DC1L1_RAT - dbPTM
DC1L1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DC1L1_RAT
UniProt AC Q9QXU8
Protein Name Cytoplasmic dynein 1 light intermediate chain 1
Gene Name Dync1li1
Organism Rattus norvegicus (Rat).
Sequence Length 523
Subcellular Localization Cytoplasm . Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
Protein Description Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity)..
Protein Sequence MAAVGRVGSFGSSPPGLASTYASGPLANELASGSGGPAAGDDEDGQNLWSRILREVSTRSRSKLPTGKNVLLLGEDGAGKTSLIRRIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDFPASPQRRATAAQEDRDDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKIEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVGGSPGGGAAGASTSLPPSAKKSGQKPVLSDVHAELDRITRKPASVSPTTPPSPTEGEAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationAAVGRVGSFGSSPPG
CCCCCCCCCCCCCCC		24.4730240740
12PhosphorylationGRVGSFGSSPPGLAS
CCCCCCCCCCCCHHH		37.3530240740
13PhosphorylationRVGSFGSSPPGLAST
CCCCCCCCCCCHHHC		35.1830240740
197PhosphorylationLIRDFQEYVEPGEDF
HHHHHHHHCCCCCCC		10.1828551015
207PhosphorylationPGEDFPASPQRRATA
CCCCCCCCHHHHHHH		23.0823712012
213PhosphorylationASPQRRATAAQEDRD
CCHHHHHHHCHHCCC		22.2523984901
222PhosphorylationAQEDRDDSVVLPLGA
CHHCCCCCEEEECCC		20.5823984901
398PhosphorylationAGRPVDASPRVPGGS
CCCCCCCCCCCCCCC		14.58-
405PhosphorylationSPRVPGGSPRTPNRS
CCCCCCCCCCCCCCC		19.6827097102
408PhosphorylationVPGGSPRTPNRSVSS
CCCCCCCCCCCCCCC		28.4427097102
412PhosphorylationSPRTPNRSVSSNVAS
CCCCCCCCCCCCCCC		32.7527097102
414PhosphorylationRTPNRSVSSNVASVS
CCCCCCCCCCCCCCC		19.9027097102
415PhosphorylationTPNRSVSSNVASVSP
CCCCCCCCCCCCCCC		32.9227097102
419PhosphorylationSVSSNVASVSPIPAG
CCCCCCCCCCCCCCC		20.8827097102
421PhosphorylationSSNVASVSPIPAGSK
CCCCCCCCCCCCCCC		18.0227097102
427PhosphorylationVSPIPAGSKKIDPNM
CCCCCCCCCCCCCCC		32.6425575281
450PhosphorylationVLANFFNSLLSKKTG
HHHHHHHHHHCCCCC		26.0716641100
453PhosphorylationNFFNSLLSKKTGSPG
HHHHHHHCCCCCCCC		37.0825575281
486PhosphorylationLPPSAKKSGQKPVLS
CCCCCCCCCCCCCHH		45.83-
503PhosphorylationHAELDRITRKPASVS
HHHHHHHCCCCCCCC		33.2728689409
508PhosphorylationRITRKPASVSPTTPP
HHCCCCCCCCCCCCC		31.4927097102
510PhosphorylationTRKPASVSPTTPPSP
CCCCCCCCCCCCCCC		17.6528689409
512PhosphorylationKPASVSPTTPPSPTE
CCCCCCCCCCCCCCC		44.4123712012
513PhosphorylationPASVSPTTPPSPTEG
CCCCCCCCCCCCCCC		36.2623712012
516PhosphorylationVSPTTPPSPTEGEAS
CCCCCCCCCCCCCCC		45.7323712012
518PhosphorylationPTTPPSPTEGEAS--
CCCCCCCCCCCCC--		62.0423712012
523PhosphorylationSPTEGEAS-------
CCCCCCCC-------		36.1323712012
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
213TPhosphorylationKinasePKACAP17612
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DC1L1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DC1L1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DC1L1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DC1L1_RAT

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-414; SER-421;SER-450; SER-510; THR-512; THR-513; SER-516 AND THR-518, AND MASSSPECTROMETRY.

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