RS6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS6_RAT
• UniProt AC: P62755
• Protein Name: 40S ribosomal protein S6
• Gene Name: Rps6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 249
• Protein Description: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA..
• Protein Sequence: MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKLNISFPATGCQ --CCCEEEECCCCCC	24.89	23984901
10	Phosphorylation	LNISFPATGCQKLIE CEEEECCCCCCEEEE	38.43	23984901
30	Acetylation	KLRTFYEKRMATEVA HHHHHHHHHHHHHHH	35.77	22902405
64	Acetylation	DKQGFPMKQGVLTHG CCCCCCCCCCEECHH	44.10	22902405
125	Phosphorylation	EKDIPGLTDTTVPRR CCCCCCCCCCCCCCC	36.90	23984901
127	Phosphorylation	DIPGLTDTTVPRRLG CCCCCCCCCCCCCCC	25.18	23984901
128	Phosphorylation	IPGLTDTTVPRRLGP CCCCCCCCCCCCCCH	31.18	23984901
137	Hydroxylation	PRRLGPKRASRIRKL CCCCCHHHHHHHHHH	40.71	-
148	Phosphorylation	IRKLFNLSKEDDVRQ HHHHHCCCCCCCHHH	34.79	27097102
149	Acetylation	RKLFNLSKEDDVRQY HHHHCCCCCCCHHHH	69.22	22902405
203	Acetylation	KQRTKKNKEEAAEYA HHHCCCCHHHHHHHH	66.85	22902405
211	Acetylation	EEAAEYAKLLAKRMK HHHHHHHHHHHHHHH	43.03	22902405
235	Phosphorylation	IAKRRRLSSLRASTS HHHHHHHHHHHHHCC	26.05	15358595
236	Phosphorylation	AKRRRLSSLRASTSK HHHHHHHHHHHHCCC	26.85	15358595
240	Phosphorylation	RLSSLRASTSKSESS HHHHHHHHCCCCHHC	27.12	23712012
241	Phosphorylation	LSSLRASTSKSESSQ HHHHHHHCCCCHHCC	38.91	27097102
242	Phosphorylation	SSLRASTSKSESSQK HHHHHHCCCCHHCCC	31.52	27097102
244	Phosphorylation	LRASTSKSESSQK-- HHHHCCCCHHCCC--	42.34	27097102
246	Phosphorylation	ASTSKSESSQK---- HHCCCCHHCCC----	45.20	27097102
247	Phosphorylation	STSKSESSQK----- HCCCCHHCCC-----	37.63	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
235	S	Phosphorylation	Kinase	RPS6KA1	Q63531	Uniprot
235	S	Phosphorylation	Kinase	DAPK1	-	Uniprot
235	S	Phosphorylation	Kinase	RPS6KA3	-	Uniprot
235	S	Phosphorylation	Kinase	DAPK-FAMILY	-	GPS
235	S	Phosphorylation	Kinase	PASK	O88506	Uniprot
235	S	Phosphorylation	Kinase	RPS6KB1	P67999	GPS
235	S	Phosphorylation	Kinase	AKT1	P47196	PSP
235	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
235	S	Phosphorylation	Kinase	AKT2	P47197	PSP
236	S	Phosphorylation	Kinase	PKACA	P17612	PSP
236	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
236	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
236	S	Phosphorylation	Kinase	RPS6KB1	P67999	GPS
236	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
236	S	Phosphorylation	Kinase	AKT2	P47197	PSP
236	S	Phosphorylation	Kinase	AKT1	P47196	PSP
240	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
240	S	Phosphorylation	Kinase	RPS6KB1	P67999	GPS
244	S	Phosphorylation	Kinase	RPS6KB1	P67999	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
137	R	Hydroxylation	Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.	-
235	S	Phosphorylation	Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.	-
236	S	Phosphorylation	Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.	22673903

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS6_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RS6_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.