ACHD_HUMAN - dbPTM
ACHD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACHD_HUMAN
UniProt AC Q07001
Protein Name Acetylcholine receptor subunit delta
Gene Name CHRND
Organism Homo sapiens (Human).
Sequence Length 517
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein.
Protein Description After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
Protein Sequence MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationHLFQEKGYNKELRPV
HHHHHCCCCCCCCCC		33.84-
65PhosphorylationLTLSNLISLKEVEET
HHHHHCCCHHHHHHH		36.2324719451
97N-linked_GlycosylationWNAEEFGNISVLRLP
ECHHHHCCEEEEECC		28.78UniProtKB CARBOHYD
164N-linked_GlycosylationYFPFDWQNCSLKFSS
ECCCCCCCCEEEEEC		17.06UniProtKB CARBOHYD
230PhosphorylationDPRAPLDSPSRQDIT
CCCCCCCCCCCCCCE		32.24-
232PhosphorylationRAPLDSPSRQDITFY
CCCCCCCCCCCCEEE		46.67-
370PhosphorylationRPAEDGPSPGALVRR
CCCCCCCCCCHHEEC		41.31-
378PhosphorylationPGALVRRSSSLGYIS
CCHHEECCCCCCCCC		17.4529255136
379PhosphorylationGALVRRSSSLGYISK
CHHEECCCCCCCCCH		27.9826437602
380PhosphorylationALVRRSSSLGYISKA
HHEECCCCCCCCCHH		27.3629255136
383PhosphorylationRRSSSLGYISKAEEY
ECCCCCCCCCHHHHE		13.8129255136
385PhosphorylationSSSLGYISKAEEYFL
CCCCCCCCHHHHEEE		19.8229255136
390PhosphorylationYISKAEEYFLLKSRS
CCCHHHHEEEECCHH		7.3429255136
416PhosphorylationGLARRLTTARRPPAS
CHHHHHHHCCCCCCC		23.8224719451
478PhosphorylationRLCLFVVTPVMVVGT
HHHHHHHCCEEEECC		12.59-
485PhosphorylationTPVMVVGTAWIFLQG
CCEEEECCHHHHHHC		13.75-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
362SPhosphorylationKinasePKA-FAMILY-GPS
362SPhosphorylationKinasePKC-FAMILY-GPS
390YPhosphorylationKinaseTYR-KINASES-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACHD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACHD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACHA_HUMANCHRNA1physical
8910344
PLPR3_HUMANLPPR3physical
28514442
DJC18_HUMANDNAJC18physical
28514442
SC11C_HUMANSEC11Cphysical
28514442
SIDT2_HUMANSIDT2physical
28514442
PKD2_HUMANPKD2physical
28514442
P_HUMANOCA2physical
28514442
ST7L_HUMANST7Lphysical
28514442
E2AK3_HUMANEIF2AK3physical
28514442
CNNM1_HUMANCNNM1physical
28514442
D19L4_HUMANDPY19L4physical
28514442
SPP2B_HUMANSPPL2Bphysical
28514442
SPPL3_HUMANSPPL3physical
28514442
TPST2_HUMANTPST2physical
28514442
S12A4_HUMANSLC12A4physical
28514442
BT2A2_HUMANBTN2A2physical
28514442
GPC5B_HUMANGPRC5Bphysical
28514442
MRP7_HUMANABCC10physical
28514442
MFAP3_HUMANMFAP3physical
28514442
WLS_HUMANWLSphysical
28514442
S47A1_HUMANSLC47A1physical
28514442
ATG9A_HUMANATG9Aphysical
28514442
ERG1_HUMANSQLEphysical
28514442
PDZD8_HUMANPDZD8physical
28514442
S27A3_HUMANSLC27A3physical
28514442
TMTC3_HUMANTMTC3physical
28514442
ABCA3_HUMANABCA3physical
28514442
APOL2_HUMANAPOL2physical
28514442
ALG9_HUMANALG9physical
28514442
LCLT1_HUMANLCLAT1physical
28514442
TM39A_HUMANTMEM39Aphysical
28514442
EDA_HUMANEDAphysical
28514442
SGCB_HUMANSGCBphysical
28514442
K2013_HUMANKIAA2013physical
28514442
SRBP2_HUMANSREBF2physical
28514442
ST7_HUMANST7physical
28514442
CISD2_HUMANCISD2physical
28514442
DHRS7_HUMANDHRS7physical
28514442
TUSC3_HUMANTUSC3physical
28514442
ERGI3_HUMANERGIC3physical
28514442
F189B_HUMANFAM189Bphysical
28514442
TYW1_HUMANTYW1physical
28514442
SEC20_HUMANBNIP1physical
28514442
CA043_HUMANC1orf43physical
28514442
F213A_HUMANFAM213Aphysical
28514442
BI1_HUMANTMBIM6physical
28514442
ERGI2_HUMANERGIC2physical
28514442
TMPPE_HUMANTMPPEphysical
28514442
POMT2_HUMANPOMT2physical
28514442
FA8A1_HUMANFAM8A1physical
28514442
EXTL3_HUMANEXTL3physical
28514442
ATF6B_HUMANATF6Bphysical
28514442
CCPG1_HUMANCCPG1physical
28514442
Drug and Disease Associations
Kegg Disease
H00770 Congenital myasthenic syndrome
H00986 Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pt
OMIM Disease
253290Multiple pterygium syndrome, lethal type (LMPS)
616321Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A)
616322Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B)
616323Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C)
Kegg Drug
D00492 Pancuronium bromide (JP16/USAN/INN); Pavulon (TN)
D00611 Mecamylamine hydrochloride (USP); Inversine (TN)
D00758 Atracurium besylate (USP); Atracurium besilate (INN); Tracrium (TN)
D00759 Cisatracurium besylate (USAN); Cisatracurium besilate (INN); Nimbex (TN)
D00760 Doxacurium chloride (USAN/INN); Nuromax (TN)
D00763 Mivacurium chloride (USAN/INN); Mivacron (TN)
D00764 Pipecuronium bromide (USAN/INN); Arduan (TN)
D00765 Rocuronium bromide (JAN/USAN/INN); Zemuron (TN)
D00766 Succinylcholine chloride (USP); Suxamethonium chloride (INN); Anectine (TN); Quelicin (TN)
D00767 Vecuronium bromide (JAN/USAN/INN); Norcuron (TN)
D00999 Acetylcholine chloride (JP16/USP/INN); Miochol (TN)
D02202 Lobeline hydrochloride (JAN)
D02207 Tubocurarine chloride hydrate (JAN); Tubocurarine chloride (USP); Tubocurarine chloride (TN)
D02275 Suxamethonium chloride hydrate (JP16); Suxamethonium chloride dihydrate; Succin (TN)
D02292 Gallamine triethiodide (USP); Flaxedil (TN)
D02364 Lobeline (INN)
D04303 Gantacurium chloride (USAN/INN)
D05703 Rapacuronium bromide (USAN/INN); Raplon (TN)
D07272 Dimethyltubocurarine (BAN)
D08138 Lobeline sulfate; Smokeless (TN)
D08655 Tubocurarine chloride (INN); Tubaine (TN); Tubocurarine Chloride (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACHD_HUMAN

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Related Literatures of Post-Translational Modification

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