SC6A3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC6A3_RAT
• UniProt AC: P23977
• Protein Name: Sodium-dependent dopamine transporter
• Gene Name: Slc6a3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 619
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals..
• Protein Sequence: MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKSKCSVG ------CCCCCCCCC	45.71	12660249
4	Phosphorylation	----MSKSKCSVGPM ----CCCCCCCCCCC	31.42	12660249
7	Phosphorylation	-MSKSKCSVGPMSSV -CCCCCCCCCCCCCC	33.57	12660249
12	Phosphorylation	KCSVGPMSSVVAPAK CCCCCCCCCCEECCC	24.10	12660249
13	Phosphorylation	CSVGPMSSVVAPAKE CCCCCCCCCEECCCC	17.85	12660249
21	Phosphorylation	VVAPAKESNAVGPRE CEECCCCCCCCCCCE	29.40	11994276
53	Phosphorylation	TLINPPQTPVEAQER CCCCCCCCCCHHHHH	34.77	22722938
62	Phosphorylation	VEAQERETWSKKIDF CHHHHHHHHHHHHHH	41.06	12660249
181	N-linked_Glycosylation	DLPWIHCNNTWNSPN CCCEEECCCCCCCCC	34.50	-
188	N-linked_Glycosylation	NNTWNSPNCSDAHAS CCCCCCCCCCCCCCC	37.43	-
196	N-linked_Glycosylation	CSDAHASNSSDGLGL CCCCCCCCCCCCCCC	46.44	-
204	N-linked_Glycosylation	SSDGLGLNDTFGTTP CCCCCCCCCCCCCCC	44.47	-
260	Phosphorylation	SLWKGVKTSGKVVWI HHHCCCCCCCCEEEE	40.06	-
261	Phosphorylation	LWKGVKTSGKVVWIT HHCCCCCCCCEEEEE	30.79	-
580	S-palmitoylation	IYATYKFCSLPGSFR HHHHCHHCCCCCCHH	3.41	30965003
581	Phosphorylation	YATYKFCSLPGSFRE HHHCHHCCCCCCHHH	40.51	12660249
595	Phosphorylation	EKLAYAITPEKDHQL HHHEEEECCCCCCCC	19.75	12660249
612	Phosphorylation	RGEVRQFTLRHWLLL HHHHHHHHHHHHHHC	17.97	12660249

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
7	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
7	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
13	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
13	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
53	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
53	T	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
53	T	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC6A3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC6A3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_RAT	Nedd4	physical	16885233
EPN1_RAT	Epn1	physical	16885233
PRKN_RAT	Park2	physical	17873367

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.