RTCB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTCB_RAT
• UniProt AC: Q6AYT3
• Protein Name: tRNA-splicing ligase RtcB homolog {ECO:0000255|HAMAP-Rule:MF_03144}
• Gene Name: Rtcb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 505
• Subcellular Localization: Nucleus. Cytoplasm . Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low..
• Protein Description: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs..
• Protein Sequence: MSRNYNDELQFLDKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSPRAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRNYNDEL ------CCCCCHHHH	29.27	23984901
14	Acetylation	DELQFLDKINKNCWR HHHHHHHHHHHCCCC	50.77	22902405
157	Phosphorylation	HIPVGVGSKGVIPMN CCCCCCCCCCCCCCC	24.67	23984901
208	Phosphorylation	QADPNKVSPRAKKRG CCCCCCCCHHHHHCC	15.41	23984901
244	Acetylation	IFNEYAAKKMGIDHK HHHHHHHHHCCCCCC	34.81	26302492
245	Acetylation	FNEYAAKKMGIDHKG HHHHHHHHCCCCCCC	37.32	26302492
251	Acetylation	KKMGIDHKGQVCVMI HHCCCCCCCCEEEEE	47.49	26302492
285	Acetylation	EKAMKRDKIIVNDRQ HHHHHCCCEEECCHH	38.06	22902405
300	Phosphorylation	LACARIASPEGQDYL HHHHHHCCCCCHHHH	22.55	23984901
366	Ubiquitination	EQHVVDGKERTLLVH EEEEECCCEEEEEEE	39.29	-
465	Ubiquitination	AIRVASPKLVMEEAP EEEECCCHHHHCCCC	51.74	-
496	Acetylation	GISKKAIKLRPIAVI CCCHHHEECEEEEEE	43.22	25786129

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTCB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTCB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTCB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RTCB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.