CBPC5_HUMAN - dbPTM
CBPC5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBPC5_HUMAN
UniProt AC Q8NDL9
Protein Name Cytosolic carboxypeptidase-like protein 5
Gene Name AGBL5
Organism Homo sapiens (Human).
Sequence Length 886
Subcellular Localization Cytoplasm, cytosol . Nucleus . Cytoplasm, cytoskeleton, spindle . Midbody . Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the
Protein Description Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS..
Protein Sequence MELRCGGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQPLNHRPAGSLAPSPAPTSSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMVIGKGLLGTGARMPCIKTRLQARPRLGRGSPPTRRGMKGSSGPTSPTPRTRESSELELGSCSATPGLPQARPPRPRSAPAFSPISCSLSDSPSWNCYSRGPLGQPEVCFVPKSPPLTVSPRV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
198PhosphorylationYHRELLCYSLDGLRV
ECHHHHHHCCCCCEE		16.5526852163
199PhosphorylationHRELLCYSLDGLRVD
CHHHHHHCCCCCEEE		20.9826852163
302PhosphorylationDGVVRGHYRTDSRGV
CCCCCCCCCCCCCCC		20.313724323
315PhosphorylationGVNLNRQYLKPDAVL
CCCCCCCCCCCCCCC		17.297491085
317UbiquitinationNLNRQYLKPDAVLHP
CCCCCCCCCCCCCCH		35.60-
390UbiquitinationRHNAEAWKQTEPAEQ
HHCHHHHHCCCCHHH		55.1629967540
539PhosphorylationCHDNGRASPPPPPAF
HCCCCCCCCCCCCCC		36.2628857561
548PhosphorylationPPPPAFPSRYTVELF
CCCCCCCCCHHHHHH		31.3128985074
604PhosphorylationVRNSRGLSSTLNVGV
HHHCCCCCCCCCCCC		24.8946160349
605O-linked_GlycosylationRNSRGLSSTLNVGVN
HHCCCCCCCCCCCCC		41.7930379171
606PhosphorylationNSRGLSSTLNVGVNK
HCCCCCCCCCCCCCC		20.9823917254
632PhosphorylationNGLPVSCSENTLSRA
CCCCCCCCCCHHHCC		26.7882900389
658PhosphorylationSSSSQQNSPQMKNSP
CCCCCCCCCCCCCCC		16.5128985074
664PhosphorylationNSPQMKNSPSFPFHG
CCCCCCCCCCCCCCC		19.1925627689
734AcetylationSGPASSHKLGSCLLP
CCCCCCCCCCCCCCC		57.397693211
794PhosphorylationRPRLGRGSPPTRRGM
CCCCCCCCCCCCCCC		26.7582900395
808PhosphorylationMKGSSGPTSPTPRTR
CCCCCCCCCCCCCCC		51.3622496350
809PhosphorylationKGSSGPTSPTPRTRE
CCCCCCCCCCCCCCC		29.8828102081
811PhosphorylationSSGPTSPTPRTRESS
CCCCCCCCCCCCCCC		25.7722496350
841PhosphorylationARPPRPRSAPAFSPI
CCCCCCCCCCCCCCC		41.09-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CBPC5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBPC5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBPC5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CBPC5_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CBPC5_HUMAN

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Related Literatures of Post-Translational Modification

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