NUP40_SCHPO - dbPTM
NUP40_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUP40_SCHPO
UniProt AC O13838
Protein Name Nucleoporin nup40
Gene Name nup40
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 371
Subcellular Localization Nucleus, nuclear pore complex. Nucleus membrane
Peripheral membrane protein
Cytoplasmic side. Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side. Biased towards cytoplasmic side.
Protein Description Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm)..
Protein Sequence MSFGGSGSITNRSTLKPLSVDDLRSPSPQKEYRGFRTSVSNIPQEKKFVPSHLSHFGSSQQRRFAPEVSSPLAEPYESSSSFRLSLSSPPSSKFGGPSFGTPKPFLHTNRLGTGSLIEDAPPTQSIYDFSSSRQINALNVGQSSSPFSPVSEKVYDPSFTMSGAPQDSNTSVIVFGFPPELTNQVIAEFSRFGTIISENSLTASSAGFTPSKGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSPAEAKEHVPKTLRNSNKDLEMTDASSSETSMSIPVHADAHFQSQSGLGKKVIVQHKNDIFKSSQKHQPRNWLFHYLFGFGSTEPIDEEEKSKTASDNTSLQTSLFGKIVQVVLHTLFGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFGGSGSI
------CCCCCCCCC		32.3829996109
11N-linked_GlycosylationGGSGSITNRSTLKPL
CCCCCCCCCCCCCCC		33.95-
13PhosphorylationSGSITNRSTLKPLSV
CCCCCCCCCCCCCCH		39.9129996109
14PhosphorylationGSITNRSTLKPLSVD
CCCCCCCCCCCCCHH		35.2529996109
19PhosphorylationRSTLKPLSVDDLRSP
CCCCCCCCHHHCCCC		31.8421712547
25PhosphorylationLSVDDLRSPSPQKEY
CCHHHCCCCCCCHHH		36.7124763107
27PhosphorylationVDDLRSPSPQKEYRG
HHHCCCCCCCHHHCC		41.0125720772
38PhosphorylationEYRGFRTSVSNIPQE
HHCCCCCCCCCCCHH		21.2029996109
59PhosphorylationHLSHFGSSQQRRFAP
HHHHCCCHHHHCCCC		30.6129996109
69PhosphorylationRRFAPEVSSPLAEPY
HCCCCCCCCCCCCCC		25.2829996109
70PhosphorylationRFAPEVSSPLAEPYE
CCCCCCCCCCCCCCC		29.1625720772
87PhosphorylationSSFRLSLSSPPSSKF
CCEEEEECCCCHHHC		37.1129996109
88PhosphorylationSFRLSLSSPPSSKFG
CEEEEECCCCHHHCC		46.2328889911
91PhosphorylationLSLSSPPSSKFGGPS
EEECCCCHHHCCCCC		49.9329996109
92PhosphorylationSLSSPPSSKFGGPSF
EECCCCHHHCCCCCC		37.4628889911
101PhosphorylationFGGPSFGTPKPFLHT
CCCCCCCCCCCCCCC		26.5724763107
130PhosphorylationTQSIYDFSSSRQINA
CCCCEECCCCCCEEE		25.2229996109
148PhosphorylationGQSSSPFSPVSEKVY
CCCCCCCCCCCCCCC		27.9829996109
169N-linked_GlycosylationSGAPQDSNTSVIVFG
CCCCCCCCCEEEEEC		44.66-
242N-linked_GlycosylationLSNGMLINDSFMVGC
HHCCCEECCCEEEEE		34.61-
315PhosphorylationKNDIFKSSQKHQPRN
HHHHHHHCCCCCCCH		43.7824763107
349N-linked_GlycosylationKSKTASDNTSLQTSL
HHCCCCCCCHHHHHH		29.13-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUP40_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUP40_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUP40_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCS7_SCHPOscs7genetic
18818364
SWD1_SCHPOswd1genetic
18818364
FFT3_SCHPOfft3genetic
18818364
ELP3_SCHPOelp3genetic
18818364
POM1_SCHPOpom1genetic
18818364
DYL1_SCHPOdlc2genetic
18818364
TRM61_SCHPOcpd1genetic
18818364
EME1_SCHPOeme1genetic
18818364
SLX9_SCHPOslx9genetic
18818364
AMO1_SCHPOamo1genetic
18818364
COPE_SCHPOsec28genetic
18818364
ASK1_SCHPOask1genetic
18818364
HIR1_SCHPOhip1genetic
18818364
ELP6_SCHPOelp6genetic
18818364
HPC2_SCHPOhip4genetic
18818364
ELP4_SCHPOelp4genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
MU154_SCHPOmug154genetic
18818364
ALP14_SCHPOalp14genetic
18818364
ABP1_SCHPOcbp1genetic
18818364
MUG66_SCHPOatg101genetic
22681890
VHT1_SCHPOvht1genetic
22681890
NSE6_SCHPOnse6genetic
22681890
HS104_SCHPOhsp104genetic
22681890
PT191_SCHPOSPBC16A3.16genetic
22681890
VID27_SCHPOSPBC1685.14cgenetic
22681890
YNVB_SCHPOSPBC3H7.11genetic
22681890
BQT3_SCHPObqt3genetic
22681890
NU132_SCHPOnup132genetic
22681890
GLO22_SCHPOSPCC13B11.03cgenetic
22681890
TR852_SCHPOtrs8502genetic
22681890
SWR1_SCHPOswr1genetic
22681890
MUG61_SCHPOman1genetic
22681890
RAD13_SCHPOrad13genetic
22681890
ILVB_SCHPOilv1genetic
22681890
BQT4_SCHPObqt4genetic
22681890
ELP6_SCHPOelp6genetic
22681890
LYS1_SCHPOlys3genetic
22681890
YD53_SCHPOSPAC6C3.03cgenetic
22681890
NUP60_SCHPOnup60genetic
22681890
EFTS_SCHPOtsf1genetic
22681890
YFT2_SCHPOSPAC926.02genetic
22681890
MEX67_SCHPOmex67genetic
22681890
ATG18_SCHPOatg1801genetic
22681890
DEP1_SCHPOdep1genetic
22681890
SIF2_SCHPOsif2genetic
22681890
EXO5_SCHPOexo5genetic
22681890
NEM1_SCHPOnem1genetic
22681890
GET1_SCHPOget1genetic
22681890
MBO1_SCHPOmto1genetic
22681890
ARZ1_SCHPOarz1genetic
22681890
IST1_SCHPOist1genetic
22681890
MET10_SCHPOSPCC584.01cgenetic
22681890
SWD1_SCHPOswd1genetic
22681890
OBP1_SCHPOSPBC646.08cgenetic
22681890
PO152_SCHPOpom152genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
POM1_SCHPOpom1genetic
22681890
YKX4_SCHPOSPAC328.04genetic
22681890
WIS4_SCHPOwis4genetic
22681890
PYRE_SCHPOura5genetic
22681890
PPR8_SCHPOppr8genetic
22681890
YJ48_SCHPOSPCC70.08cgenetic
22681890
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
ASH2_SCHPOash2genetic
22681890
YGB8_SCHPOSPBC25B2.08genetic
22681890
PSL1_SCHPOpsl1genetic
22681890
SGO1_SCHPOsgo1genetic
22681890
SET11_SCHPOset11genetic
22681890
CTL1_SCHPOctl1genetic
22681890
APQ12_SCHPOapq12genetic
22681890
ATG16_SCHPOatg16genetic
22681890
MTNB_SCHPOSPAC20H4.05cgenetic
22681890
YH05_SCHPOSPBC1685.05genetic
22681890
YHP4_SCHPOrmn1genetic
22681890
YHE7_SCHPOSPBPB2B2.07cgenetic
22681890
YO88_SCHPOSPBC21D10.08cgenetic
22681890
OMH1_SCHPOomh1genetic
22681890
PMP31_SCHPOpmp31genetic
22681890
CTK3_SCHPOlsg1genetic
22681890
PIT1_SCHPOpit1genetic
22681890
PPK16_SCHPOppk16genetic
22681890
NMT1_SCHPOnmt1genetic
22681890
TRM82_SCHPOSPCC18.13genetic
22681890
RGA5_SCHPOrga5genetic
22681890
YGNJ_SCHPOalb1genetic
22681890
SUM2_SCHPOsum2genetic
22681890
DAD2_SCHPOdad2genetic
22681890
CTA5_SCHPOcta5genetic
22681890
YNV5_SCHPOSPBC3H7.05cgenetic
22681890
YCPE_SCHPOtrp663genetic
22681890
YA99_SCHPOSPAC13G6.09genetic
22681890
CTU2_SCHPOctu2genetic
22681890
MU154_SCHPOmug154genetic
22681890
RL9A_SCHPOrpl901genetic
22681890
MOK11_SCHPOmok11genetic
22681890
KLP6_SCHPOklp6genetic
22681890
CTU1_SCHPOctu1genetic
22681890
BGLS_SCHPOSPBC1683.04genetic
22681890
NAA38_SCHPOnaa38genetic
22681890
SEC74_SCHPOsec74genetic
22681890
UPF3_SCHPOupf3genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUP40_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-92, AND MASSSPECTROMETRY.

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