| UniProt ID | ACHA_HUMAN | |
|---|---|---|
| UniProt AC | P02708 | |
| Protein Name | Acetylcholine receptor subunit alpha | |
| Gene Name | CHRNA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 482 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.. | |
| Protein Sequence | MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 186 | N-linked_Glycosylation | HFPFDEQNCSMKLGT ECCCCCCCCEEEEEE | 20.13 | UniProtKB CARBOHYD | |
| 291 | Phosphorylation | SGEKMTLSISVLLSL CCCCCCHHHHHHHHH | 12.03 | 19690332 | |
| 297 | Phosphorylation | LSISVLLSLTVFLLV HHHHHHHHHHHHHHH | 20.17 | 19690332 | |
| 312 | Phosphorylation | IVELIPSTSSAVPLI HHHHCCCCCCCCHHH | 22.73 | 19690332 | |
| 322 | Phosphorylation | AVPLIGKYMLFTMVF CCHHHHHHHHHHHHH | 8.21 | 24043423 | |
| 326 | Phosphorylation | IGKYMLFTMVFVIAS HHHHHHHHHHHHHHH | 14.41 | 24043423 | |
| 333 | Phosphorylation | TMVFVIASIIITVIV HHHHHHHHHHHHHHH | 11.82 | 24043423 | |
| 337 | Phosphorylation | VIASIIITVIVINTH HHHHHHHHHHHCCCC | 8.18 | 24043423 | |
| 343 | Phosphorylation | ITVIVINTHHRSPST HHHHHCCCCCCCCCC | 14.13 | 24043423 | |
| 364 | Phosphorylation | VRKVFIDTIPNIMFF HHHHHHHHCCHHHEE | 33.25 | 22210691 | |
| 372 | Phosphorylation | IPNIMFFSTMKRPSR CCHHHEECCCCCCCH | 19.14 | 22210691 | |
| 373 | Phosphorylation | PNIMFFSTMKRPSRE CHHHEECCCCCCCHH | 22.89 | 22210691 | |
| 384 | Acetylation | PSREKQDKKIFTEDI CCHHHCCCCCCCCCC | 45.32 | 7669687 | |
| 385 | Acetylation | SREKQDKKIFTEDID CHHHCCCCCCCCCCC | 51.87 | 7669699 | |
| 446 | Phosphorylation | NAAAEWKYVAMVMDH CHHHHHHHHHHHHHH | 8.43 | 25332170 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACHA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACHA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACHA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ACHG_HUMAN | CHRNG | physical | 7695910 | |
| ACHD_HUMAN | CHRND | physical | 7695910 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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