ACTC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTC_RAT
• UniProt AC: P68035
• Protein Name: Actin, alpha cardiac muscle 1
• Gene Name: Actc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
• Protein Sequence: MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCDDEETTA ------CCCHHHCEE	10.18	-
3	Acetylation	-----MCDDEETTAL -----CCCHHHCEEE	66.12	-
35	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	5130775
35	O-linked_Glycosylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	18988896
46	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
49	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
52	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	15605073
54	O-linked_Glycosylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	18988896
54	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	25403869
55	Phosphorylation	GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC	20.70	4817623
62	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	29779826
62	O-linked_Glycosylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	18988896
63	Acetylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	15603155
68	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	28826663
70	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	26302492
71	Phosphorylation	RGILTLKYPIEHGII CCEEEEECEECCCCC	16.74	22673903
75	Methylation	TLKYPIEHGIITNWD EEECEECCCCCCCHH	33.21	-
79	Phosphorylation	PIEHGIITNWDDMEK EECCCCCCCHHHHHH	28.47	36748793
86	Methylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
86	Acetylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	26302492
91	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	9548383
93	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	174691
115	Acetylation	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	30595931
128	Phosphorylation	MTQIMFETFNVPAMY HHHHHHHHCCHHHHH	14.83	21630457
135	Phosphorylation	TFNVPAMYVAIQAVL HCCHHHHHHHHHHHH	6.71	21630457
150	Phosphorylation	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	22673903
151	Phosphorylation	LYASGRTTGIVLDSG HHHCCCCEEEEEECC	24.45	22673903
157	O-linked_Glycosylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	18988896
157	Phosphorylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	-
168	Phosphorylation	VTHNVPIYEGYALPH CCCCCCEECCCCHHH	9.38	3840507
171	Phosphorylation	NVPIYEGYALPHAIM CCCEECCCCHHHHHH	7.94	15569651
188	Phosphorylation	DLAGRDLTDYLMKIL HCCCCCHHHHHHHHH	27.21	22673903
190	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	18876225
193	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646663
200	Phosphorylation	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	174795
201	O-linked_Glycosylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	18988896
201	Phosphorylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	5130783
204	Phosphorylation	ERGYSFVTTAEREIV HCCCCCEEHHCHHHH	20.48	22673903
205	Phosphorylation	RGYSFVTTAEREIVR CCCCCEEHHCHHHHH	22.63	9548407
215	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	15604253
220	Phosphorylation	DIKEKLCYVALDFEN HHHHHHCEEEEECCH	10.13	174797
234	O-linked_Glycosylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	18988896
234	Phosphorylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	28551015
235	Phosphorylation	EMATAASSSSLEKSY HHHHHCCCCCCCHHE	21.15	28551015
236	Phosphorylation	MATAASSSSLEKSYE HHHHCCCCCCCHHEE	36.13	28551015
237	Phosphorylation	ATAASSSSLEKSYEL HHHCCCCCCCHHEEC	42.36	28551015
241	O-linked_Glycosylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	18988896
241	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	28689409
242	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	22108457
251	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	46314633
293	Acetylation	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	54350343
296	Phosphorylation	IDIRKDLYANNVLSG CEECHHHHHCCCCCC	19.88	20563991
308	Phosphorylation	LSGGTTMYPGIADRM CCCCCCCCCCHHHHH	9.01	11887203
317	Acetylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	51083205
320	Phosphorylation	DRMQKEITALAPSTM HHHHHHHHHHCCCCE	19.40	3972893
325	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	9423901
325	O-linked_Glycosylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	18988896
326	Phosphorylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	27097102
326	O-linked_Glycosylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	18988896
328	Acetylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	15603731
330	Acetylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	15626295
340	Phosphorylation	APPERKYSVWIGGSI CCCCCCEEEEECHHH	17.63	30417516
364	Phosphorylation	MWISKQEYDEAGPSI HHHCHHHHCCCCCCC	19.31	20312689
370	Phosphorylation	EYDEAGPSIVHRKCF HHCCCCCCCCCCCCC	36.00	22673903
370	O-linked_Glycosylation	EYDEAGPSIVHRKCF HHCCCCCCCCCCCCC	36.00	18988896

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTC_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
46	M	Oxidation	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	-
49	M	Oxidation	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	-
75	H	Methylation	Methylated at His-75 by SETD3.	-
86	K	Methylation	Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.