| UniProt ID | ARP2_RAT | |
|---|---|---|
| UniProt AC | Q5M7U6 | |
| Protein Name | Actin-related protein 2 | |
| Gene Name | Actr2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 394 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Cell projection . | |
| Protein Description | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).. | |
| Protein Sequence | MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDSQGRKV -------CCCCCCEE | 11.46 | - | |
| 117 | Phosphorylation | TEPPMNPTKNREKIV ECCCCCCCCCHHHHH | 35.63 | 25403869 | |
| 118 | Ubiquitination | EPPMNPTKNREKIVE CCCCCCCCCHHHHHH | 56.09 | - | |
| 207 | Phosphorylation | RGYAFNHSADFETVR HCCCCCCCCCHHHHH | 30.55 | 25403869 | |
| 225 | Phosphorylation | EKLCYVGYNIEQEQK HHHHCCCCCCHHHHH | 11.70 | - | |
| 299 | Acetylation | DTRSEFYKHIVLSGG CCHHHHHHHHEECCC | 31.98 | 22902405 | |
| 322 | Acetylation | SRLERELKQLYLERV HHHHHHHHHHHHHHH | 33.24 | 22902405 | |
| 331 | Acetylation | LYLERVLKGDVEKLS HHHHHHHCCCHHHHH | 50.65 | 72608601 | |
| 336 | Acetylation | VLKGDVEKLSKFKIR HHCCCHHHHHCCEEE | 58.89 | 72588467 | |
| 339 | Acetylation | GDVEKLSKFKIRIED CCHHHHHCCEEEECC | 62.20 | 22902405 | |
| 368 | Acetylation | LADIMKDKDNFWMTR HHHHHHCCCCCEECH | 49.40 | 22902405 | |
| 368 | Succinylation | LADIMKDKDNFWMTR HHHHHHCCCCCEECH | 49.40 | 26843850 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARP2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARP2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARP2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ARP2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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