DGKQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKQ_HUMAN
• UniProt AC: P52824
• Protein Name: Diacylglycerol kinase theta
• Gene Name: DGKQ
• Organism: Homo sapiens (Human).
• Sequence Length: 942
• Subcellular Localization: Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton . Nucleus . Nucleus speckle . Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189). Translocates to the plasma membrane in response to steroid hormone receptor stimulati
• Protein Description: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity..
• Protein Sequence: MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTLKIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAWAGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPKSTARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVRQVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQGAVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RAWLGGGSPRPGSPA CEECCCCCCCCCCCC	22.47	27422710
22	Phosphorylation	GGSPRPGSPACSPVL CCCCCCCCCCCCCCC	16.41	23401153
26	Phosphorylation	RPGSPACSPVLGSGG CCCCCCCCCCCCCCC	21.83	23401153
31	Phosphorylation	ACSPVLGSGGRARPG CCCCCCCCCCCCCCC	33.63	28450419
51	Methylation	GPERAGVRAPGPAAA CHHHCCCCCCCCCCC	33.86	-
202	Ubiquitination	ARCEVCRKTCGSSDV CCCHHHHHHCCCCCH	42.94	-
258	Ubiquitination	LLPGGFSKTQSFRIV ECCCCCCCCEEEEEE	48.61	-
297	Ubiquitination	QATPESGKQTLKIFD CCCCCCCCCEEEEEC	49.76	-
320	Phosphorylation	QFRLVTVSRLAGAEE HEEEEEHHHHCCHHH	16.53	24719451
371	Phosphorylation	KAGSAVISEEGRSPG CCCCEEECCCCCCCC	24.01	28450419
376	Phosphorylation	VISEEGRSPGSGEAT EECCCCCCCCCCCCC	44.46	28450419
379	Phosphorylation	EEGRSPGSGEATPEA CCCCCCCCCCCCHHH	36.52	28450419
383	Phosphorylation	SPGSGEATPEAWVIR CCCCCCCCHHHHHHH	19.84	28450419
400	Ubiquitination	PRAQEVLKIYPGWLK CHHHHHHHHCCCCEE	45.42	-
412	Phosphorylation	WLKVGVAYVSVRVTP CEEEEEEEEEEEECC	7.28	28152594
414	Phosphorylation	KVGVAYVSVRVTPKS EEEEEEEEEEECCCH	7.48	28152594
608	Phosphorylation	KGRDLLCSFRKLLNP CHHHHHHHHHHHCCH	28.23	24719451
835	Phosphorylation	LWGSDSDTRFEKPRM CCCCCCCCCCCCCCC	41.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGKQ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EHD1_HUMAN	EHD1	physical	22939629
KAT1_HUMAN	CCBL1	physical	22939629
EHD4_HUMAN	EHD4	physical	22939629
EZRI_HUMAN	EZR	physical	22939629
IF4H_HUMAN	EIF4H	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.