dbPTM

PPIB_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPIB_RAT
UniProt AC	P24368
Protein Name	Peptidyl-prolyl cis-trans isomerase B
Gene Name	Ppib
Organism	Rattus norvegicus (Rat).
Sequence Length	216
Subcellular Localization	Endoplasmic reticulum lumen . Melanosome .
Protein Description	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding..
Protein Sequence	MLRLSERNMKVLFAAALIVGSVVFLLLPGPSVANDKKKGPKVTVKVYFDFQIGDEPVGRVTFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTSWLDGKHVVFGKVLEGMDVVRKVENTKTDSRDKPLKDVIIVDCGKIEVEKPFAIAKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Acetylation	VTFGLFGKTVPKTVD EEEEECCCCCCCCHH	38.73	22902405
71	Acetylation	LFGKTVPKTVDNFVA ECCCCCCCCHHCEEH	57.77	22902405
84	Succinylation	VALATGEKGFGYKNS EHHHCCCCCCCCCCC	61.97	-
91	Phosphorylation	KGFGYKNSKFHRVIK CCCCCCCCCHHHEEE	32.33	21373199
116	Acetylation	RGDGTGGKSIYGERF CCCCCCCCCCCCCCC	34.72	22902405
165	Acetylation	KTSWLDGKHVVFGKV EEEECCCCCEEEEEE	32.66	22902405
202	S-nitrosylation	KDVIIVDCGKIEVEK CEEEEEECCCEEEEC	4.07	-
209	Acetylation	CGKIEVEKPFAIAKE CCCEEEECCCEECCC	51.08	-
209	Succinylation	CGKIEVEKPFAIAKE CCCEEEECCCEECCC	51.08	-
209	Succinylation	CGKIEVEKPFAIAKE CCCEEEECCCEECCC	51.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PPIB_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PPIB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPIB_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PPIB_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PPIB_RAT

Related Literatures of Post-Translational Modification