KLC1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLC1_RAT
• UniProt AC: P37285
• Protein Name: Kinesin light chain 1
• Gene Name: Klc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 560
• Subcellular Localization: Cell projection, growth cone . Cytoplasmic vesicle . Cytoplasm, cytoskeleton .
• Protein Description: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity..
• Protein Sequence: MHDNMSTMVYMKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAEVLNDPENVEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGMRKMKLGLVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Ubiquitination	LETLKCLKKDDESNL HHHHHHHCCCCCCCH	64.72	-
162	Phosphorylation	KKYDDDISPSEDKDS HHCCCCCCCCCCCCC	29.39	30411139
164	Phosphorylation	YDDDISPSEDKDSDS CCCCCCCCCCCCCCC	52.19	30240740
389	Phosphorylation	KTKNNLASCYLKQGK HHHHCHHHHHHHCCC	13.37	23984901
391	Phosphorylation	KNNLASCYLKQGKFK HHCHHHHHHHCCCHH	17.90	23984901
418	Phosphorylation	AHEREFGSVDDENKP HHHHHCCCCCCCCCC	27.91	27097102
444	Phosphorylation	KGKQKDGSSFGEYGG CCCCCCCCCCCCCCC	32.40	28432305
445	Phosphorylation	GKQKDGSSFGEYGGW CCCCCCCCCCCCCCC	42.68	28432305
449	Phosphorylation	DGSSFGEYGGWYKAC CCCCCCCCCCCEEEC	22.71	27097102
460	Phosphorylation	YKACKVDSPTVTTTL EEECCCCCCCCHHHH	26.00	27097102
462	Phosphorylation	ACKVDSPTVTTTLKN ECCCCCCCCHHHHHH	34.14	28551015
464	Phosphorylation	KVDSPTVTTTLKNLG CCCCCCCHHHHHHHH	19.28	28551015
465	Phosphorylation	VDSPTVTTTLKNLGA CCCCCCHHHHHHHHH	26.29	28551015
466	Phosphorylation	DSPTVTTTLKNLGAL CCCCCHHHHHHHHHH	26.77	28551015
521	Phosphorylation	ENVEKRRSRESLNVD HHHHHHHHHHHCCCC	44.42	23712012
524	Phosphorylation	EKRRSRESLNVDVVK HHHHHHHHCCCCEEE	24.92	23712012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
460	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
460	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLC1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLC1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAU_HUMAN	MAPT	physical	16176937

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.