dbPTM

HAP28_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HAP28_RAT
UniProt AC	Q62785
Protein Name	28 kDa heat- and acid-stable phosphoprotein
Gene Name	Pdap1
Organism	Rattus norvegicus (Rat).
Sequence Length	181
Subcellular Localization
Protein Description
Protein Sequence	MPKGGRKGGHKGRVRQYTSPEEIDAQLQAEKQKANEEDEQEEGGDGASGDPKKEKKSLDSDESEDEDDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	HKGRVRQYTSPEEID CCCCCCCCCCHHHHH	9.91	27097102
18	Phosphorylation	KGRVRQYTSPEEIDA CCCCCCCCCHHHHHH	29.48	27097102
19	Phosphorylation	GRVRQYTSPEEIDAQ CCCCCCCCHHHHHHH	25.94	27097102
48	Phosphorylation	EEGGDGASGDPKKEK HCCCCCCCCCCHHHH	49.62	29779826
57	Phosphorylation	DPKKEKKSLDSDESE CCHHHHCCCCCCCCC	48.77	23712012
60	Phosphorylation	KEKKSLDSDESEDED HHHCCCCCCCCCCCC	48.87	19700791
63	Phosphorylation	KSLDSDESEDEDDDY CCCCCCCCCCCCCHH	56.17	19700791
70	Phosphorylation	SEDEDDDYQQKRKGV CCCCCCHHHHHHHCC	21.60	25575281
75	Acetylation	DDYQQKRKGVEGLID CHHHHHHHCCCCCCC	74.48	22902405
105	Acetylation	QLDLDGPKELSRRER ECCCCCHHHHCHHHH	76.46	22902405
117	Acetylation	REREEIEKQKAKERY HHHHHHHHHHHHHHH	63.86	22902405
126	Acetylation	KAKERYMKMHLAGKT HHHHHHHHHHHCCCH	17.77	22902405
126	Methylation	KAKERYMKMHLAGKT HHHHHHHHHHHCCCH	17.77	-
132	Acetylation	MKMHLAGKTEQAKAD HHHHHCCCHHHHHHH	43.19	22902405
137	Acetylation	AGKTEQAKADLARLA CCCHHHHHHHHHHHH	41.97	22902405
164	Acetylation	KEEERKAKDDATLSG HHHHHHHHHHCCCCC	60.21	22902405
172	Acetylation	DDATLSGKRMQSLSL HHCCCCCHHHHHHCC	41.12	22902405
176	Phosphorylation	LSGKRMQSLSLNK-- CCCHHHHHHCCCC--	15.58	27097102
178	Phosphorylation	GKRMQSLSLNK---- CHHHHHHCCCC----	34.83	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HAP28_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HAP28_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HAP28_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HAP28_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HAP28_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-63, AND MASSSPECTROMETRY.	16641100 [Abstract]
"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."; Moser K., White F.M.; J. Proteome Res. 5:98-104(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-63, AND MASSSPECTROMETRY.	16396499 [Abstract]