dbPTM

LEG9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LEG9_HUMAN
UniProt AC	O00182
Protein Name	Galectin-9
Gene Name	LGALS9
Organism	Homo sapiens (Human).
Sequence Length	355
Subcellular Localization	Cytoplasm . Nucleus . Secreted . May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). Isoform 2: Secreted . Isoform 3: Secreted .
Protein Description	Binds galactosides. [PubMed: 18005988 Has high affinity for the Forssman pentasaccharide]
Protein Sequence	MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGDIQLTHVQT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	PRFEDGGYVVCNTRQ CCCCCCCEEEEECCC	8.67	17360941
88	Ubiquitination	SWGPEERKTHMPFQK CCCHHHHCCCCCCCC	46.17	-
152	Phosphorylation	ISFQNPRTVPVQPAF EEECCCCEECCCCCC	30.34	-
173	Methylation	QPVCFPPRPRGRRQK CCCCCCCCCCCCCCC	33.51	-
227	Ubiquitination	HPAYPMPFITTILGG CCCCCCCCHHHHHCC	6.70	-
240	Phosphorylation	GGLYPSKSILLSGTV CCCCCCCEEEEECCC	23.86	26552605
244	Phosphorylation	PSKSILLSGTVLPSA CCCEEEEECCCCCCC	29.04	26552605
246	Phosphorylation	KSILLSGTVLPSAQR CEEEEECCCCCCCCE	18.59	26552605
250	Phosphorylation	LSGTVLPSAQRFHIN EECCCCCCCCEEEEE	32.64	26552605
286	Phosphorylation	RNTQIDNSWGSEERS ECCEECCCCCCCCCC	29.12	30108239
289	Phosphorylation	QIDNSWGSEERSLPR EECCCCCCCCCCCCC	29.99	28857561
293	Phosphorylation	SWGSEERSLPRKMPF CCCCCCCCCCCCCCC	46.11	30108239
297	Ubiquitination	EERSLPRKMPFVRGQ CCCCCCCCCCCCCCC	49.32	-
305	Phosphorylation	MPFVRGQSFSVWILC CCCCCCCCEEEEEEE	23.47	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LEG9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LEG9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LEG9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	17353931
PLAK_HUMAN	JUP	physical	17353931
AAAT_HUMAN	SLC1A5	physical	17353931
PTPRK_HUMAN	PTPRK	physical	26186194
RNF13_HUMAN	RNF13	physical	26186194
K319L_HUMAN	KIAA0319L	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
MET_HUMAN	MET	physical	26186194
S12A2_HUMAN	SLC12A2	physical	26186194
RRAGC_HUMAN	RRAGC	physical	26186194
MFAP3_HUMAN	MFAP3	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
NID2_HUMAN	NID2	physical	26186194
CD166_HUMAN	ALCAM	physical	26186194
CD109_HUMAN	CD109	physical	26186194
FPRP_HUMAN	PTGFRN	physical	26186194
NR3L1_HUMAN	NCR3LG1	physical	26186194
SORL_HUMAN	SORL1	physical	26186194
PODXL_HUMAN	PODXL	physical	26186194
LAMB1_HUMAN	LAMB1	physical	26186194
PTPRJ_HUMAN	PTPRJ	physical	26186194
FINC_HUMAN	FN1	physical	26186194
ZER1_HUMAN	ZER1	physical	26186194
LFA3_HUMAN	CD58	physical	26186194
S12A4_HUMAN	SLC12A4	physical	26186194
S12A6_HUMAN	SLC12A6	physical	26186194
LAMA4_HUMAN	LAMA4	physical	26186194
S29A1_HUMAN	SLC29A1	physical	26186194
AT11C_HUMAN	ATP11C	physical	26186194
ANAG_HUMAN	NAGLU	physical	26186194
LAMA1_HUMAN	LAMA1	physical	26186194
LCAP_HUMAN	LNPEP	physical	26186194
MA2B1_HUMAN	MAN2B1	physical	26186194
PLXA1_HUMAN	PLXNA1	physical	26186194
DAG1_HUMAN	DAG1	physical	26186194
S4A7_HUMAN	SLC4A7	physical	26186194
MRC2_HUMAN	MRC2	physical	26186194
ITA4_HUMAN	ITGA4	physical	26186194
SL9A6_HUMAN	SLC9A6	physical	26186194
SC6A6_HUMAN	SLC6A6	physical	26186194
S12A7_HUMAN	SLC12A7	physical	26186194
ENPP4_HUMAN	ENPP4	physical	26186194
AT133_HUMAN	ATP13A3	physical	26186194
CD47_HUMAN	CD47	physical	26186194
ATP7A_HUMAN	ATP7A	physical	26186194
PTN11_HUMAN	PTPN11	physical	26186194
LEG3_HUMAN	LGALS3	physical	26186194
RRAGB_HUMAN	RRAGB	physical	26186194
FBLN1_HUMAN	FBLN1	physical	26186194
ITB1_HUMAN	ITGB1	physical	26186194
S38A9_HUMAN	SLC38A9	physical	26186194
IGSF3_HUMAN	IGSF3	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
MPZL1_HUMAN	MPZL1	physical	26186194
LEG9B_HUMAN	LGALS9B	physical	26186194
OSTM1_HUMAN	OSTM1	physical	26186194
LUM_HUMAN	LUM	physical	26186194
CLCN3_HUMAN	CLCN3	physical	26186194
CD63_HUMAN	CD63	physical	26186194
PCDH9_HUMAN	PCDH9	physical	26186194
K1549_HUMAN	KIAA1549	physical	26186194
ATG9A_HUMAN	ATG9A	physical	26186194
CSPG4_HUMAN	CSPG4	physical	26186194
S12A9_HUMAN	SLC12A9	physical	26186194
SUSD5_HUMAN	SUSD5	physical	26186194
NHRF2_HUMAN	SLC9A3R2	physical	26186194
PDIA1_HUMAN	P4HB	physical	21670307
PDIA3_HUMAN	PDIA3	physical	21670307
PDIA6_HUMAN	PDIA6	physical	21670307
DAG1_HUMAN	DAG1	physical	28514442
PTPRJ_HUMAN	PTPRJ	physical	28514442
LAMA1_HUMAN	LAMA1	physical	28514442
LAMA4_HUMAN	LAMA4	physical	28514442
CSPG4_HUMAN	CSPG4	physical	28514442
NID2_HUMAN	NID2	physical	28514442
CLCN3_HUMAN	CLCN3	physical	28514442
K1549_HUMAN	KIAA1549	physical	28514442
OSTM1_HUMAN	OSTM1	physical	28514442
PODXL_HUMAN	PODXL	physical	28514442
IGSF3_HUMAN	IGSF3	physical	28514442
FINC_HUMAN	FN1	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
S4A7_HUMAN	SLC4A7	physical	28514442
SL9A6_HUMAN	SLC9A6	physical	28514442
MET_HUMAN	MET	physical	28514442
S12A6_HUMAN	SLC12A6	physical	28514442
ATG9A_HUMAN	ATG9A	physical	28514442
NHRF2_HUMAN	SLC9A3R2	physical	28514442
CD166_HUMAN	ALCAM	physical	28514442
ENPP4_HUMAN	ENPP4	physical	28514442
PTPRK_HUMAN	PTPRK	physical	28514442
S12A7_HUMAN	SLC12A7	physical	28514442
LEG9B_HUMAN	LGALS9B	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
CD109_HUMAN	CD109	physical	28514442
RRAGC_HUMAN	RRAGC	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
MRC2_HUMAN	MRC2	physical	28514442
RRAGB_HUMAN	RRAGB	physical	28514442
ITA4_HUMAN	ITGA4	physical	28514442
S38A9_HUMAN	SLC38A9	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
SC6A6_HUMAN	SLC6A6	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
CD63_HUMAN	CD63	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
CD47_HUMAN	CD47	physical	28514442
ECE1_HUMAN	ECE1	physical	28514442
LAMB1_HUMAN	LAMB1	physical	28514442
S12A2_HUMAN	SLC12A2	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
SORL_HUMAN	SORL1	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
ANAG_HUMAN	NAGLU	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
LFA3_HUMAN	CD58	physical	28514442
PLXA1_HUMAN	PLXNA1	physical	28514442
FPRP_HUMAN	PTGFRN	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
ZER1_HUMAN	ZER1	physical	28514442
MA2B1_HUMAN	MAN2B1	physical	28514442
NID1_HUMAN	NID1	physical	28514442
ITB1_HUMAN	ITGB1	physical	28514442
CD276_HUMAN	CD276	physical	28514442
LRP1_HUMAN	LRP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LEG9_HUMAN

Related Literatures of Post-Translational Modification