HXA1_HUMAN - dbPTM
HXA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXA1_HUMAN
UniProt AC P49639
Protein Name Homeobox protein Hox-A1
Gene Name HOXA1
Organism Homo sapiens (Human).
Sequence Length 335
Subcellular Localization Nucleus.
Protein Description Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments..
Protein Sequence MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQIGSPHHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationGTCSARAYPSDHRIT
CCCCCCEECCCCCEE		9.56-
30PhosphorylationCSARAYPSDHRITTF
CCCCEECCCCCEEEE		33.11-
255PhosphorylationFHFNKYLTRARRVEI
HHHHHHHHHHHHHHH		21.13-
296PhosphorylationKEGLLPISPATPPGN
HCCCCCCCCCCCCCC		13.4228450419
299PhosphorylationLLPISPATPPGNDEK
CCCCCCCCCCCCCHH		33.1419664994
322PhosphorylationSSSPCVPSPGSSTSD
CCCCCCCCCCCCCCC		22.8428450419
325PhosphorylationPCVPSPGSSTSDTLT
CCCCCCCCCCCCCCC		33.5528450419
326PhosphorylationCVPSPGSSTSDTLTT
CCCCCCCCCCCCCCC		37.5328450419
334PhosphorylationTSDTLTTSH------
CCCCCCCCC------		23.20-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HXA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDFI_HUMANMDFIphysical
16189514
PLS1_HUMANPLSCR1physical
16189514
CHIC2_HUMANCHIC2physical
16189514
KR412_HUMANKRTAP4-12physical
16189514
FBLN4_HUMANEFEMP2physical
16189514
TPC6A_HUMANTRAPPC6Aphysical
16189514
LPXN_HUMANLPXNphysical
16189514
TRIP6_HUMANTRIP6physical
16189514
PKNX1_HUMANPKNOX1physical
9582372
APRIO_HUMANPRNPphysical
18482256
PRIO_HUMANPRNPphysical
18482256
SUV91_HUMANSUV39H1physical
23455924
P85A_HUMANPIK3R1physical
21988832
KDM1A_HUMANKDM1Aphysical
23455924
ANM6_HUMANPRMT6physical
23455924
HXA1_HUMANHOXA1physical
25416956
KRA59_HUMANKRTAP5-9physical
25416956
K1H1_HUMANKRT31physical
25416956
PBX2_HUMANPBX2physical
25416956
SDCB1_HUMANSDCBPphysical
25416956
TRAF1_HUMANTRAF1physical
25416956
GO45_HUMANBLZF1physical
25416956
RGS20_HUMANRGS20physical
25416956
CHRD_HUMANCHRDphysical
25416956
KRT38_HUMANKRT38physical
25416956
SPY1_HUMANSPRY1physical
25416956
N42L2_HUMANN4BP2L2physical
25416956
RBPMS_HUMANRBPMSphysical
25416956
RGS17_HUMANRGS17physical
25416956
PP13_HUMANLGALS13physical
25416956
ATL4_HUMANADAMTSL4physical
25416956
ALG13_HUMANALG13physical
25416956
CCD33_HUMANCCDC33physical
25416956
KR412_HUMANKRTAP4-12physical
25416956
KRA32_HUMANKRTAP3-2physical
25416956
KRA92_HUMANKRTAP9-2physical
25416956
KRA94_HUMANKRTAP9-4physical
25416956
KRA42_HUMANKRTAP4-2physical
25416956
K1C40_HUMANKRT40physical
25416956
MGT5B_HUMANMGAT5Bphysical
25416956
LCE4A_HUMANLCE4Aphysical
25416956
TRI42_HUMANTRIM42physical
25416956
LCE1B_HUMANLCE1Bphysical
25416956
LCE3E_HUMANLCE3Ephysical
25416956
KR122_HUMANKRTAP12-2physical
25416956
KR121_HUMANKRTAP12-1physical
25416956
TB10C_HUMANTBC1D10Cphysical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR101_HUMANKRTAP10-1physical
25416956
KR10B_HUMANKRTAP10-11physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
KR124_HUMANKRTAP12-4physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
KR261_HUMANKRTAP26-1physical
25416956
KRA56_HUMANKRTAP5-6physical
25416956
KR411_HUMANKRTAP4-11physical
25416956
ZN703_HUMANZNF703physical
26186194
ZN503_HUMANZNF503physical
26186194
TLE1_HUMANTLE1physical
26186194
HXA1_HUMANHOXA1physical
21516116
ZN703_HUMANZNF703physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
601536Athabaskan brainstem dysgenesis syndrome (ABDS)
601536Bosley-Salih-Alorainy syndrome (BSAS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXA1_HUMAN

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Related Literatures of Post-Translational Modification

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