| UniProt ID | ACHG_HUMAN | |
|---|---|---|
| UniProt AC | P07510 | |
| Protein Name | Acetylcholine receptor subunit gamma | |
| Gene Name | CHRNG | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 517 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.. | |
| Protein Sequence | MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 52 | N-linked_Glycosylation | ERDSDVVNVSLKLTL CCCCCCCEEEEEEEH | 19.94 | UniProtKB CARBOHYD | |
| 163 | N-linked_Glycosylation | YFPFDWQNCSLIFQS ECCCCCCCEEEEEEE | 17.06 | UniProtKB CARBOHYD | |
| 285 | Phosphorylation | INVLLAQTVFLFLVA HHHHHHHHHHHHHHH | 13.97 | 22817900 | |
| 298 | Phosphorylation | VAKKVPETSQAVPLI HHCCCCCCCCHHHHH | 21.77 | 30622161 | |
| 299 | Phosphorylation | AKKVPETSQAVPLIS HCCCCCCCCHHHHHH | 17.93 | 30622161 | |
| 316 | Phosphorylation | LTFLLVVTILIVVNA HHHHHHHHHHHHHHH | 11.55 | - | |
| 330 | Phosphorylation | AVVVLNVSLRSPHTH HHHHHCCCCCCCCHH | 19.59 | - | |
| 497 | Phosphorylation | GIFLMAHYNRVPALP HHHHHHCCCCCCCCC | 8.64 | 22817900 | |
| 512 | Phosphorylation | FPGDPRPYLPSPD-- CCCCCCCCCCCCC-- | 32.31 | 18083107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACHG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACHG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACHG_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| K1H1_HUMAN | KRT31 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR109_HUMAN | KRTAP10-9 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| ACL6B_HUMAN | ACTL6B | physical | 26186194 | |
| ACL6B_HUMAN | ACTL6B | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00986 | Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pt | |||||
| OMIM Disease | ||||||
| 253290 | Multiple pterygium syndrome, lethal type (LMPS) | |||||
| 265000 | Multiple pterygium syndrome, Escobar variant (EVMPS) | |||||
| Kegg Drug | ||||||
| D00492 | Pancuronium bromide (JP16/USAN/INN); Pavulon (TN) | |||||
| D00611 | Mecamylamine hydrochloride (USP); Inversine (TN) | |||||
| D00758 | Atracurium besylate (USP); Atracurium besilate (INN); Tracrium (TN) | |||||
| D00759 | Cisatracurium besylate (USAN); Cisatracurium besilate (INN); Nimbex (TN) | |||||
| D00760 | Doxacurium chloride (USAN/INN); Nuromax (TN) | |||||
| D00763 | Mivacurium chloride (USAN/INN); Mivacron (TN) | |||||
| D00764 | Pipecuronium bromide (USAN/INN); Arduan (TN) | |||||
| D00765 | Rocuronium bromide (JAN/USAN/INN); Zemuron (TN) | |||||
| D00766 | Succinylcholine chloride (USP); Suxamethonium chloride (INN); Anectine (TN); Quelicin (TN) | |||||
| D00767 | Vecuronium bromide (JAN/USAN/INN); Norcuron (TN) | |||||
| D00999 | Acetylcholine chloride (JP16/USP/INN); Miochol (TN) | |||||
| D02202 | Lobeline hydrochloride (JAN) | |||||
| D02207 | Tubocurarine chloride hydrate (JAN); Tubocurarine chloride (USP); Tubocurarine chloride (TN) | |||||
| D02275 | Suxamethonium chloride hydrate (JP16); Suxamethonium chloride dihydrate; Succin (TN) | |||||
| D02292 | Gallamine triethiodide (USP); Flaxedil (TN) | |||||
| D02364 | Lobeline (INN) | |||||
| D04303 | Gantacurium chloride (USAN/INN) | |||||
| D05703 | Rapacuronium bromide (USAN/INN); Raplon (TN) | |||||
| D07272 | Dimethyltubocurarine (BAN) | |||||
| D08138 | Lobeline sulfate; Smokeless (TN) | |||||
| D08655 | Tubocurarine chloride (INN); Tubaine (TN); Tubocurarine Chloride (TN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285, AND MASSSPECTROMETRY. | |
