P_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P_HUMAN
• UniProt AC: Q04671
• Protein Name: P protein
• Gene Name: OCA2
• Organism: Homo sapiens (Human).
• Sequence Length: 838
• Subcellular Localization: Melanosome membrane ; Multi-pass membrane protein .
• Protein Description: Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color..
• Protein Sequence: MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	AVELLQTSVPSGLAE HHHHHHHCCCCCHHH	21.04	29507054
145	Phosphorylation	YLLSREVSGLSASAS HHHHHHHHCCCCCCC	29.30	-
153	Phosphorylation	GLSASASSEKGDLLD CCCCCCCCCCCCCCC	42.94	29507054
214	N-linked_Glycosylation	LALSPLENYSVNLSS HHCCCCCCCCCCCHH	41.90	UniProtKB CARBOHYD
218	N-linked_Glycosylation	PLENYSVNLSSHVDS CCCCCCCCCHHHCCC	28.41	UniProtKB CARBOHYD
273	N-linked_Glycosylation	RPQQVTHNWTVYLNP CCCEECCCEEEEECC	27.09	UniProtKB CARBOHYD
289	Phosphorylation	RSEHSVMSRTFEVLT CCCCCHHHHEEEEHH	26.47	29978859
291	Phosphorylation	EHSVMSRTFEVLTRE CCCHHHHEEEEHHCC	19.48	29978859
296	Phosphorylation	SRTFEVLTRETVSIS HHEEEEHHCCEEEEE	31.47	29978859
299	Phosphorylation	FEVLTRETVSISIRA EEEHHCCEEEEEEHH	19.09	29978859
301	Phosphorylation	VLTRETVSISIRASL EHHCCEEEEEEHHHH	20.31	29978859
303	Phosphorylation	TRETVSISIRASLQQ HCCEEEEEEHHHHHH	9.87	29978859
322	Phosphorylation	PLLMAHQYLRGSVET HHHHHHHHHCCCHHH	6.62	-
442	N-linked_Glycosylation	VLSAFLDNVTTMLLF HHHHHHHCHHHHHHH	34.87	UniProtKB CARBOHYD
598	Phosphorylation	HTFHRQISQEDKNWE HHHHHHHCHHHCCHH	21.12	26029660
613	Ubiquitination	TNIQELQKKHRISDG HHHHHHHHHHCCCHH	64.27	-
781	N-linked_Glycosylation	FGACLGGNGTLIGAS HCHHHCCCCCEEECC	38.18	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of P_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.