H14_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H14_RAT
• UniProt AC: P15865
• Protein Name: Histone H1.4
• Gene Name: Hist1h1e
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 219
• Subcellular Localization: Nucleus. Chromosome. Mainly localizes in euchromatin..
• Protein Description: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)..
• Protein Sequence: MSETAPAAPAAPAPAEKTPIKKKARKAAGGAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGTATPKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKARAVKPKAAKPKTSKPKAAKPKKTAAKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSETAPAAP ------CCCCCCCCC		23589303
2	Acetylation	------MSETAPAAP ------CCCCCCCCC		-
4	Phosphorylation	----MSETAPAAPAA ----CCCCCCCCCCC		27097102
17	Acetylation	AAPAPAEKTPIKKKA CCCCCCCCCCCHHHH		25786129
18	Phosphorylation	APAPAEKTPIKKKAR CCCCCCCCCCHHHHH		23589303
21	Acetylation	PAEKTPIKKKARKAA CCCCCCCHHHHHHHH		22902405
26	Methylation	PIKKKARKAAGGAKR CCHHHHHHHHCCCCC		-
26	Acetylation	PIKKKARKAAGGAKR CCHHHHHHHHCCCCC		-
34	Other	AAGGAKRKASGPPVS HHCCCCCCCCCCCHH		-
34	Succinylation	AAGGAKRKASGPPVS HHCCCCCCCCCCCHH		-
34	Succinylation	AAGGAKRKASGPPVS HHCCCCCCCCCCCHH		-
34	Methylation	AAGGAKRKASGPPVS HHCCCCCCCCCCCHH		-
36	Phosphorylation	GGAKRKASGPPVSEL CCCCCCCCCCCHHHH		23712012
41	Phosphorylation	KASGPPVSELITKAV CCCCCCHHHHHHHHH		17683130
45	Phosphorylation	PPVSELITKAVAASK CCHHHHHHHHHHHHH		22673903
46	Acetylation	PVSELITKAVAASKE CHHHHHHHHHHHHHH		25786129
52	Acetylation	TKAVAASKERSGVSL HHHHHHHHHCCCCCH		22902405
52	Other	TKAVAASKERSGVSL HHHHHHHHHCCCCCH		-
54	Citrullination	AVAASKERSGVSLAA HHHHHHHCCCCCHHH		-
54	Citrullination	AVAASKERSGVSLAA HHHHHHHCCCCCHHH		-
55	Phosphorylation	VAASKERSGVSLAAL HHHHHHCCCCCHHHH		27097102
58	Phosphorylation	SKERSGVSLAALKKA HHHCCCCCHHHHHHH		28432305
63	Acetylation	GVSLAALKKALAAAG CCCHHHHHHHHHHCC		165047
64	Other	VSLAALKKALAAAGY CCHHHHHHHHHHCCC		-
75	Ubiquitination	AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC		-
75	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC		165049
78	Phosphorylation	YDVEKNNSRIKLGLK CCCHHCCCCCCCCHH		23800682
81	Acetylation	EKNNSRIKLGLKSLV HHCCCCCCCCHHHHH		22902405
85	Other	SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC		-
85	Acetylation	SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC		25786129
86	Phosphorylation	RIKLGLKSLVSKGTL CCCCCHHHHHHCCCE		28432305
89	Phosphorylation	LGLKSLVSKGTLVQT CCHHHHHHCCCEEEE		28432305
90	Other	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		-
90	Acetylation	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		25786129
92	Phosphorylation	KSLVSKGTLVQTKGT HHHHHCCCEEEECCC		25575281
97	Succinylation	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
99	Phosphorylation	TLVQTKGTGASGSFK CEEEECCCCCCCCEE		23984901
102	Phosphorylation	QTKGTGASGSFKLNK EECCCCCCCCEECCC		27097102
104	Phosphorylation	KGTGASGSFKLNKKA CCCCCCCCEECCCCC		27097102
106	Other	TGASGSFKLNKKAAS CCCCCCEECCCCCCC		-
106	Acetylation	TGASGSFKLNKKAAS CCCCCCEECCCCCCC		25786129
117	Acetylation	KAASGEAKPKAKKAG CCCCCCCCHHHHHHC		22902405
136	Acetylation	KKPAGAAKKPKKATG CCCCCCCCCCCCCCC		25786129
146	Phosphorylation	KKATGTATPKKSTKK CCCCCCCCCCCCCCC		29779826
150	ADP-ribosylation	GTATPKKSTKKTPKK CCCCCCCCCCCCCCC		-
154	Phosphorylation	PKKSTKKTPKKAKKP CCCCCCCCCCCCCCH		-
160	Acetylation	KTPKKAKKPAAAAGA CCCCCCCCHHHHHCH		22902405
168	Acetylation	PAAAAGAKKAKSPKK HHHHHCHHHCCCHHH		22902405
172	Phosphorylation	AGAKKAKSPKKAKAT HCHHHCCCHHHHHHH		-
186	Methylation	TKAKKAPKSPAKARA HHCCCCCCCHHHHHH		-
187	Phosphorylation	KAKKAPKSPAKARAV HCCCCCCCHHHHHHC		21630457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H14_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
26	K	Acetylation	Acetylated at Lys-26.	-
26	K	Acetylation	Deacetylated at Lys-26 by SIRT1.	-
54	R	Citrullination	Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H14_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of H14_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.