IF5A1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A1_RAT
• UniProt AC: Q3T1J1
• Protein Name: Eukaryotic translation initiation factor 5A-1
• Gene Name: Eif5a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 154
• Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
• Protein Description: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation..
• Protein Sequence: MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADDLDFET ------CCCCCCCCC	21.01	-
9	Phosphorylation	ADDLDFETGDAGASA CCCCCCCCCCCCCCC	40.11	21373199
27	Acetylation	MQCSALRKNGFVVLK CCCHHHHHCCEEEEC	63.37	22902405
39	Acetylation	VLKGRPCKIVEMSTS EECCCEEEEEEEECC	53.09	22902405
44	Phosphorylation	PCKIVEMSTSKTGKH EEEEEEEECCCCCCC	18.94	23984901
45	Phosphorylation	CKIVEMSTSKTGKHG EEEEEEECCCCCCCC	32.69	23984901
46	Phosphorylation	KIVEMSTSKTGKHGH EEEEEECCCCCCCCC	22.40	23984901
47	Acetylation	IVEMSTSKTGKHGHA EEEEECCCCCCCCCE	62.48	25786129
50	Hypusine	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
50	Other	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
65	Phosphorylation	LVGIDIFTGKKYEDI EEEEECCCCCCHHHC	48.72	23984901
67	Acetylation	GIDIFTGKKYEDICP EEECCCCCCHHHCCC	49.47	22902405
75	Phosphorylation	KYEDICPSTHNMDVP CHHHCCCCCCCCCCC	37.58	23984901
76	Phosphorylation	YEDICPSTHNMDVPN HHHCCCCCCCCCCCC	11.47	23984901
85	Ubiquitination	NMDVPNIKRNDFQLI CCCCCCCCCCCEEEE	52.36	-
121	Acetylation	LPEGDLGKEIEQKYD CCCCCHHHHHHHHHC	63.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IF5A1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.