dbPTM

SEPT7_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT7_RAT
UniProt AC	Q9WVC0
Protein Name	Septin-7
Gene Name	7-Sep
Organism	Rattus norvegicus (Rat).
Sequence Length	436
Subcellular Localization	Cytoplasm . Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum . Distributed throughout the cytoplasm in prometaphase cells. Ass
Protein Description	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)..
Protein Sequence	MSVSARSAAAEERSVNCSTMAQPKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQGHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKNKKKGKIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVSARSAA ------CCHHHHHHH	25.44	-
29	Phosphorylation	QPKNLEGYVGFANLP CCCCCCCCCEECCCC	6.50	-
72	Phosphorylation	LINSLFLTDLYSPEY HHHHHHCCCCCCCCC	19.34	23984901
75	Phosphorylation	SLFLTDLYSPEYPGP HHHCCCCCCCCCCCC	25.62	25403869
76	Phosphorylation	LFLTDLYSPEYPGPS HHCCCCCCCCCCCCC	20.67	25403869
79	Phosphorylation	TDLYSPEYPGPSHRI CCCCCCCCCCCCCCC	19.51	23984901
83	Phosphorylation	SPEYPGPSHRIKKTV CCCCCCCCCCCEEEE	31.17	23984901
96	Acetylation	TVQVEQSKVLIKEGG EEEEECCEEEEEECC	40.53	22902405
185	Acetylation	FMKRLHEKVNIIPLI HHHHHHHHHCCHHHH	29.81	22902405
207	Acetylation	PEECQQFKKQIMKEI HHHHHHHHHHHHHHH	39.16	22902405
220	Acetylation	EIQGHKIKIYEFPET HHCCCEEEEEECCCC	44.00	72603029
222	Phosphorylation	QGHKIKIYEFPETDD CCCEEEEEECCCCCC	13.40	-
227	Phosphorylation	KIYEFPETDDEEENK EEEECCCCCCHHHHH	49.33	27097102
234	Acetylation	TDDEEENKLVKKIKD CCCHHHHHHHHHHHH	58.92	22902405
308	Phosphorylation	NNVHYENYRSRKLAA CCCCCCCHHHCCEEE	9.68	-
318	Phosphorylation	RKLAAVTYNGVDNNK CCEEEEEECCCCCCC	11.88	-
331	Phosphorylation	NKNKGQLTKSPLAQM CCCCCCCCCCHHHHC	22.91	28432305
333	Phosphorylation	NKGQLTKSPLAQMEE CCCCCCCCHHHHCHH	21.65	27097102
370	Acetylation	KVKEKVQKLKDSEAE HHHHHHHHHCHHHHH	61.56	72605703
372	Acetylation	KEKVQKLKDSEAELQ HHHHHHHCHHHHHHH	67.26	72594123
394	Ubiquitination	KNLEAQHKELEEKRR HHHHHHHHHHHHHHH	52.49	-
394	Acetylation	KNLEAQHKELEEKRR HHHHHHHHHHHHHHH	52.49	72587939
407	Acetylation	RRQFEEEKANWEAQQ HHHHHHHHHHHHHHH	50.75	72612073
422	Phosphorylation	RILEQQNSSRTLEKN HHHHHHHHHHHHHHH	19.50	27097102
423	Phosphorylation	ILEQQNSSRTLEKNK HHHHHHHHHHHHHHH	36.51	27097102
425	Phosphorylation	EQQNSSRTLEKNKKK HHHHHHHHHHHHHHC	41.01	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEPT7_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEPT7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT7_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SEPT7_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT7_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-425, AND MASSSPECTROMETRY.	16641100 [Abstract]