ENPL_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENPL_RAT
• UniProt AC: Q66HD0
• Protein Name: Endoplasmin {ECO:0000250|UniProtKB:P08113}
• Gene Name: Hsp90b1 {ECO:0000250|UniProtKB:P08113}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 804
• Subcellular Localization: Endoplasmic reticulum lumen . Melanosome .
• Protein Description: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity)..
• Protein Sequence: MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEADDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTTEDTTDDSEQDEEETDAGAEEEEEEQETEKEPTEKDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	AIQLDGLNASQIREL HHHCCCCCHHHHHHH	42.97	-
64	Phosphorylation	QLDGLNASQIRELRE HCCCCCHHHHHHHHH	25.68	27097102
75	Acetylation	ELREKSEKFAFQAEV HHHHHHHHHHHHHHH	49.43	25786129
95	Acetylation	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	22902405
97	Acetylation	INSLYKNKEIFLREL HHHHHCCHHHHHHHH	48.30	72623277
106	Phosphorylation	IFLRELISNASDALD HHHHHHHHCCHHHHH	38.68	23984901
107	N-linked_Glycosylation	FLRELISNASDALDK HHHHHHHCCHHHHHH	36.15	-
109	Phosphorylation	RELISNASDALDKIR HHHHHCCHHHHHHHE	27.89	23984901
114	Acetylation	NASDALDKIRLISLT CCHHHHHHHEEEEEC	30.49	72585793
142	Acetylation	KIKCDREKNLLHVTD EEEECCCCCEEEEEC	54.51	22902405
171	Phosphorylation	GTIAKSGTSEFLNKM HHHHHHCHHHHHHHH	31.97	23984901
172	Phosphorylation	TIAKSGTSEFLNKMT HHHHHCHHHHHHHHH	29.85	28432305
200	Phosphorylation	GQFGVGFYSAFLVAD HHHCCHHHHHHHEEC	7.99	28689409
213	Phosphorylation	ADKVIVTSKHNNDTQ ECEEEEEECCCCCCC	22.48	28689409
217	N-linked_Glycosylation	IVTSKHNNDTQHIWE EEEECCCCCCCCEEE	54.12	-
265	Acetylation	YLELDTIKNLVRKYS CCCHHHHHHHHHHHH	46.45	22902405
271	Phosphorylation	IKNLVRKYSQFINFP HHHHHHHHHHHHCCC	9.35	23984901
272	Phosphorylation	KNLVRKYSQFINFPI HHHHHHHHHHHCCCE	22.96	23984901
340	Succinylation	WELMNDIKPIWQRPS HHHHCCCCCHHCCCC	33.06	26843850
356	Acetylation	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	22902405
392	Phosphorylation	SILFVPTSAPRGLFD EEEEEECCCCCCCCH	30.15	28689409
403	Phosphorylation	GLFDEYGSKKSDYIK CCCHHCCCCHHHHHH	35.69	22673903
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
404	Acetylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	22902405
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
410	Acetylation	SKKSDYIKLYVRRVF CCHHHHHHEEEEEEE	27.77	22902405
439	Phosphorylation	FVKGVVDSDDLPLNV HHCCCCCCCCCCCCC	22.78	25575281
445	N-linked_Glycosylation	DSDDLPLNVSRETLQ CCCCCCCCCCHHHHH	27.98	-
447	Phosphorylation	DDLPLNVSRETLQQH CCCCCCCCHHHHHHH	24.27	27097102
450	Phosphorylation	PLNVSRETLQQHKLL CCCCCHHHHHHHHHH	28.85	25575281
455	Acetylation	RETLQQHKLLKVIRK HHHHHHHHHHHHHHH	51.69	22902405
473	Acetylation	RKTLDMIKKIADEKY HHHHHHHHHHHHHHC	31.33	22902405
479	Acetylation	IKKIADEKYNDTFWK HHHHHHHHCCHHHHH	50.31	22902405
481	N-linked_Glycosylation	KIADEKYNDTFWKEF HHHHHHCCHHHHHHH	53.57	-
501	Phosphorylation	LGVIEDHSNRTRLAK EEEEECCCCHHHHHH	40.09	22673903
502	N-linked_Glycosylation	GVIEDHSNRTRLAKL EEEECCCCHHHHHHH	46.02	-
504	Phosphorylation	IEDHSNRTRLAKLLR EECCCCHHHHHHHHH	33.99	25575281
514	Phosphorylation	AKLLRFQSSHHSTDI HHHHHHHCCCCCCCC	29.00	27097102
515	Phosphorylation	KLLRFQSSHHSTDIT HHHHHHCCCCCCCCC	17.90	27097102
518	Phosphorylation	RFQSSHHSTDITSLD HHHCCCCCCCCCHHH	23.50	27097102
519	Phosphorylation	FQSSHHSTDITSLDQ HHCCCCCCCCCHHHH	27.36	27097102
522	Phosphorylation	SHHSTDITSLDQYVE CCCCCCCCHHHHHHH	26.50	27097102
523	Phosphorylation	HHSTDITSLDQYVER CCCCCCCHHHHHHHH	30.22	27097102
534	Acetylation	YVERMKEKQDKIYFM HHHHHHHHCCCEEEE	59.27	22902405
537	Acetylation	RMKEKQDKIYFMAGS HHHHHCCCEEEEECC	36.49	22902405
547	Succinylation	FMAGSSRKEAESSPF EEECCCCCHHHCCHH	64.32	26843850
597	Acetylation	NVAKEGVKFDESEKS HHHHHCCCCCHHHHH	58.93	22902405
604	Phosphorylation	KFDESEKSKESREAT CCCHHHHHHHHHHHH	37.29	28432305
607	Phosphorylation	ESEKSKESREATEKE HHHHHHHHHHHHHHH	38.87	28432305
613	Acetylation	ESREATEKEFEPLLN HHHHHHHHHHHHHHH	64.45	22902405
628	Acetylation	WMKDKALKDKIEKAV HHHHHHHHHHHHHHH	62.93	22902405
630	Acetylation	KDKALKDKIEKAVVS HHHHHHHHHHHHHHH	51.70	22902405
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	-
633	Acetylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	22902405
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	-
671	Acetylation	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	22902405
674	Phosphorylation	YQTGKDISTNYYASQ HHHCCCCCCCCCCCC	22.27	27097102
675	Phosphorylation	QTGKDISTNYYASQK HHCCCCCCCCCCCCC	27.81	27097102
677	Phosphorylation	GKDISTNYYASQKKT CCCCCCCCCCCCCCE	10.66	25575281
678	Phosphorylation	KDISTNYYASQKKTF CCCCCCCCCCCCCEE	11.22	25575281
680	Phosphorylation	ISTNYYASQKKTFEI CCCCCCCCCCCEEEC	26.81	25575281
682	Acetylation	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	22902405
683	Succinylation	NYYASQKKTFEINPR CCCCCCCCEEECCCC	51.30	26843850

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENPL_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENPL_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENPL_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.