.