dbPTM

HAVR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HAVR2_HUMAN
UniProt AC	Q8TDQ0
Protein Name	Hepatitis A virus cellular receptor 2
Gene Name	HAVCR2
Organism	Homo sapiens (Human).
Sequence Length	301
Subcellular Localization	Membrane Single-pass type I membrane protein . Cell junction . Localizes to the immunological synapse between CD8+ T-cells and target cells.
Protein Description	Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. [PubMed: 24825777 Regulates macrophage activation]
Protein Sequence	MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQNLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEEPNEYYCYVSSRQQPSQPLGCRFAMP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	ENVTLADSGIYCCRI ECEEECCCCEEEEEE	22.83	30377224
108	Phosphorylation	TLADSGIYCCRIQIP EECCCCEEEEEEECC	6.77	30377224
126	Acetylation	NDEKFNLKLVIKPAK CCCCCCEEEEEECCC	41.64	7370233
145	O-linked_Glycosylation	PTRQRDFTAAFPRML CCCCCCHHHHHCCHH	22.74	22171320
153	Phosphorylation	AAFPRMLTTRGHGPA HHHCCHHHCCCCCCC	12.71	-
154	Phosphorylation	AFPRMLTTRGHGPAE HHCCHHHCCCCCCCC	30.60	-
172	N-linked_Glycosylation	LGSLPDINLTQISTL CCCCCCCCHHHHHHH	44.40	UniProtKB CARBOHYD
174	O-linked_Glycosylation	SLPDINLTQISTLAN CCCCCCHHHHHHHHH	21.26	OGP
178	O-linked_Glycosylation	INLTQISTLANELRD CCHHHHHHHHHHHHH	31.36	OGP
238	Phosphorylation	KEKIQNLSLISLANL HHHHHCEEEEECCCC	31.07	28857561
241	Phosphorylation	IQNLSLISLANLPPS HHCEEEEECCCCCCC	27.07	28857561
265	Phosphorylation	IRSEENIYTIEENVY CCCCCCEEEEECCEE	17.16	17069754
272	Phosphorylation	YTIEENVYEVEEPNE EEEECCEEECCCCCC	26.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
265	Y	Phosphorylation	Kinase	ITK	Q08881	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HAVR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HAVR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LCK_HUMAN	LCK	physical	22863785
PHLP1_HUMAN	PHLPP1	physical	28514442
ZDHC5_HUMAN	ZDHHC5	physical	28514442
M3K21_HUMAN	KIAA1804	physical	28514442
DIP2B_HUMAN	DIP2B	physical	28514442
DEN6A_HUMAN	DENND6A	physical	28514442
CLDN1_HUMAN	CLDND1	physical	28514442
CBPC5_HUMAN	AGBL5	physical	28514442
GOGA7_HUMAN	GOLGA7	physical	28514442
TSN7_HUMAN	TSPAN7	physical	28514442
DIP2A_HUMAN	DIP2A	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
KDM1B_HUMAN	KDM1B	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
MTMR5_HUMAN	SBF1	physical	28514442
CNKR3_HUMAN	CNKSR3	physical	28514442
DGKQ_HUMAN	DGKQ	physical	28514442
P4K2B_HUMAN	PI4K2B	physical	28514442
IL1AP_HUMAN	IL1RAP	physical	28514442
CISD3_HUMAN	CISD3	physical	28514442
PK3CA_HUMAN	PIK3CA	physical	28514442
AVR2A_HUMAN	ACVR2A	physical	28514442
PK3CB_HUMAN	PIK3CB	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
RHBT3_HUMAN	RHOBTB3	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
CERK1_HUMAN	CERK	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
S20A2_HUMAN	SLC20A2	physical	28514442
AT132_HUMAN	ATP13A2	physical	28514442
TTF2_HUMAN	TTF2	physical	28514442
CNTP1_HUMAN	CNTNAP1	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
MTMR1_HUMAN	MTMR1	physical	28514442
NISCH_HUMAN	NISCH	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
WDR36_HUMAN	WDR36	physical	28514442
P55G_HUMAN	PIK3R3	physical	28514442
PLPL6_HUMAN	PNPLA6	physical	28514442
P85B_HUMAN	PIK3R2	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
PKHH3_HUMAN	PLEKHH3	physical	28514442
MYO1D_HUMAN	MYO1D	physical	28514442
PKP4_HUMAN	PKP4	physical	28514442
PLCA_HUMAN	AGPAT1	physical	28514442
MELK_HUMAN	MELK	physical	28514442
SNX17_HUMAN	SNX17	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
UTP18_HUMAN	UTP18	physical	28514442
PKN2_HUMAN	PKN2	physical	28514442
PLD2_HUMAN	PLD2	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442
JAK1_HUMAN	JAK1	physical	28514442
UTP4_HUMAN	CIRH1A	physical	28514442
P3C2A_HUMAN	PIK3C2A	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
ERBB2_HUMAN	ERBB2	physical	28514442
P85A_HUMAN	PIK3R1	physical	28514442
PIGM_HUMAN	PIGM	physical	28514442
LPCT4_HUMAN	LPCAT4	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
WDR44_HUMAN	WDR44	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HAVR2_HUMAN

Related Literatures of Post-Translational Modification

O-linked Glycosylation
Reference	PubMed
"Human urinary glycoproteomics; attachment site specific analysis ofN-and O-linked glycosylations by CID and ECD."; Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.; Mol. Cell. Proteomics 0:0-0(2011). Cited for: GLYCOSYLATION AT THR-145, STRUCTURE OF CARBOHYDRATES, AND MASSSPECTROMETRY.	22171320 [Abstract]