dbPTM

UBE2U_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBE2U_HUMAN
UniProt AC	Q5VVX9
Protein Name	Ubiquitin-conjugating enzyme E2 U
Gene Name	UBE2U
Organism	Homo sapiens (Human).
Sequence Length	321
Subcellular Localization
Protein Description	Catalyzes the covalent attachment of ubiquitin to other proteins..
Protein Sequence	MHGRAYLLLHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTNYTLSSILLALQVMLSNPVLENPVNLEAARILVKDESLYRTILRLFNRPLQMKDDSQELPKDPRKCIRPIKTTSFSDYYQTWSRIATSKATEYYRTPLLKVPNFIGQYYKWKKMDLQHQKEWNLKYSVIKCWLARKRMPHEVTHSMEEIKLCPTLIPTTDEIFLESPTAINSITDIYETEEEGWKSDTSLYENDTDEPREEEVEDLISWTNTLNTNTSED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Phosphorylation	KCIRPIKTTSFSDYY HCCCCCCCCCHHHHH	28.52	-
182	Phosphorylation	SFSDYYQTWSRIATS CHHHHHHHHHHHHCC	14.86	-
197	Phosphorylation	KATEYYRTPLLKVPN CCCEEECCCCCCCCC	11.36	24719451
227	Phosphorylation	QKEWNLKYSVIKCWL HHHHHHHHHHHHHHH	16.01	30631047
228	Phosphorylation	KEWNLKYSVIKCWLA HHHHHHHHHHHHHHH	18.77	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBE2U_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBE2U_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBE2U_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC11_HUMAN	ANAPC11	physical	19690564
BARD1_HUMAN	BARD1	physical	19690564
BFAR_HUMAN	BFAR	physical	19690564
MUL1_HUMAN	MUL1	physical	19690564
CAPS2_HUMAN	CADPS2	physical	19690564
CGRF1_HUMAN	CGRRF1	physical	19690564
DTX1_HUMAN	DTX1	physical	19690564
R144B_HUMAN	RNF144B	physical	19690564
RNFT1_HUMAN	RNFT1	physical	19690564
RN181_HUMAN	RNF181	physical	19690564
MDM2_HUMAN	MDM2	physical	19690564
MIB1_HUMAN	MIB1	physical	19690564
MIB2_HUMAN	MIB2	physical	19690564
TRIM1_HUMAN	MID2	physical	19690564
KAT6A_HUMAN	KAT6A	physical	19690564
RNF41_HUMAN	RNF41	physical	19690564
PCGF1_HUMAN	PCGF1	physical	19690564
PCGF2_HUMAN	PCGF2	physical	19690564
PJA1_HUMAN	PJA1	physical	19690564
PML_HUMAN	PML	physical	19690564
RNF11_HUMAN	RNF11	physical	19690564
R113A_HUMAN	RNF113A	physical	19690564
R113B_HUMAN	RNF113B	physical	19690564
RNF14_HUMAN	RNF14	physical	19690564
RN150_HUMAN	RNF150	physical	19690564
RN166_HUMAN	RNF166	physical	19690564
RNF17_HUMAN	RNF17	physical	19690564
RN170_HUMAN	RNF170	physical	19690564
RING2_HUMAN	RNF2	physical	19690564
RNF25_HUMAN	RNF25	physical	19690564
RNF26_HUMAN	RNF26	physical	19690564
RNF5_HUMAN	RNF5	physical	19690564
SYVN1_HUMAN	SYVN1	physical	19690564
TRAIP_HUMAN	TRAIP	physical	19690564
RN139_HUMAN	RNF139	physical	19690564
TRIM2_HUMAN	TRIM2	physical	19690564
TIF1A_HUMAN	TRIM24	physical	19690564
TIF1B_HUMAN	TRIM28	physical	19690564
TRIM3_HUMAN	TRIM3	physical	19690564
TRI34_HUMAN	TRIM34	physical	19690564
TRI35_HUMAN	TRIM35	physical	19690564
TRI37_HUMAN	TRIM37	physical	19690564
TRI38_HUMAN	TRIM38	physical	19690564
TRI47_HUMAN	TRIM47	physical	19690564
TRI54_HUMAN	TRIM54	physical	19690564
TRI63_HUMAN	TRIM63	physical	19690564
TRI65_HUMAN	TRIM65	physical	19690564
TRI68_HUMAN	TRIM68	physical	19690564
VPS41_HUMAN	VPS41	physical	19690564
RN114_HUMAN	RNF114	physical	19690564
ZSWM2_HUMAN	ZSWIM2	physical	19690564
TRI23_HUMAN	TRIM23	physical	19549727
TRI74_HUMAN	TRIM74	physical	19549727
HOIL1_HUMAN	RBCK1	physical	19549727
VPS11_HUMAN	VPS11	physical	19549727
RN125_HUMAN	RNF125	physical	19549727
DZIP3_HUMAN	DZIP3	physical	19549727
R144B_HUMAN	RNF144B	physical	19549727
MKRN3_HUMAN	MKRN3	physical	19549727
PCGF6_HUMAN	PCGF6	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RNF10_HUMAN	RNF10	physical	19549727
TRI15_HUMAN	TRIM15	physical	19549727
TRI32_HUMAN	TRIM32	physical	19549727
TRI46_HUMAN	TRIM46	physical	19549727
TRIM5_HUMAN	TRIM5	physical	19549727
VPS28_HUMAN	VPS28	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	21516116
MB12A_HUMAN	MVB12A	physical	28514442
VPS28_HUMAN	VPS28	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBE2U_HUMAN

Related Literatures of Post-Translational Modification