dbPTM

JUNB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	JUNB_MOUSE
UniProt AC	P09450
Protein Name	Transcription factor jun-B
Gene Name	Junb
Organism	Mus musculus (Mouse).
Sequence Length	344
Subcellular Localization	Nucleus.
Protein Description	Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'..
Protein Sequence	MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLADPYRGLKGPGARGPGPEGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGTGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASGGPQAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPPFAGGHPAQLGLSRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSAAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	AAAGYGRSPGSLSLH CCCCCCCCCCCCCHH	29.29	28725479
26	Phosphorylation	GYGRSPGSLSLHDYK CCCCCCCCCCHHHHH	20.40	28725479
28	Phosphorylation	GRSPGSLSLHDYKLL CCCCCCCCHHHHHCC	25.92	28725479
36	Acetylation	LHDYKLLKPTLALNL HHHHHCCCCEEEHHC	46.52	23806337
100	Phosphorylation	PNSNGVITTTPTPPG CCCCCCEECCCCCCC	23.39	27087446
101	Phosphorylation	NSNGVITTTPTPPGQ CCCCCEECCCCCCCC	21.47	22942356
102	Phosphorylation	SNGVITTTPTPPGQY CCCCEECCCCCCCCC	19.26	27087446
104	Phosphorylation	GVITTTPTPPGQYFY CCEECCCCCCCCCCC	39.77	27087446
117	Phosphorylation	FYPRGGGSGGGTGGG CCCCCCCCCCCCCCC	37.22	25266776
121	Phosphorylation	GGGSGGGTGGGVTEE CCCCCCCCCCCCCHH	35.61	28066266
126	Phosphorylation	GGTGGGVTEEQEGFA CCCCCCCCHHHHCCC	36.76	25777480
234	Phosphorylation	LGLSRGASAFKEEPQ HCCCCCCHHCCCCCC	36.74	25266776
237	Sumoylation	SRGASAFKEEPQTVP CCCCHHCCCCCCCCC	61.97	-
237	Sumoylation	SRGASAFKEEPQTVP CCCCHHCCCCCCCCC	61.97	-
237	Acetylation	SRGASAFKEEPQTVP CCCCHHCCCCCCCCC	61.97	23806337
242	Phosphorylation	AFKEEPQTVPEARSR HCCCCCCCCCCHHHC	49.06	27149854
248	Phosphorylation	QTVPEARSRDATPPV CCCCCHHHCCCCCCC	41.37	27087446
252	Phosphorylation	EARSRDATPPVSPIN CHHHCCCCCCCCCCC	32.20	27087446
256	Phosphorylation	RDATPPVSPINMEDQ CCCCCCCCCCCHHHH	26.32	27087446
267	Sumoylation	MEDQERIKVERKRLR HHHHHHHHHHHHHHH	44.24	-
267	Sumoylation	MEDQERIKVERKRLR HHHHHHHHHHHHHHH	44.24	-
299	Phosphorylation	RLEDKVKTLKAENAG HHHHHHHHHHHHHCC	36.16	22817900
301	Sumoylation	EDKVKTLKAENAGLS HHHHHHHHHHHCCHH	59.91	-
301	Sumoylation	EDKVKTLKAENAGLS HHHHHHHHHHHCCHH	59.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
256	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
256	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Wwp1	Q8BZZ3	PMID:21809421

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of JUNB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of JUNB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BATF_MOUSE	Batf	physical	20211142
BATF3_MOUSE	Batf3	physical	20211142
DSRAD_HUMAN	ADAR	physical	26496610
BIRC2_HUMAN	BIRC2	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
CCNT1_HUMAN	CCNT1	physical	26496610
CIRBP_HUMAN	CIRBP	physical	26496610
SYEP_HUMAN	EPRS	physical	26496610
BPTF_HUMAN	BPTF	physical	26496610
FOSL2_HUMAN	FOSL2	physical	26496610
MTOR_HUMAN	MTOR	physical	26496610
T2FB_HUMAN	GTF2F2	physical	26496610
ROA1_HUMAN	HNRNPA1	physical	26496610
ROA2_HUMAN	HNRNPA2B1	physical	26496610
IMDH1_HUMAN	IMPDH1	physical	26496610
IMDH2_HUMAN	IMPDH2	physical	26496610
TNPO1_HUMAN	TNPO1	physical	26496610
LCAP_HUMAN	LNPEP	physical	26496610
MFAP1_HUMAN	MFAP1	physical	26496610
DPOLB_HUMAN	POLB	physical	26496610
RPN2_HUMAN	RPN2	physical	26496610
SDCB1_HUMAN	SDCBP	physical	26496610
RU2A_HUMAN	SNRPA1	physical	26496610
SPG7_HUMAN	SPG7	physical	26496610
SRPRA_HUMAN	SRPR	physical	26496610
RO52_HUMAN	TRIM21	physical	26496610
SPT5H_HUMAN	SUPT5H	physical	26496610
BACD2_HUMAN	TNFAIP1	physical	26496610
XRCC1_HUMAN	XRCC1	physical	26496610
SF01_HUMAN	SF1	physical	26496610
ZSC21_HUMAN	ZSCAN21	physical	26496610
AIMP2_HUMAN	AIMP2	physical	26496610
BRD3_HUMAN	BRD3	physical	26496610
IFT88_HUMAN	IFT88	physical	26496610
RBM10_HUMAN	RBM10	physical	26496610
EIF3B_HUMAN	EIF3B	physical	26496610
MED14_HUMAN	MED14	physical	26496610
TRIP4_HUMAN	TRIP4	physical	26496610
DDX23_HUMAN	DDX23	physical	26496610
MED17_HUMAN	MED17	physical	26496610
MCA3_HUMAN	EEF1E1	physical	26496610
JADE3_HUMAN	JADE3	physical	26496610
MED24_HUMAN	MED24	physical	26496610
ZC11A_HUMAN	ZC3H11A	physical	26496610
MED12_HUMAN	MED12	physical	26496610
MED16_HUMAN	MED16	physical	26496610
TSSC4_HUMAN	TSSC4	physical	26496610
RBM6_HUMAN	RBM6	physical	26496610
RBM5_HUMAN	RBM5	physical	26496610
SF3A1_HUMAN	SF3A1	physical	26496610
HNRPQ_HUMAN	SYNCRIP	physical	26496610
CHERP_HUMAN	CHERP	physical	26496610
KIF1C_HUMAN	KIF1C	physical	26496610
AFG32_HUMAN	AFG3L2	physical	26496610
ROA0_HUMAN	HNRNPA0	physical	26496610
CKAP4_HUMAN	CKAP4	physical	26496610
SF3B2_HUMAN	SF3B2	physical	26496610
KAT7_HUMAN	KAT7	physical	26496610
ECD_HUMAN	ECD	physical	26496610
DNJC8_HUMAN	DNAJC8	physical	26496610
SCAF8_HUMAN	SCAF8	physical	26496610
SR140_HUMAN	U2SURP	physical	26496610
SF3B1_HUMAN	SF3B1	physical	26496610
BRD4_HUMAN	BRD4	physical	26496610
NNTM_HUMAN	NNT	physical	26496610
TNPO3_HUMAN	TNPO3	physical	26496610
FKBP8_HUMAN	FKBP8	physical	26496610
OSBL3_HUMAN	OSBPL3	physical	26496610
GOLI4_HUMAN	GOLIM4	physical	26496610
HTSF1_HUMAN	HTATSF1	physical	26496610
RMD1_HUMAN	RMDN1	physical	26496610
PCF11_HUMAN	PCF11	physical	26496610
MED15_HUMAN	MED15	physical	26496610
UIMC1_HUMAN	UIMC1	physical	26496610
WDR74_HUMAN	WDR74	physical	26496610
GTPB2_HUMAN	GTPBP2	physical	26496610
P66A_HUMAN	GATAD2A	physical	26496610
OXSM_HUMAN	OXSM	physical	26496610
MED9_HUMAN	MED9	physical	26496610
AGGF1_HUMAN	AGGF1	physical	26496610
PNPO_HUMAN	PNPO	physical	26496610
MED29_HUMAN	MED29	physical	26496610
DEP1A_HUMAN	DEPDC1	physical	26496610
CCAR1_HUMAN	CCAR1	physical	26496610
PCNP_HUMAN	PCNP	physical	26496610
K1143_HUMAN	KIAA1143	physical	26496610
CAMP3_HUMAN	CAMSAP3	physical	26496610
SQOR_HUMAN	SQRDL	physical	26496610
TTC31_HUMAN	TTC31	physical	26496610
CS043_HUMAN	C19orf43	physical	26496610
MEP50_HUMAN	WDR77	physical	26496610
MRM1_HUMAN	MRM1	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
NSRP1_HUMAN	NSRP1	physical	26496610
HDGR2_HUMAN	HDGFRP2	physical	26496610
PRC2B_HUMAN	PRRC2B	physical	26496610
SPF45_HUMAN	RBM17	physical	26496610
PPIL4_HUMAN	PPIL4	physical	26496610
BAP18_HUMAN	C17orf49	physical	26496610
RBM33_HUMAN	RBM33	physical	26496610
ADCK5_HUMAN	ADCK5	physical	26496610
RGPD3_HUMAN	RGPD3	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of JUNB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248; THR-252 ANDSER-256, AND MASS SPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, AND MASSSPECTROMETRY.	17242355 [Abstract]