UniProt ID | H14_RAT | |
---|---|---|
UniProt AC | P15865 | |
Protein Name | Histone H1.4 | |
Gene Name | Hist1h1e | |
Organism | Rattus norvegicus (Rat). | |
Sequence Length | 219 | |
Subcellular Localization | Nucleus. Chromosome. Mainly localizes in euchromatin.. | |
Protein Description | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).. | |
Protein Sequence | MSETAPAAPAAPAPAEKTPIKKKARKAAGGAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGTATPKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKARAVKPKAAKPKTSKPKAAKPKKTAAKKK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MSETAPAAP ------CCCCCCCCC | 23589303 | ||
2 | Acetylation | ------MSETAPAAP ------CCCCCCCCC | - | ||
4 | Phosphorylation | ----MSETAPAAPAA ----CCCCCCCCCCC | 27097102 | ||
17 | Acetylation | AAPAPAEKTPIKKKA CCCCCCCCCCCHHHH | 25786129 | ||
18 | Phosphorylation | APAPAEKTPIKKKAR CCCCCCCCCCHHHHH | 23589303 | ||
21 | Acetylation | PAEKTPIKKKARKAA CCCCCCCHHHHHHHH | 22902405 | ||
26 | Methylation | PIKKKARKAAGGAKR CCHHHHHHHHCCCCC | - | ||
26 | Acetylation | PIKKKARKAAGGAKR CCHHHHHHHHCCCCC | - | ||
34 | Other | AAGGAKRKASGPPVS HHCCCCCCCCCCCHH | - | ||
34 | Succinylation | AAGGAKRKASGPPVS HHCCCCCCCCCCCHH | - | ||
34 | Succinylation | AAGGAKRKASGPPVS HHCCCCCCCCCCCHH | - | ||
34 | Methylation | AAGGAKRKASGPPVS HHCCCCCCCCCCCHH | - | ||
36 | Phosphorylation | GGAKRKASGPPVSEL CCCCCCCCCCCHHHH | 23712012 | ||
41 | Phosphorylation | KASGPPVSELITKAV CCCCCCHHHHHHHHH | 17683130 | ||
45 | Phosphorylation | PPVSELITKAVAASK CCHHHHHHHHHHHHH | 22673903 | ||
46 | Acetylation | PVSELITKAVAASKE CHHHHHHHHHHHHHH | 25786129 | ||
52 | Acetylation | TKAVAASKERSGVSL HHHHHHHHHCCCCCH | 22902405 | ||
52 | Other | TKAVAASKERSGVSL HHHHHHHHHCCCCCH | - | ||
54 | Citrullination | AVAASKERSGVSLAA HHHHHHHCCCCCHHH | - | ||
54 | Citrullination | AVAASKERSGVSLAA HHHHHHHCCCCCHHH | - | ||
55 | Phosphorylation | VAASKERSGVSLAAL HHHHHHCCCCCHHHH | 27097102 | ||
58 | Phosphorylation | SKERSGVSLAALKKA HHHCCCCCHHHHHHH | 28432305 | ||
63 | Acetylation | GVSLAALKKALAAAG CCCHHHHHHHHHHCC | 165047 | ||
64 | Other | VSLAALKKALAAAGY CCHHHHHHHHHHCCC | - | ||
75 | Ubiquitination | AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC | - | ||
75 | Acetylation | AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC | 165049 | ||
78 | Phosphorylation | YDVEKNNSRIKLGLK CCCHHCCCCCCCCHH | 23800682 | ||
81 | Acetylation | EKNNSRIKLGLKSLV HHCCCCCCCCHHHHH | 22902405 | ||
85 | Other | SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC | - | ||
85 | Acetylation | SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC | 25786129 | ||
86 | Phosphorylation | RIKLGLKSLVSKGTL CCCCCHHHHHHCCCE | 28432305 | ||
89 | Phosphorylation | LGLKSLVSKGTLVQT CCHHHHHHCCCEEEE | 28432305 | ||
90 | Other | GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC | - | ||
90 | Acetylation | GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC | 25786129 | ||
92 | Phosphorylation | KSLVSKGTLVQTKGT HHHHHCCCEEEECCC | 25575281 | ||
97 | Succinylation | KGTLVQTKGTGASGS CCCEEEECCCCCCCC | - | ||
99 | Phosphorylation | TLVQTKGTGASGSFK CEEEECCCCCCCCEE | 23984901 | ||
102 | Phosphorylation | QTKGTGASGSFKLNK EECCCCCCCCEECCC | 27097102 | ||
104 | Phosphorylation | KGTGASGSFKLNKKA CCCCCCCCEECCCCC | 27097102 | ||
106 | Other | TGASGSFKLNKKAAS CCCCCCEECCCCCCC | - | ||
106 | Acetylation | TGASGSFKLNKKAAS CCCCCCEECCCCCCC | 25786129 | ||
117 | Acetylation | KAASGEAKPKAKKAG CCCCCCCCHHHHHHC | 22902405 | ||
136 | Acetylation | KKPAGAAKKPKKATG CCCCCCCCCCCCCCC | 25786129 | ||
146 | Phosphorylation | KKATGTATPKKSTKK CCCCCCCCCCCCCCC | 29779826 | ||
150 | ADP-ribosylation | GTATPKKSTKKTPKK CCCCCCCCCCCCCCC | - | ||
154 | Phosphorylation | PKKSTKKTPKKAKKP CCCCCCCCCCCCCCH | - | ||
160 | Acetylation | KTPKKAKKPAAAAGA CCCCCCCCHHHHHCH | 22902405 | ||
168 | Acetylation | PAAAAGAKKAKSPKK HHHHHCHHHCCCHHH | 22902405 | ||
172 | Phosphorylation | AGAKKAKSPKKAKAT HCHHHCCCHHHHHHH | - | ||
186 | Methylation | TKAKKAPKSPAKARA HHCCCCCCCHHHHHH | - | ||
187 | Phosphorylation | KAKKAPKSPAKARAV HCCCCCCCHHHHHHC | 21630457 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of H14_RAT !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
26 | K | Acetylation |
| - |
26 | K | Acetylation |
| - |
54 | R | Citrullination |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of H14_RAT !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of H14_RAT !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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