ZSWM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZSWM2_HUMAN
• UniProt AC: Q8NEG5
• Protein Name: E3 ubiquitin-protein ligase ZSWIM2
• Gene Name: ZSWIM2
• Organism: Homo sapiens (Human).
• Sequence Length: 633
• Protein Description: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes..
• Protein Sequence: MLRRGYKASERRRHLSERLSWHQDQALSSSIYLLREMGPTGFLLREEEPEYMDFRVFLGNPHVCNCSTFPKGGELCKHICWVLLKKFKLPRNHESALQLGLGEREISDLLRGIHRVQTPQPGTNDENEHVEEDGYIKQKEIDSEDICSICQELLLEKKLPVTFCRFGCGNSIHIKCMKILANYQSTSNTSMLKCPLCRKEFAPLKLILEEFKNSSKLVAAAEKERLDKHLGIPCNNCKQFPIEGKCYKCTECIEYHLCQECFDSCCHLSHTFTFREKRNQKWRSLEKRADEVVKYIDTKNEIEEKMSHFQEKQGQVYTPKHIVRSLPLQLITKNSKLLAPGYQCLLCLKAFHLGQHTRLLPCTHKFHRKCIDNWLFHKCNSCPIDGQVIYNPLTWKNSAVNGQAHQSVSNRDIIHLSKQKEPDLFIPGTGLVLKQNRLGILPSIPQCNFDELNTPQSPKDAYENTTIDNLCSIKLDNSNSKKLTYDYKISQHFPRYLQDLPTVSFGKIPSQTLLPPIVHKNIVCPTAMESPCISGKFHTSLSRMTKGCKCNNHNLKKTPATKIREDNKRSTLLPEDFNLIVNWSTAKLSLSKRYSNCMGEITRKCSHLSRQPVSHSVNTKSTELSLIIEGVQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
273	Phosphorylation	CHLSHTFTFREKRNQ HHHHCCEEHHHHHHH	23.96	-
317	Phosphorylation	QEKQGQVYTPKHIVR HHHCCCCCCHHHHHH	14.94	22798277
318	Phosphorylation	EKQGQVYTPKHIVRS HHCCCCCCHHHHHHH	27.31	22798277
496	Phosphorylation	ISQHFPRYLQDLPTV HHHHCHHHHCCCCCC	14.67	29759185
542	Phosphorylation	GKFHTSLSRMTKGCK CCCCHHHHHHCCCCC	21.55	-
545	Phosphorylation	HTSLSRMTKGCKCNN CHHHHHHCCCCCCCC	24.15	-
589	Phosphorylation	NWSTAKLSLSKRYSN CCHHHHHHHHHHHHC	29.86	24719451
594	Phosphorylation	KLSLSKRYSNCMGEI HHHHHHHHHCHHHHH	14.15	24505115
595	Phosphorylation	LSLSKRYSNCMGEIT HHHHHHHHCHHHHHH	27.82	24505115
602	Phosphorylation	SNCMGEITRKCSHLS HCHHHHHHHHCHHHH	21.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ZSWIM2	Q8NEG5	PMID:16522193

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZSWM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZSWM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCAM_HUMAN	BCAM	physical	28514442
TKTL2_HUMAN	TKTL2	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442
LRFN4_HUMAN	LRFN4	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.