H14_RAT - dbPTM
H14_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID H14_RAT
UniProt AC P15865
Protein Name Histone H1.4
Gene Name Hist1h1e
Organism Rattus norvegicus (Rat).
Sequence Length 219
Subcellular Localization Nucleus. Chromosome. Mainly localizes in euchromatin..
Protein Description Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)..
Protein Sequence MSETAPAAPAAPAPAEKTPIKKKARKAAGGAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGTATPKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKARAVKPKAAKPKTSKPKAAKPKKTAAKKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSETAPAAP
------CCCCCCCCC
23589303
2Acetylation------MSETAPAAP
------CCCCCCCCC
-
4Phosphorylation----MSETAPAAPAA
----CCCCCCCCCCC
27097102
17AcetylationAAPAPAEKTPIKKKA
CCCCCCCCCCCHHHH
25786129
18PhosphorylationAPAPAEKTPIKKKAR
CCCCCCCCCCHHHHH
23589303
21AcetylationPAEKTPIKKKARKAA
CCCCCCCHHHHHHHH
22902405
26MethylationPIKKKARKAAGGAKR
CCHHHHHHHHCCCCC
-
26AcetylationPIKKKARKAAGGAKR
CCHHHHHHHHCCCCC
-
34OtherAAGGAKRKASGPPVS
HHCCCCCCCCCCCHH
-
34SuccinylationAAGGAKRKASGPPVS
HHCCCCCCCCCCCHH
-
34SuccinylationAAGGAKRKASGPPVS
HHCCCCCCCCCCCHH
-
34MethylationAAGGAKRKASGPPVS
HHCCCCCCCCCCCHH
-
36PhosphorylationGGAKRKASGPPVSEL
CCCCCCCCCCCHHHH
23712012
41PhosphorylationKASGPPVSELITKAV
CCCCCCHHHHHHHHH
17683130
45PhosphorylationPPVSELITKAVAASK
CCHHHHHHHHHHHHH
22673903
46AcetylationPVSELITKAVAASKE
CHHHHHHHHHHHHHH
25786129
52AcetylationTKAVAASKERSGVSL
HHHHHHHHHCCCCCH
22902405
52OtherTKAVAASKERSGVSL
HHHHHHHHHCCCCCH
-
54CitrullinationAVAASKERSGVSLAA
HHHHHHHCCCCCHHH
-
54CitrullinationAVAASKERSGVSLAA
HHHHHHHCCCCCHHH
-
55PhosphorylationVAASKERSGVSLAAL
HHHHHHCCCCCHHHH
27097102
58PhosphorylationSKERSGVSLAALKKA
HHHCCCCCHHHHHHH
28432305
63AcetylationGVSLAALKKALAAAG
CCCHHHHHHHHHHCC
165047
64OtherVSLAALKKALAAAGY
CCHHHHHHHHHHCCC
-
75UbiquitinationAAGYDVEKNNSRIKL
HCCCCCHHCCCCCCC
-
75AcetylationAAGYDVEKNNSRIKL
HCCCCCHHCCCCCCC
165049
78PhosphorylationYDVEKNNSRIKLGLK
CCCHHCCCCCCCCHH
23800682
81AcetylationEKNNSRIKLGLKSLV
HHCCCCCCCCHHHHH
22902405
85OtherSRIKLGLKSLVSKGT
CCCCCCHHHHHHCCC
-
85AcetylationSRIKLGLKSLVSKGT
CCCCCCHHHHHHCCC
25786129
86PhosphorylationRIKLGLKSLVSKGTL
CCCCCHHHHHHCCCE
28432305
89PhosphorylationLGLKSLVSKGTLVQT
CCHHHHHHCCCEEEE
28432305
90OtherGLKSLVSKGTLVQTK
CHHHHHHCCCEEEEC
-
90AcetylationGLKSLVSKGTLVQTK
CHHHHHHCCCEEEEC
25786129
92PhosphorylationKSLVSKGTLVQTKGT
HHHHHCCCEEEECCC
25575281
97SuccinylationKGTLVQTKGTGASGS
CCCEEEECCCCCCCC
-
99PhosphorylationTLVQTKGTGASGSFK
CEEEECCCCCCCCEE
23984901
102PhosphorylationQTKGTGASGSFKLNK
EECCCCCCCCEECCC
27097102
104PhosphorylationKGTGASGSFKLNKKA
CCCCCCCCEECCCCC
27097102
106OtherTGASGSFKLNKKAAS
CCCCCCEECCCCCCC
-
106AcetylationTGASGSFKLNKKAAS
CCCCCCEECCCCCCC
25786129
117AcetylationKAASGEAKPKAKKAG
CCCCCCCCHHHHHHC
22902405
136AcetylationKKPAGAAKKPKKATG
CCCCCCCCCCCCCCC
25786129
146PhosphorylationKKATGTATPKKSTKK
CCCCCCCCCCCCCCC
29779826
150ADP-ribosylationGTATPKKSTKKTPKK
CCCCCCCCCCCCCCC
-
154PhosphorylationPKKSTKKTPKKAKKP
CCCCCCCCCCCCCCH
-
160AcetylationKTPKKAKKPAAAAGA
CCCCCCCCHHHHHCH
22902405
168AcetylationPAAAAGAKKAKSPKK
HHHHHCHHHCCCHHH
22902405
172PhosphorylationAGAKKAKSPKKAKAT
HCHHHCCCHHHHHHH
-
186MethylationTKAKKAPKSPAKARA
HHCCCCCCCHHHHHH
-
187PhosphorylationKAKKAPKSPAKARAV
HCCCCCCCHHHHHHC
21630457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of H14_RAT !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
26KAcetylation

-
26KAcetylation

-
54RCitrullination

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of H14_RAT !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of H14_RAT !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of H14_RAT

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Related Literatures of Post-Translational Modification

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