VGLU1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VGLU1_RAT
• UniProt AC: Q62634
• Protein Name: Vesicular glutamate transporter 1
• Gene Name: Slc17a7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 560
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate..
• Protein Sequence: MEFRQEEFRKLAGRALGRLHRLLEKRQEGAETLELSADGRPVTTHTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDESEMEDEVEPPGAPPAPPPSYGATHSTVQPPRPPPPVRDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	GAETLELSADGRPVT CCCEEEECCCCCCCC	18.22	27115346
169	Phosphorylation	PSAARVHYGCVIFVR CCCHHHHCCHHHHHH	14.90	-
186	Phosphorylation	QGLVEGVTYPACHGI HHHHCCCCCHHHCCH	34.34	-
187	Phosphorylation	GLVEGVTYPACHGIW HHHCCCCCHHHCCHH	6.09	-
272	Ubiquitination	SISEEERKYIEDAIG CCCHHHHHHHHHHHH	54.59	-
283	Ubiquitination	DAIGESAKLMNPVTK HHHHHHHHHCCCCCC	58.51	-
504	Phosphorylation	WAEPEEMSEEKCGFV CCCHHHCCHHHCCCC	45.97	16987242
519	Phosphorylation	GHDQLAGSDESEMED CCHHCCCCCHHHCCC	32.37	-
522	Phosphorylation	QLAGSDESEMEDEVE HCCCCCHHHCCCCCC	47.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VGLU1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VGLU1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VGLU1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VGLU1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.